1. PMWhite® Glabridin300 Overview
Glabridin is a kind of flavonoids, extracted from the dry rhizomes of Glycyrrhiza glabra. It is known as “whitening gold” because of its powerful whitening effect. Glabridin can effectively inhibit tyrosinase activity, thereby inhibiting the production of melanin. It is a safe, mild as well as effective whitening active ingredient. Experimental data show that the whitening effect of Glabridin is 232 times that of vitamin C, 16 times that of hydroquinone, and 1164 times that of arbutin.
As the top three whitening ingredients and ranked 11th in the popularity of functional ingredients, Glabridin has always been favored by consumers. Data show that the popularity of Glabridin is increasing year by year. As a popular and effective raw material, its value is discounted because of its high cost.
As a result, Plamed develops PMWhite® Glabridin300. On the basis of more convenient application, it significantly improves the bioavailability of the product. Experimental data show that the bioavailability of PMWhite® Glabridin300 is 3.1 times that of ordinary Glabridin, which can help customers greatly reduce the cost of adding Glabridin.
| Product Name | INCI Name | ||
| PMWhite® Glabridin300 | HYDROXYPROPYL CYCLODEXTRIN, GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT, PIPER NIGRUM (PEPPER) SEED EXTRACT |
||
| Product ID | Specification | Minimal Package | Minimal Order Quantity |
| PMWT0201 | Glabridin≥10% | 100G | 100G |
2. PMWhite® Glabridin300 Manufacturer Specifications
| Items | Specifications |
| Glabridin | ≥10% |
| Physical Characteristics | |
| Appearance | White powder |
| Loss on drying | ≤10.00% |
| Residue on ignition | ≤7.00% |
| Solubility | Well soluble in water |
| Heavy Metals | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microbiological Tests | |
| Total plate count | ≤1000cfu/g |
| Total yeast & mold | ≤100cfu/g |
| Thermotoletant coliform | Not detected |
| Staphylococcus aureus | Not detected |
| Pseudomonas aeruginosa | Not detected |
3. PMWhite® Glabridin300 Mechanism for Skin Whitening
Normally, the cause of skin darkening is tyrosinase and reactive oxygen species. Tyrosinase can regularly produce melanin, making the skin black. And external stimuli (including common ultraviolet rays, inflammation, allergies, etc.) can cause excessive secretion of tyrosinase, which makes the skin black.
Glabridin is an excellent melanin inhibitor. Firstly, with the participation of glabridin, the activity of tyrosinase is significantly inhibited, thus blocking the biosynthesis of melanin in the skin. Secondly, glabridin can inhibit two proteins required in the process of melanin formation, thus blocking the enzymatic reaction to reduce the effect of melanin synthesis. Thirdly, glabridin can act as an endothelin antagonist to reduce the regulation of endothelin on the proliferation of melanocytes, thus reducing melanin production and achieving skin whitening effect.
Glabridin is currently a whitening ingredient with good curative effects and comprehensive functions, with good safety. However, due to the poor water solubility and low transdermal absorption, it is not possible to add a large amount of glabridin into cosmetics, which affects its efficacy.
4. Plamed PMWhite® Glabridin300 Test Data
- Bioavailability test of PMWhite® Glabridin300 VS normal water-soluble Glabridin
In order to solve the above shortcomings of glabridin, Plamed developed PMWhite® Glabridin300 and conducted a test. The test compared the transdermal penetration ability of PMWhite® Glabridin300 and water-soluble glabridin on the market. The experimental data showed that the cumulative permeation volume of PMWhite® Glabridin300 within 8 hours is 3.1 times that of ordinary water-soluble glabridin.
This means that the bioavailability of PMWhite® Glabridin300 independently developed by Plamed is 3.1 times that of ordinary water-soluble glabridin, which can greatly reduce the user’s cost.
- Whitening test—color of 3D simulated skin
The apparent color of the skin model was significantly whiter after 0.003% PMWhite® Glabridin300 treatment compared to the NC group.
- Whitening test—lightness of 3D simulated skin
The apparent lightness (L* value) of 0.003% PMWhite® Glabridin300 was significantly enhanced by 16.5% compared to the NC group.
- Whitening test—melanin of 3D simulated skin
The melanin particles were significantly reduced after 0.003% PMWhite® Glabridin300 treatment compared to the NC group.
5. Plamed PMWhite® Glabridin300 Characteristic
- The bioavailability is three times that of ordinary glabridin, PMWhite® Glabridin300 is cost-effective.
- Good water solubility, the solubility in water reaches 70g/100ml (water), which is convenient to be added into cosmetic formulas.
- Plamed uses high-quality Glycyrrhiza glabra root to extract.
6. PMWhite® Glabridin300 Reference Dosage
The recommended dosage of PMWhite® Glabridin300 is from 0.1% to 2%.
Through the stability test, it is found that the PMWhite® Glabridin300 is very easy to change color under alkaline conditions and has good stability under acidic conditions. However, when the pH is less than or equal to 5, trace substances will be precipitated. In creams, it is recommended to use PH≤6; in products such as lotions, essences, etc., it is recommended to use PH 5-6; it is not recommended to use in alkaline systems.
