1. Ectoin Overview
Ectoin is derived from microbial extracts under high temperature, high salt, and high ultraviolet environments. It is a cyclic amino acid derivative. Studies have shown that Ectoine has the effects of delaying skin aging, preventing ultraviolet rays, anti-oxidation, and moisturizing.
Ectoin can maintain the balance of osmotic pressure inside and outside the cell and prevent cell dehydration. Ectoin is the most widely distributed compatible substance found in the bacterial kingdom. It is compatible with intracellular metabolism, and does not affect the cell’s biological macromolecular functions or physiological processes. Ectoine also has other important functions. Because of the dense charge of molecular surface, it is easy to bind water molecules to achieve moisturizing effect. Moreover, Ectoin can protect and repair skin.
Product Name | CAS Number | INCI Name | |
Ectoin | 96702-03-3 | ECTOIN | |
Molecular Weight | Molecular Formula | Molecular Structure | |
142.2g/mol | C6H10O2N2 | ||
Product ID | Specification | Minimal Package | Minimal Order Quantity |
PMS1201 | 98% | 1KG | 1KG |
2. Ectoin Source
In 1985, the German scientist Professor Galinski discovered halophilic bacteria in Egyptian desert. Halophilic bacteria will produce a natural protective ingredient in the outer layer of cells under high temperature, dryness, strong UV irradiation, and high salinity. The ingredient is Ectoin. have found There is this kind of “salt-tolerant” bacteria, halophilic bacteria in many high-salt lakes and saline-alkali lands, such as the Chaka Salt Lake and Chaerhan Salt Lake in China. They are also excellent for producing Ectoin. Nowadays, Ectoin is made by biochemical method.
3. Ectoin Manufacturer Specifications
Product Name | Specification | Color |
Ectoin | 98% | White powder |
Items | Specifications |
Assay | ≥98% |
Appearance | White powder |
pH | 5.0-7.0 |
Physical Characteristics | |
Loss on drying | ≤0.5% |
Specific rotation | +139~+145 (C=1, CH3OH) |
Heavy Metals | |
Pb | ≤0.9mg/kg |
As | ≤0.5mg/kg |
Microbiological Tests | |
Total Plate count | ≤1000cfu/g |
Yeast & mold | ≤50cfu/g |
Escherichia coli | ≤10cfu/g |
Staphylococcus | ≤100cfu/g |
Salmonella | Negative |
4. Ectoin Benefits
- Moisturizing
The cyclic structure of ectoin molecules has strong electronegativity. Thus, it is easy to form hydrogen bonds with water molecules, and enhances the associative ability of water molecules. Also,
Ectoin can penetrate deep into the epidermis, which is different from the short-term nature and dependence of other moisturizing agents. It can truly repair skin’s water-locking system, and compensate for the rapid loss of water after low-molecular-weight hyaluronic acid is injected.
- Repair Skin
When skin cells are exposed to environmental pressures, such as high temperature, ultraviolet radiation, hypoxia, heavy metals, viral infections, etc., Ectoin will produce emergency protection and regeneration reactions, and generate heat shock proteins to help each skin cell maintain normal physiological activities. In addition, Ectoin can be used to calm and soothe irritated and damaged skin, and significantly improve the regeneration process of the skin.
Data show that 4.0% ectoine can reduce skin cells sunburn caused by ultraviolet radiation by 80% to 90%.
- Anti-inflammation
Ectoin is a powerful ordering substance that can form a barrier around cells, enzymes, proteins and other biological molecules. Due to the existence of the barrier, the skin cells are equivalent to being “armed”, blocking or reducing the stimulation of the skin cells by external stimulating factors, thereby alleviating skin inflammation.
5. Pharmacological Studies of Ectoin in Relation to Cosmetics
Test Items | Concentration | Result |
Promotion of relative activity of superoxide dismutase | 0.7mol/L | Relative enzyme activity increased by 25.7% |
Coating promotes the increase of water content in the stratum corneum of the skin | 1.0% | Promotion rate: >10% |
Inhibition of Melanocyte Apoptosis under UVA (365nm, 0.8J/cm2) | 2mmol/L | Inhibition rate: 68.1% |
Inhibition of apoptosis of keratinocytes under UVB (100mJ/cm2) | 4.0% | Inhibition rate: 88.9% |
Inhibition of apoptosis of neutrophils by cell culture | 1mmol/L | Inhibition rate: 54.2% |
Inhibition of the activity of B-16 melanocytes | 0.1mmol/L | Inhibition rate: 38.7% |
6. Plamed Ectoin Characteristic
- Ectoinhas a good water-solubility, and it is easy to be added in cosmetic
- The extraction process is safe and effective, without residual pollutants.
7. Ectoin Application and Reference Dosage
Ectoin is mainly used in whitening skin care products, such as serum, facial mask, emulsion, toner, essence, cream, etc.
Product | Reference Dosage |
Ectoin | 0.3-2.0% |
Ectoin application cases in major cosmetic brands in the world
Country | Brand | Product |
China | Dr. Alva | Probiotics Professional Deep Repair Mask |
Umoua | Barrier Repair Essence Advanced | |
Camellia | Soothing Facial Toner
Soothing Lotion |
|
Proya | Elastic Brightening Youth Essence | |
Winona | Double Repair Ageless Essence | |
USA | Mentholatum | Skin Aqua UV Super Moisture Gel |
Japan | Shiseido | Gentle Sun Protection Lotion
Ultimune Power Infusing Eye Concentrate |
Cle de peau | Beaute Intensive Fortifying Emulsion | |
New Zealand | Geoskincare | Renew Miracle Skin Protector B.B Cream |
Korea | Histoire Naturelle | Hydra Sooth Mild Serum |
8.Ectoin Reference Formula
Skin Spray
Ingredient | Content (%) | Ingredient | Content (%) |
Ectoin | 2.5 | Sodium Hyaluronate | 0.3 |
Butanediol | 5.0 | Dermatan Sulfate Sodium Salt | 5.0 |
Glycerin | 3.0 | Propylene Glycol | 3.0 |
Betaine | 2.0 | Allantoin | 0.1 |
Water | Add to 100 |
Night Skincare Product
Ingredient | Content (%) | Ingredient | Content (%) |
Ectoin | 1.0 | Glycerin | 2.0 |
Magnesium Sulfate | 1.2 | Caprylic/Capric/Linoleic Triglyceride | 5.0 |
Decyl Cocoate | 8.0 | Polyglyceryl-3 Diisostearate | 2.0 |
Cera Alba | 0.5 | Polyglyceryl-3 Polyricinoleate | 3.0 |
Water | Add to 100 | Isocetyl Stearoyl Stearate | 2.0 |
Fragrance | Q.s. | Ganoderma Atrum (Mushroom) Extract | 1.0 |
Preservative | Q.s. |
9. Ectoin Safety
- CTFAhas recognized ECTOIN as a raw material for cosmetics;
- The International Catalogue of Chinese Cosmetic Raw Materials Standardsin 2010 issued by ECTOIN.
- On the Announcement of Name List of Cosmetics Raw Materialpublished by CFDA in 2021 both include ECTOIN. There are no reports indicating that ECTOIN is unsafe for external use.
10. Package and Storage
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional Ectoin manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Ectoin and good Ectoin price will help customers make good terminal products and help customers win a lasting and broad market.