Osthole manufacturer

1. Osthole Overview

Osthole is also known as Cnidium Monnieri Fruit Extract. It is a cosmetic plant material extracted from the dried fruits of Cnidium. Osthole is the main active ingredient of Cnidium. Tests have shown that Osthole can inhibit the activity of trichophyton mentagrophytes and molds. It can treat skin eczema and other facial diseases. The moisture absorption test of Osthole indicates that it has great hygroscopicity and moisturizing function. So, Osthole can be used for skin care products to prevent dry skin. Osthole can keep the skin clean and has a good skin-care effect. Osthole has antibacterial and anti-inflammatory effect, so it can be used in feminine care products. Thus, its application in the cosmetic field is hugely prospective. Plamed Osthole is white fine powder of 98% specification, and belongs to cosmetic grade.

2. Osthole Source

Cnidium monnieri, also called Cnidii Fructus, is the dry ripe fruit of plant Cnidium. The fruit is obovate; its fruiting season is from August to November. It mainly grows in hillsides, grasslands, roadsides, shrubs and understory forests at an altitude of 1300-3200 meters. It is distributed in most areas in China; the major Cnidium growth areas are Sichuan, Hebei, Shandong, Anhui, Jiangsu, Zhejiang, etc. Also, it can be found in foreign countries, such as Russia, North Korea, Vietnam, North America. Cnidium contains many effective ingredients, including bergapten, imperatorin, osthole, as well as volatile oils, such as pinene and cinene. Cnidium can enhance immunity, and have bactericidal and insecticidal effect. It is widely used in the pharmaceutical and personal care products.

3. Osthole Manufacturer Specifications

Osthole HPLC Chromatogram

4. Osthole Manufacturer Process Flow Chart

5. Osthole Benefits

• Removing tinea and relieving itching

Osthole’s anti-pruritic mechanism is related to the stabilization of mast cell membrane and inhibition of histamine release from skin’s mast cells. It has obvious antipruritic effect. Experiment shows that the active component R2 of Osthole can significantly increase the itch threshold of histamine phosphate to guinea pigs. Also it can greatly inhibit pruritus reaction induced by 4-aminopyridine; and it prevents histamine release from mast cells in skin tissue. It can effectively treat mice auricle swelling induced by xylene. Osthole combining with other coumarins can block the signal transduction pathway caused by substance P, and replaces the itch consciousness to achieve antipruritic effect.

• Anti-inflammation

In vitro experiment on mice shows that Osthole can inhibit the ear swelling caused by xylene; and it can suppress the increase of capillary permeability in abdominal cavity caused by acetic acid. It obviously inhibit the granuloma in mice. Osthole inhibits calcium influx in cells, and increases the level of cyclic GMP. Then it can affect the activity of nitric oxide synthase, and the content of PG, NO, and MDA to exert anti-inflammation effect. In addition, it has been reported that Osthole influences central nervous system by inhibiting peripheral inflammatory substances to achieve anti-inflammatory function.

• Anti-bacterial

Osthole has an anti-bacterial effect on mycoplasma urealytium in vitro. Its minimum inhibitory concentration (MIC) is 62.5~125 μg/mL. Osthole can significantly reduce the pathogenicity of staphylococcus aureus remnants.

6. Plamed Osthole Characteristic

• Plamed owns Cnidium planting base, which can ensure high-quality of raw material and stable supply for customers.
• Plamed has developed Osthole for 10 years with price advantage.
• First extract fructus cnidii oil, then extract Osthole. So Plamed Osthole has a cost advantage.

7. Osthole Application & Reference Dosage

• As a traditional Chinese medicine, Cnidium has been used to treat skin eczema and other diseases, which is related to the inhibition of ringworm and mold by Osthole. So Osthole can be used in the skin care products for removing eczema.
• Osthole has a broad antibacterial spectrum. It can be used in acne treatment and anti-inflammation skin care products.
• Osthole has antibacterial and anti-inflammatory effect. It can be used in feminine care products.

8. Osthole Reference Formula

Fragrant cream：

9. Osthole Safety

• Osthole is included in The List of Used Cosmetic Ingredient approved by the Ministry of Health of the People’s Republic of China in 2001.
• There is no report showing that Osthole is unsafe for external use.

10. Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and heat.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Osthole manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Osthole and good Osthole price will help customers make good terminal products and help customers win a lasting and broad market.