Paeoniflorin Manufacturer

1. Paeoniflorin Overview

2. Paeoniflorin Source

White peony (Latin name: Cynanchum otophyllum) is a plant of Paeonia genus in Paeoniaceae family. It is native to central and eastern Asia; and now it grows in temperate regions all over the world. It also is a Chinese herbal plant. It is distributed in mountainous areas, valley woodlands or hillsides at an altitude of 1500-2800 meters. In China, it is mainly distributed in Zhejiang, Anhui, Guizhou, Yunnan, Sichuan and Tibet provinces. Its main active ingredients are monoterpenoids, phenols, tannins, sterols, flavonoids, volatile oils, amino acids, proteins and other compounds. Paeoniflorin is a principal active ingredient in dried roots of Paeoniae; it has many biological activities such as anti-inflammatory and anti-oxidation. Therefore, it is widely used in cosmetics and pharmaceutical industries.

3. Paeoniflorin Manufacturer Specifications

Product Name	Specification
Paeoniflorin	70%, 98%

Paeoniflorin 70% Specifications

Items	Specification
Assay	≥70.00%
Appearance	Off-white fine powder
Odor	Characteristic
Taste	Characteristic
Used part	Root
Physical Characteristics
Particle size	98%through 80 mesh
Loss on drying	≤5.00%
Ash content	≤5.00%
Density	0.40-0.70g/ml
Heavy Metals
Heavy metals	≤10ppm
As	≤2ppm
Pb	≤2ppm
Hg	≤1ppm
Microbiological Tests
Total Plate count	≤1000cfu/g
Yeast & mold	≤100cfu/g
Escherichia coli	Negative
Staphylococcus	Negative
Salmonella	Negative

Paeoniflorin 98% Specifications

Items	Specification
Paeoniflorin	≥98%
Test method	HPLC
Appearance	White or off-white powder
Odor	Characteristic
Physical Characteristics
Boiling point	684_9℃ at 760mmHg
Partical Size	98% through 80 Mesh
MoistureContent	≤1%
Total Ash Content	≤0.1%
Solvent residue	≤3000PPM
Heavy Metals
Heavy metals	≤10ppm
As	≤2ppm
Pb	≤2ppm
Microbiological Tests
Total Plate count	≤1000cfu/g
Yeast & mold	≤100cfu/g
Escherichia coli	Negative
Staphylococcus	Negative
Salmonella	Negative

4. Paeoniflorin Manufacturer Flow Chart

5. Paeoniflorin Benefits

• Anti-inflammation

Paeoniflorin exerts an anti-inflammatory effect by inhibiting production of TNF-α and IL-1β and promoting expression of IL-10. The study result indicates that Paeoniflorin antagonizes chemokine formation induced by TNF-α and leukocyte migration. Therefore, Paeoniflorin shows a broad spectrum of anti-inflammatory property.

• Anti-wrinkle & anti-aging

Paeoniflorin can enhance vitality and performance of skin cells. It promotes collagen fibers’ synthesis. Thereby Paeoniflorin contributes to increasing of toughness and elasticity of skin tissue; also it reduces production of lipid peroxides. Accordingly, Paeoniflorin significantly prevents intrinsic skin aging as well as DNA damage and skin wrinkling caused by UV. And compared with vitamin E, Paeoniflorin can better increase cell growth rate. Therefore, cosmetics containing Paeoniflorin are very effective anti-aging products.

Cell	Treatment (M)	Cell growth rate	Cell mortality rate	Cell aging rate
keratinocytes	Blank	–	–	–
	Paeoniflorin 0.0005M	55.3%	12.3%	24.7%
	Vitamin E 0.0004M	23.3%	10.5%	20.1%
Fibroblast	Blank	–	–	–
	Paeoniflorin 0.0005M	18.4%	11.5%	17.2%
	Vitamin E 0.0004M	9.96%	15.4%	22.8%

6. Study on the Pharmacology of Paeoniflorin Cosmetics

Test item	Concentration	Result
Elimination to hydroxyl radicals	60.3μg/mL	Elimination rate：46.7%
Inhibition to cell apoptosis induced by hydrogen peroxide	10μmol/L	Inhibition rate：40%
Inhibition to IL-2 production	2.5g/kg	Inhibition rate：34.4%
Inhibition to IL-6 production	2.5g/kg	Inhibition rate：24.8%
Inhibition to IL-10 production	2.5g/kg	Inhibition rate：80.2%
Inhibition to MMP-9 activity	0.01mmol/L	Inhibition rate：30.0%
Inhibition to NF-kB cell activity	100μg/mL	Inhibition rate：53.2%

7. Plamed Paeoniflorin Characteristic

• Plamed owns white peony planting bases. We can provide Paeoniflorin stably.

