Nicotinamide & Niacinamide manufacturer

1. Nicotinamide & Niacinamide & Vitamin b3 Overview

Nicotinamide & Niacinamide is a vitamin B form. It can be also called Vitamin B₃. It is a significant niacin derivative, mainly occurring in many organisms. Nicotinamide & Niacinamide can produce coenzyme Ⅰ and Ⅱ when it reacts with ribose, adenine and phosphoric acid. Also it boosts the synthesis of DNA, fats and proteins and improves the energy metabolism of cells. So it can greatly prevent melanin deposition, and reduce discoloration. It has an effective whitening function. Nowadays, as a natural cosmetics ingredient, it is widely applied in skin and hair care products. Plamed Nicotinamide is divided into  medical grade and  cosmetics grade.

Product Name	CAS Number	INCI Name
Nicotinamide	98-92-0	NIACINAMIDE
Molecular Weight	Molecular Formula	Molecular Structure
C6H6N2 O	112.1g/mol
Product ID	Specificcation	Minimal Package	Minimal Order Quantity
PMB1801	99%	1KG	1KG

2. Nicotinamide & Niacinamide Preparation Method

Nicotinamide is obtained by synthesis. There are 2 methods: biosynthesis and chemical. Plamed produces Nicotinamide by the biological method, because of its non-pollution, low consumption and suitability for mass production. All of these advantages can benefit customers a lot.

3. Nicotinamide & Niacinamide & Vitamin b3 Manufacturer Specifications

4. Nicotinamide & Niacinamide & Vitamin b3 Manufacturer Process Flow Chart

5. Niacinamide Benefits

• Prevent melanin from depositing into keratinocytes

Skin will darken when melanin is delivered to keratinocytes. But Nicotinamide can act on generated melanin, and then efficiently prevent the transfer of 35% to 40% of melanin from melanocytes to horny cells. Hence, it can lessen excessive pigmentation. Clinical tests have suggested that Nicotinamide face cream can obviously reduce the brown spots ‘ number and area.

• Accelerate the metabolism of melanocytes

Nicotinamide is directly absorbed by cells owing to its small molecules. Nicotinamide can penetrate the inner layer of the skin within 2 hours. Using Nicotinamide to the skin can form energy molecules in human body quickly. It can penetrate the stratum corneum to the connective tissue and fibers between the dermis; and then it directly gets in the bottom of the cell to facilitate the metabolism of cells.

• Promote synthesis of cortical proteins on skin

Nicotinamide synthesizes protein on the surface of skin. And it amends skin texture, and moisturizes skin. In 1990, European Patent 0-396-422 shows that it can whiten skin and exert sun block effect to add Nicotinamide, 0.1% to 5% silicone compound and UVA, UVB sunscreen into the cream formulation.

6. Application and Reference Dosage of Niacinamide

Nicotinamide is applied in skin-care products, such as whitening cream, spot removing essence, moisturizing lotion, etc. Also it can be added into shampoo, hair conditioner to stop hair loss and relieve itch. Usually it can be mingled with  glycerol, retinol to make cosmetics.

Attention：

• When pH value of Nicotinamide is less than 5, it will be disintegrated to niacin. Niacin is harmful for skin. Therefore, Nicotinamide’s pH value should be controlled in range of 5~7.
• Nicotinamide can hardly absorbed by skin when above 5% concentration’s. Below 5% dosage will be beneficial to skin. Thus the dosage of Nicotinamide should be controlled.
• Avoid to use Niacinamide with salicylic acid, alpha hydroxy acid and other acids. Because under acidic conditions, Niacinamide will be decomposed into niacin, causing irritation.

Nicotinamide’s application cases in cosmetics around the world:

7. Niacinamide Reference Formula

Whitening toner：

Shampoo：

8. Nicotinamide Safety

• Both European Union (EU) and Cosmetic, Toiletry and Fragrance Association(CTFA) have recognized Nicotinamide as cosmetics ingredient.
• CAFFCI’s 2010 edition-The Catalog Of the International Cosmetics Raw Material Standard English Name and On the Announcement of Name List of Cosmetics Raw Material published by China Food and Drug Administration(CFDA) in 2014 also specify Nicotinamide as cosmetics component.

9. Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and heat.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Nicotinamide manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Nicotinamide and good Nicotinamide price will help customers make good terminal products and help customers win a lasting and broad market.