1. Methyl Hesperidin Overview
Methyl Hesperidin is a dihydroflavonoids compound. It is obtained by methylation using hesperidin as raw material that is extracted from fruits such as orange and tangerine. Methyl Hesperidin can maintain the normal permeability of blood vessels, and enhance the capillary resistance. It alleviates skin-redness. It also has the biological activity of inhibiting tyrosinase and scavenging hydroxyl radical. Moreover, Methyl Hesperidin has a strong absorbency for 265-295nm UV rays. Accordingly, Methyl Hesperidin, as a natural cosmetic raw material, can be applied in skin-whitening, anti-aging and removing skin-redness products. It has a great development prospect in cosmetic industry.
| Product Name | CAS Number | INCI Name | |
| Methyl Hesperidin | 11013-97-1 | Methyl Hesperidin | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| 624.59g/mol | C29H36O15 |  |
|
| Product ID | Specificcation | Minimal Package | Minimal Order Quantity |
| PMM0101 | 94% | 1KG | 1KG |
2. Methyl Hesperidin Botanical Source
Citrus sinensis is a citrus plant in rutaceae family. It is planted all over the south of Qinling mountains in China. It is mainly distributed in Jiangsu, Zhejiang, Hubei, Hunan, Jiangxi, Fujian, Taiwan, Guangdong, Guangxi, Sichuan, Guizhou and Yunnan provinces. It is also distributed from southwest of China to the southeastern part of Tibet about below 1,500 meters above sea level. It is usually cultivated in hills and low mountains, or along rivers and lakes. The fruit of citrus sinensis is round, oblate or elliptic. Its color is orange yellow to orange red. It has many effects such as alleviating hangover, relieving cough. Hesperidin present in fresh orange fruit can reduce capillary brittleness, and prevent micro-vascular hemorrhage. The fruit is rich in vitamin C, P and organic acids. It has obvious regulation and inhibition effect for human body metabolism. It can enhance the body resistance. Therefore, extracts of citrus sinensis has a broad development prospect in the pharmaceutical industry.
3. Methyl Hesperidin Manufacturer Specifications
| Product Name | Specification |
| Methyl Hesperidin | 94% UV |
| Items | Specifications |
| Assay | ≥94%UV |
| Organoleptic | |
| Appearance | Orange yellow Powder |
| Odor | Characteristic |
| Taste | Characteristic |
| Identifications | |
| 10 mg + 10 ml of 60% ethanol + Mg | A violet red color develops |
| 10 mg + 10 ml of 60% ethanol + Fe Cl | A brown red color develops |
| Tests | |
| Chalcone（TLC） | Conforms |
| Physical Characteristics | |
| Particle Size | 98% through 80 mesh |
| Loss on Drying | ≤5% |
| Residue on ignition | ≤0.5% |
| Heavy Metals | |
| Total Heavy Metals | ≤20ppm |
| As | ≤2ppm |
| Pb | ≤2ppm |
| Microbiological Tests | |
| Total Plate Count | ≤1000cfu/g |
| Total Yeast & Mold | ≤100cfu/g |
| E.Coli. | Negative |
4. Methyl Hesperidin Manufacturer Flow Chart
5. Methyl Hesperidin Benefits
- whitening skin and anti-oxidation
Methyl Hesperidin has effect of inhibiting tyrosinase and preventing melanin formation. So it can remove freckles and dark spots on the skin; and it can whiten skin. Methyl Hesperidin has the ability of scavenging hydroxyl free radical. Its combination with zinc, calcium and other complexes can improve the ability of scavenging free radical. It can exert anti-oxidation and sun protection effect.
- Anti-allergic and anti-bacterial
Methyl Hesperidin has the same effect as vitamin P. It can enhance the effect of vitamin C. It has stronger antivirus and antibacterial effect. Thus it can be used to repair allergic skin, and eliminate skin inflammation.
