DCR 516-A Natural Cosmetic Ingredient for Relieving Skin Allergy

In the South Pacific, kava kava is a plant that has been used for more than 3,000 years. Local people regarded it as the “sacred medicine”, and the local residents praised it as the “highest-status plant”. Plamed uses modern extraction technology to extract the active ingredient from kava and named it DCR516. After testing, it is proven that DCR516 is a best natural cosmetic ingredient for relieving skin allergy.

Mechanism of DCR516 Cosmetic Ingredient for Relieving Skin Allergy 

Plamed’s test found that DCR516 external use has a fast and powerful soothing effect, which can significantly improve skin tolerance and resist external stimuli. A joint study by the University of Sydney and the University of Copenhagen found that DCR 516’s active component Kavain acts on GABA receptors. Through the regulation of neurotransmitters to obtain a powerful soothing function, this is exactly the difference between DCR516 and other anti-allergic ingredients on the market. DCR516’s mechanism for relieving skin allergy is to inhibit the production and release of inflammatory factors.

(A) Representative traces demonstrating kavain (10–300 μM) enhancing current elicited by 10 μM GABA (EC3) at α1β2γ2L GABAARs in a concentration-dependent manner.

(B) Representative traces of current responses elicited by a maximal concentration of GABA (10 mM), in comparison to 300 μM kavain alone.

Benefits of Cosmetic Ingredient DCR516 for Relieving Skin Allergy

• Cosmetic Ingredient DCR516 for Analgesic and Anti-irritant

DCR516 can effectively reduce the irritation received by skin neuron cells, thereby instantly relieving skin’s irritation, burning, itching, redness and swelling caused by external stimuli.

Zebrafish test the anti-allergy ability of DCR516, and found that DCR516 had a very significant anti-stimulation ability when the dosage is 0.06%.

• Cosmetic Ingredient DCR516 Soothing Skin

DCR516 has the properties to relieve skin stress and fatigue. So it can be used in night skincare products, including sleeping pack, night cream, etc.

• Cosmetic Ingredient DCR516 for Anti-inflammation

In vitro studies demonstrated that DCR516 has anti-inflammatory effects on cells. Because it inhibits the production of inflammatory mediators (exogenous prostaglandin PGE2).

Tests of Cosmetic Ingredient DCR516 for Relieving Skin Allergy

Plamed invites subjects to use 0.05% capsaicin solution to stimulate the skin of the forearm, and then use 3% DCR516 aqueous solution for soothing. The test found that the forearm that did not use DCR516 had obvious tingling, burning, redness and swelling. DCR516 can greatly relieve the irritation caused by capsaicin and relieve skin redness and swelling.

Fudan University mentioned in the article Advances in Chemical Components and Pharmacological Studies on Kava Piper methysticum that the analgesic effect of Kava is better than that of aspirin.

Figure. DCR516 relieving skin allergy, compared with aspirin

Plamed also tests DCR516 by stimulating zebrafish with glacial acetic acid; as a result, DCR516 has a significant topical analgesic effect.

Figure. Zebrafish behavior trajectory after DCR516 treatment

A cosmetics engineer in Nigeria added 1% DCR516 to 2% salicylic acid serum, and 21 subjects used it. They all reported that the skin did not feel any irritation.

Plamed’s customer from China compounded 0.5% DCR516 in a phenoxyethanol-containing mask. DCR516 can significantly reduce skin’s burning sensation caused by phenoxyethanol.

Uses of Cosmetic Ingredient DCR516 for Relieving Skin Allergy

• DCR516 is water-soluble; it needs to be soluble in water above 80℃.
• 1g DCR516 can be dissolved in 10ml water.
• In the cosmetic formulas, DCR516 can be compatible with other anti-inflammation agent.
• DCR516 can combine with salicylic acid, in order to relieve skin irritation of salicylic acid.
• Through the skin test, it is concluded that the amount of DCR516 added within 3% is directly proportional to the skin allergy relieving effect.

In conclusion, DCR516 is an effective cosmetic ingredient for relieving skin allergy. It can be applied in skincare products for sensitive skin. Plamed has proven its anti-allergy effect by many tests, such as zebrafish test, eye irritation test, cytotoxicity test and others. You can click the following blogs for more information on DCR516 for relieving skin allergy.