Figure. Different pH value of PMWhite® Glabridin300 water solution
7. PMWhite® Glabridin300 Application
PMWhite® Glabridin300 is generally applied in skincare products, including cream, facial mask, lotion, toner, serum, as well as emulsion. The following chart is the application examples in major cosmetic brands around the world.
| Country | Brand | Product |
| China | Grain Rain | Glabridin Brightening Essence,
Repair Pure Essence |
| LUCENBASE | Energizing Repair Cleanser | |
| FACE LIVE | Glycyrrhiza Glabra Astaxanthin Essence | |
| Japan | FREEPLUS | UV Day Protector A |
| Shiseido | Vital Perfection Intensive Wrinkle Spot Treatment | |
| France | Helena Rubinstein | Life Pearl Cellular |
| Lancome | Clarifique Pore Refining Cleansing Foam | |
| Chanel | Sublimage | |
| USA | La Mer | The Eye Concentrate |
| Arbuderm | Strength Bleaching Cream | |
| Korea | Paparecipe | Bombee Honey Mask |
| Dr. Jart + | Dermask Water Jet Vital Hydra Solution | |
| Shangpree | Phyto Essence UV Sunscreen | |
| Morocco | Lancaster | Sun Perfect Infinite Glow Illuminating Cream SPF50 |
8. PMWhite® Glabridin300 Reference Formula
Whitening Cream
| Phase | Ingredient | Content/% |
| A | Deionized water | Add to 100 |
| Cappo | 0.2 | |
| EDTA-2Na | 0.05 | |
| Glycerin | 3 | |
| Chondrus Crispus (Carrageenan) Extract | 0.05 | |
| Glycereth-26 | 1 | |
| PMSoothe® 9728 | 0.5 | |
| Portulaca Oleracea Extract | 0.5 | |
| B | M68 | 2 |
| A170 | 1 | |
| Ethanol | 1 | |
| Shea Butter | 0.5 | |
| Tocopherol | 1 | |
| NN | 3 | |
| Dimethicone | 2 | |
| Squalane | 6 | |
| C | TEA | 0.2 |
| D | EG | 0.3 |
| E | PMWhite® Glabridin300 | 1.00 |
| Water | 2.00 | |
| F | Phloretin | 0.50 |
| Butanediol | 2.00 | |
| G | Hexanediol | 0.5 |
| Butanediol | 2 |
Preparation process:
- Heatphase A to 85°C, homogenize and stir evenly.
- Heatphase B to 85°C, add to phase A, homogenize, stir, and cool.
- Cool down to 75°C and add phases C and D. Homogenize and stir evenly.
- Cool down to 45°C, add phases E, F, and G, and stir evenly.
9. PMWhite® Glabridin300 Safety
- CTFAhas specified GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT, PIPER NIGRUM (PEPPER) SEED EXTRACT, HYDROXYPROPYL CYCLODEXTRIN as raw materials for cosmetics.
- The plant raw materials listed in TheList of Used Cosmetic Ingredient approved by the CFDA in 2021 include GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT, PIPER NIGRUM (PEPPER) SEED EXTRACT, HYDROXYPROPYL CYCLODEXTRIN. There are no reports showing that is unsafe for external use.
- The historically highest dosage in rinse-offproducts were 5.5%, 2%, and 9%; the historically highest dosage in leave-on products were 5.5%, 0.375%, and 9%.
- PMWhite®Glabridin300 is practically non-toxic based on acute oral toxicity test.
- PMWhite®Glabridin300 has no irritation based on SN/T 2329-2009 “Cosmetic ocular irritant and corrosive HET-CAM test”
10. PMWhite® Glabridin300 Customer Feedback
PCR Glabridin: very effective for lightening, radiance after 10-day use
11. Packing and Storage
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
12. Related Reading
1. Licorice Extract Introduction
2. Glabridin-Licorice Root Extract for Skin Whitening
3. Glabridin Skin Benefits in Cosmetics
5. PCR Glabridin: Super Skin-Whitening Ingredient
6. Glabridin Whitening Benefits on Skin
7. Oman Customer feedback on PCR Glabridin: very effective for lightening, radiance after 10-day use
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional PMWhite® Glabridin300 manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good PMWhite® Glabridin300 and good PMWhite® Glabridin300 price will help customers make good terminal products and help customers win a lasting and broad market.
Other Skin-whitening Product List
| NO. | Product Name | Product ID | Specification | Product Image |
|---|---|---|---|---|
| 01 | Arbutin | PMB0101 PMB0102 | Alpha 99.5% Beta 99.0% |  |
| 02 | PCR Glabridin | PMB0705PCR | 10% |  |
| 03 | Kojic Acid Dipalmitate | PMB0801 | 99% |  |
| 04 | D-alpha Tocopherol Acetate | PMB0901 PMB0902 | 700IU 1300IU |  |
| 05 | Bakuchiol | PMKZ1501 | 98% |  |
| 06 | Grape seed extract | PMB1401 | 95%OPC |  |
| 07 | Ellagic Acid | PMB0401 | 98% |  |
| 08 | Glabridin | PMB0705，PMB0702 PMB0703，PMB0704 | 10%，40% 90%，98% |  |
| 09 | Glutathione | PMB1601 | 98% | |
| 10 | Ascorbic Acid 2-Glucoside | PMB1801 | 98% |  |
| 11 | Phloretin | PMB0301 | 98% |  |
| 12 | Lycopene | PMB1101 | 80% |  |
| 13 | Resveratrol | PMB0501 | 98% | |
| 14 | Green Tea Extract | PMB1501, PMB1502, PMB1503 | 95% EGCG, 70% oil-soluble polyphenols, 98% water-soluble polyphenols |  |
| 15 | Luteolin | PMB1301 | 98% |  |
| 16 | Chrysin | PMB1001 | 99% |  |
| 17 | Puerarin | PMB1201 | 98% |  |
| 18 | Escin | PMM0301 | 20%, 98% |  |
| 19 | Tetrahydrocurcumin | PMB0201 | 98% |  |
| 20 | Nicotinamide | PMB1501 | 99% |  |
| 21 | Curcumin | PMB2501 | 10% |  |
| 22 | Rhodiola-crenulata-extract | PMB2401 | 2% Salidroside |  |