- Strengthening capillary resistance
Methyl Hesperidin can maintain normal vascular permeability; it can improve capillary resistance, and enhance the elasticity and toughness of capillary. Thereby it prevents and treats capillary hemorrhage and gingival hemorrhage. Also it can relieve facial skin-redness. It can promote the circulation of the scalp capillaries. Its combination with vitamin C derivatives can improve the blood flow of the scalp capillaries, which is beneficial to hair growth. Therefore, it can be used in removing skin-redness products, hair care and teeth care products.
6. Pharmacological studies of Methyl Hesperidin and cosmetics
| Test Item | Concentration | Result |
| Elimination of hydroxyl radicals | 25ug/mL | Elimination rate: 25.7% |
| Promotion of the metabolism rate of cuticle | 1.0% | Promotion rate: 7.9% (Compare to Blank) |
| Promotion of water content in the cuticle applied to skin | 2.0% | Promotion rate: 160 (blank 100) |
| Promotion of hair growth in mice | 0.5% | Promotion rate: 119.4 % |
7. Plamed Methyl Hesperidin Characteristic
- Good solubility; easy to be added into cosmetics.
8. Methyl Hesperidin Application
Plamed Methyl Hesperidin is mainly used in cosmetics and personal care products.
| Application products | Function |
| Whitening cream | Remove black spots and freckles; prevent and repair skin-redness; whiten skin. |
| Shampoo | Combination with vitamin C can improve the blood flow of capillaries in the scalp; helpful for hair growth. |
| Toothpaste | Adding 0.1% Methyl Hesperidin to toothpaste can inhibit the formation of dental plaque, eliminate halitosis, and prevent bleeding gums. |
| Nail polish | Prevent fingernail from being yellow; improve brittle and soft nails. |
| Frostbite cream | Prevent and repair skin frostbite. |
9. Methyl Hesperidin Reference Formula
Anti-freeze and anti-crack hand cream:
| Ingredient | Content(%) | Ingredient | Content(%) | |
| Phase A | Hexadecyl glycosides | 1~2 | Isopropyl myristate | 1.5 |
| Spermaceti Ammonium stearyl sulfate | 0.2~0.3 | Oligosaccharides | 1 | |
| Shea butter | 4~5 | Jojoba oil | 3 | |
| Caprylic triglyceride | 3~6 | Polydimethylsiloxane | 3~8 | |
| Lecithin | 0.2~0.6 | |||
| Phase B | Vitamin B3 | 1~2.5 | Mycose | 4~5 |
| Modified corn starch | 2~3 | Glycerin | 3~5 | |
| Allantoin | 0.2~0.45 | Carbomer | 0.2~0.3 | |
| Methylparaben | 0.2 | Deionized water | 55.95 | |
| Phase C | Triethanolamine | 0.2 | β-glucan | 0.55~1 |
| Methyl Hesperidin | 3~6 | Phenoxyethanol | 0.5 | |
| Fragrance | 0.15~0.2 | |||
Preparation method：
Heat phase A ingredients and phase B ingredients to 78~80℃ respectively, then add phase A to phase B. And homogenize for 2 minutes, stir and cool to 60℃, then add Triethanolamine. Cool and stir to 48℃, then addβ-glucan, Methyl Hesperidin, Phenoxyethanol and Fragrance. Stir and cool to 32℃, then get the cream.
10. Methyl Hesperidin Safety
- Cosmetic, Toiletry &Fragrance Association (CTFA) has approved Methyl Hesperidin as a cosmetic ingredient.
- Methyl Hesperidin is listed in The List of Used Cosmetic Ingredient approved by the Ministry of Health of the People’s Republic of China in 2001.
- Methyl Hesperidin is included in The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI. No reports show its insecurity.
11. Packing and Storage
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional Methyl Hesperidin manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Methyl Hesperidin and good Methyl Hesperidin price will help customers make good terminal products and help customers win a lasting and broad market.
