1. PMSoothe® 9728 Overview
PMSoothe® 9728 is a newly developed natural cosmetic ingredient with strong analgesic and instant anti-irritant effects. It is extracted from the dried rhizome of kava pepper by alcohol and water. The very sensitive skin is is caused by an overreaction of sensory nerves. PMSoothe® 9728 can effectively suppress the excessive reaction of sensory nerves, thereby significantly improving the skin’s tolerance to external stimulation. PMSoothe® 9728 would be widely used in products for sensitive skin or products with certain irritant.
| Product Name | CAS No. | INCI Name | |
| PMSoothe® 9728 | 84696-40-2 | PIPER METHYSTICUM ROOT EXTRACT | |
| Product ID | Specification | Minimal Package | Minimal Order Quality |
| PMS0101 | PMS0101 | 1KG | 1KG |
2. Irritation Instant Relieving Material PMSoothe® 9728 Botanical Source
Kava pepper (Piper methysticum Forst) is a perennial upright shrub of the pepper family, produced in the South Pacific islands, wild or cultivated, roots and rhizomes can be used as medicine, the effective part is the fat-soluble resin part. The main active ingredients of kava pepper are kavalactone and kavain. Because of its sedative, local anesthetic and antibacterial properties, kava pepper has long been a widely used medicinal ingredient in European and American countries and regions, and is also widely used as a food supplement. The dried rhizomes are mainly used in cosmetic raw materials.
3. Irritation Instant Relieving Material PMSoothe® 9728 Manufacturer Specification
| Items | Specification |
| Part used | Root |
| Organoleptic Tests | |
| Appearance | Off white to white powder |
| Odor | Characteristic |
| Taste | Characteristic |
| Physical Characteristics | |
| Moisture | ≤10.0% |
| Ash content | ≤7.0% |
| Heavy Metals | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microbiological Tests | |
| Total of bacteria | ≤1000cfu/g |
| Yeast & mold | ≤100cfu/g |
| Pseudomonas aeruginosa | Not detected |
| Staphylococcus aureus | Not detected |
| E. coli | Not detected |
4. PMSoothe® 9728 Mechanism of Irritation Relieving
PMSoothe® 9728 can inhibit the expression of TRPV1 and the transmission of action potentials, meaning it can inhibit both the reception and conduction of stimuli, so as to quickly sooth skin.
- PMSoothe®9728 at 0.781mg/mL could significantly inhibit the expression of TRPV1 in skin induced by external
- PMSoothe®9728 at 10mg/mL could significantly reduce the release frequency of neuronal cell action potentials by 97.58%.
- Please scan the QR code below to watch the vedio how PMSoothe® 9728 soothes sensitive skin.
5. Irritation Instant Relieving Material PMSoothe® 9728 Benefits
- Anti-irritant and analgesia
PMSoothe® 9728 is able to reduce effectively the irritation felt by skin neuron cells, instantly relieve skin allergic reactions, stinging, burning, itching, redness, etc.
Zebrafish analgesic efficacy test find that 0.67% PMSoothe® 9728 has significant anti-irritant effect.
- Soothing
PMSoothe® 9728 has the effect of relieving fatigue and stress, soothing emotions, and relaxing facial skin.
- Anti-inflammation
In vitro culture studies have shown that by inhibiting the production of inflammatory mediator (exogenous prostaglandin PGE2), PMSoothe® 9728 has anti-inflammatory effects on cells.
6. Plamed PMSoothe® 9728 Characteristic
- Easy to use
PMSoothe® 9728 is 100% water-soluble, and the water solution is clear and transparent, no precipitation.
- Strong and instant anti-irritant effect
PMSoothe® 9728 can instantly reduce the damage of external stimulation to the skin.
Please scan the QR code below to watch the skin anti-irritant test vedio.
7. PMSoothe® 9728 Application & Reference Dosage
| Application Product | Reference Dosage |
| Facial cleanser, toner, essence, lotion, cream, gel, eye cream, aftershave, etc. | 0.3-3.0% |
Formulation suggestions:
- PMSoothe® 9728 needs to be dissolved inabove 80℃ hot water, the maximum solubility is 10%.
- PMSoothe® 9728 is complementary to the anti-allergy mechanism conventional inflammatory inhibitors, and it can be used in conjunction with the conventional inflammatory inhibitors.
8. Irritation Instant Relieving Material PMSoothe® 9728 Safety
- Kava extract is CFDA (China Food and Drug Administration) has approved the use of cosmetic ingredients.
- International Cosmetic Raw Material Standard Chinese Name Directory (2015 edition) has included kava extract.
- PMSoothe®9728 doesn’t show any cytotoxicity at the concentration of 0.6%
- PMSoothe® 9728 has no irritation at the concentration of 1% in vitro eye irritation test
9. PMSoothe® 9728 Customer Feedback
10. Irritation Instant Relieving Material PMSoothe® 9728 Reference Formula
Lotion
| Ingredient | Content (%) | Ingredient | Content (%) | |
| Phase A | Ethylhexyl methoxycinnamate | 2.0 | C12-15 benzoate | 3.0 |
| Cetyl alcohol | 1.0 |
|
||
| Phase B | Deionized water | Add to 100 | Polyol | 5.0 |
| Emulsifier | 1.0 | Thickener | 0.2 | |
| Phase C | PMSoothe® 9728 | 0.5 | Argania spinosa leaf extract | 1.0 |
| Lactobacillus fermentation lysate | 0.5 | Garcinia mangostana bark extract | 0.1 | |
| Lilium candidum bulb extract | 0.1 | Musa sapientum fruit extract | 1.0 | |
| Preservative | 0.8 | Fragrance | 0.1 | |
Preparation:
- Put phase A to oil pot, heat to 70-85 ℃, stir to dissolve completely.
- Put phase B to emulsifying pot, heat to 70-85 ℃, stir and dissolve completely.
- Put phase A into the emulsifying pot to emulsify homogeneously together with phase B, then keep the temperature.
- Stir to cool to 30-40 ℃, add the components of phase C to the emulsifying pot, stir evenly, then inspect.
Acne Essence
| Ingredient | Content (%) | Ingredient | Content (%) |
| PMSoothe® 9728 | 0.5 | Portulaca oleracea extract | 0.5 |
| Polygonum cuspidatum extract | 0.1 | Scutellaria baicalensis extract | 0.1 |
| Green tea extract | 1.0 | Glycyrrhiza glabra extract | 0.2 |
| Chamomilla recutita flower extract | 0.1 | Rosemary extract | 1.0 |
| Dipotassium glycyrrhizinate | 2.0 | Hydroxyphenyl propamidobenzoic acid | 0.1 |
| 10- hydroxydecanoic acid | 1.6 | Glycerol | 8.0 |
| Butanediol | 4.0 | Small molecule hyaluronic acid | 1.5 |
| Deionized water | Add to 100 | ||
11. Packing and Storage
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
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Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional irritation instant relieving material PMSoothe® 9728 manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good PMSoothe® 9728 and good irritation instant relieving material PMSoothe® 9728 price will help customers make good terminal products and help customers win a lasting and broad market.