8. Paeoniflorin Application & Dosage

Paeoniflorin is applied in cosmetics for treatment of acne and anti-inflammation including serum, cleanser, cream, emulsion, toner and so on.

Application product	Recommended Dosage
Anti-wrinkle and anti-inflammation skin care products	0.001-10%

Paeoniflorin application cases in major cosmetic brands in the world

Country	Brand	Product
Japan	IPSA	The Time Reset Aqua
	Dr. Ci: Labo	Aqua-Collagen-Gel Super Sensitive O2 Herbal Gel Oxygen Charge
	Cle De Peau Beaute	The Serum Refreshing Cleansing Foam l
Korea	SULWHASOO	Overnight Vitalizing Mask Essential Balancing Water Ex First Care Activating Serum Ex Evenfair Perfrcting Cushion No.1 Clarifying Mask
	Whoo	Bichup Ja Saeng Essence Cheongidan Hwa Hyun Lotion
	AHC	Hydra B5 Lotion Premium Hydra B5 Sleeping Pack
	ReEn	Yungo the First Cleansing Treatment
	ACWELL	Aqua Clinity Cream
China	Herborist	Whitening & Revitalizing Mask Whitening Toner T’ai Chi Detoxifying & Nutrient Clay
	Inoherb	Rhodiola Fine Whitening & Anti-Oxidation Cleansing Foam
	You Yan	Balance Toner
	Carslan	BB Cushion

9. Paeoniflorin Reference Formula

Skin-care cream

Phase	Ingredient	Content (%)	Ingredient	Content (%)
A	Paeoniflorin	4	Pearl hydrolysate	10
	Grape seed oil	1.5	β-glucan	8
	Bee pollen	0.2	Leucine	2
	Lysine	2	Aloe extract	8
B	Span-60	2	Tween-60	1
	Imidazolidinyl urea	0.1
C	Refined cottonseed oil	7
D	Fragrance	0.4
E	Octadecanol	2	Sorbitol Solution(70)	3
	Deionized water	Add to 100

Cleanser

Phase	Ingredient	Content (%)	Ingredient	Content (%)
A	Paeoniflorin	6	Aloe extract	10
	Pearl hydrolysate	11	Grape seed oil	2
	Β-glucan	10	Bee pollen	1
	Leucine	2	Lysine	2
B	Octadecanol	2	Squalane	3
	Self-emulsifying monoglycerin stearate	1
C	C9-10 Decyl glucoside	20	Deionized water	Add to 100

Skin-care lotion

Phase	Ingredient	Content (%)	Ingredient	Content (%)
A	Paeoniflorin	5	Aloe extract	10
	Pearl hydrolysate	12	Grape seed oil	2
	Β-glucan	8	Bee pollen	0.2
	Leucine	2	Lysine	2
	Citric acid	1
B	Fragrance	0.2	Cetanol	3
C	Lanolin	4	Glycerin monostearate	3
	Glycerin	2.5	Isopropyl myristate	2
	Triethanolamine	1	Stearic acid	2
	Methylparaben	0.2	Deionized water	Add to 100

Toner

Phase	Ingredient	Content (%)	Ingredient	Content (%)
A	Paeoniflorin	5	Aloe extract	12
	Pearl hydrolysate	12	Grape seed oil	2
	Β-glucan	5	Bee pollen	0.2
	Leucine	1	Lysine	1
	Citric acid	1
B	Stearic acid	3	Emulsifier	3
	Deionized water	Add to 100

Cream

Ingredient	Content (%)	Ingredient	Content (%)
Paeoniflorin	0.5	Stearic acid	1.0
Cetanol	2.0	PEG-20	1.0
Sorbitan monostearate	1.0	Mineral oil	10.0
Tricaprylin	5.0	Triethanolamine	0.5
Carbomer	0.2	Glycerin	5.0
Propylene glycol	3.0	Preservative	Appropriate
Fragrance	Appropriate	Purified water	Add to 100

Essence

Ingredient	Content (%)	Ingredient	Content (%)
Paeoniflorin	1	Propylene glycol	10.0
Glycerin	10.0	Sodium hyaluronate solution (1%)	5.0
Ethanol	5.0	Castor oil	1.0
Methyl 4-hydroxybenzoate	0.1		0.3
Triethanolamine	0.4	Fragrance	Appropriate
Purified water	Add to 100

10. Paeoniflorin Safety

• Paeoniflorin is listed on The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI.
• Paeoniflorin has been considered as cosmetic raw material by Cosmetic, Toiletry & Fragrance Association (CTFA).

11. Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Paeoniflorin manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Paeoniflorin and good Paeoniflorin price will help customers make good terminal products and help customers win a lasting and broad market.