Pro-Xylane Manufacturer

1. Pro-Xylane Overview

Pro-Xylane, also known as hydroxypropyl tetrahydropyrantriol, is a glycoprotein mixture derived from xylose. Since xylose exists in large quantities in beech trees, it has the ability to promote the production of glucosaminoglycans, namely mucopolysaccharides (GAGs). Also, xylose can provide binding sites for GAGs, start the generation and assembly of GAGs in the skin, and improve the deficiency of GAGs caused by skin aging. Studies have shown that Pro-Xylane is easy to biodegrade, does not accumulate in organisms, and has no toxicity.

Plamed develops 2 kinds of Pro-Xylane, 30% liquid and 98% powder. Both are water-soluble It can be used in skincare products for anti-aging.

Product Name	CAS Number	INCI Name
Pro-Xylane	439685-79-7	HYDROXYPROPYL TETRAHYDROPYRANTRIOL
Molecular Weight	Molecular Formula	Molecular Structure
192.21g/mol	C8H16O5
Product ID	Specification	Minimal Package	Minimal Order Quantity
PMKZ2201	30% liquid	1kg	1kg
PMKZ2202	98% powder	1kg	1kg

2. Pro-Xylane Source

The inventor of Pro-Xylane, Dr. Maria DALKO-CSIBA, a scientist at the L’Oreal R&D and Innovation Center, is based on this characteristic of xylose, using a large number of beech and birch trees that exist in nature. In 1999-2000, he led the team to synthesize more than 200 kinds of xylose derivatives. Based on comprehensive consideration of factors such as efficacy, safety, stability and skin bioavailability, Pro-Xylane was finally successfully screened out. Nowadays, Pro-Xylane mainly obtained by chemical synthesis.

3. Pro-Xylane Manufacturer Specifications

98% Powder Specification

4. Pro-Xylane Benefits

• Anti-aging

Studies have proved that Pro-Xylane can exert biological effects at different layers of the skin

• Acting on the epidermis, Pro-Xylanecan promote the synthesis of various GAGs, and at the same time up-regulate the expression of hyaluronic acid receptor CD44 and syndecan, thereby activating the signal pathway mediated by GAGs. Clinical studies have shown that topical application of Pro-Xylane can effectively reduce transepidermal water loss, improve skin barrier function, and promote epidermal renewal, making the skin plump and radiant.

• At the Dermal-Epidermal Junction (DEJ), Pro-Xylanecan up-regulate collagen type IV (the main component of the lamina densa), laminin, type VII collagen (the main component of anchoring fibrils) and other key proteins. Then it can induce the expression of proteoglycanperlecan, and strengthen the tightness and stability of DEJ structure. Clinical studies have shown that in aging skin samples, the ultra-microscopic structure of DEJ presents the aging characteristics in several areas. After local application of Pro-Xylane, the DEJ structure of aging skin can be made more uniform and clear, the re-duplication of lamina densa is significantly reduced, making the skin structure stronger.

• In the dermis, Pro-Xylanecan promote the production of various GAGs such as hyaluronic acid and heparan sulfate. In addition, the up-regulation of the expression of type I procollagen and fibrillin-1 is observed, suggesting that the production of GAGs and collagen. They are both important dermal extracellular matrix components that maintain skin elasticity and firmness. Therefore, it has been proved in clinical research that topical application of Pro-Xylane can effectively improve the fine lines and wrinkles of the skin, and make the skin firm and elastic.

• Skin Repair

In vitro skin experiments, Pro-Xylane is able to reconstruct the complete structure of the epidermodermal layer, and it also had similar function as retinoic acid, enhancing the thickness of the stratum corneum and providing barrier function, but without irritation.

5. Plamed Pro-Xylane Characteristics

• No irritating odor, no toxicity, low content of acetic acid and borate, won’t affect the formulation.
• Good water solubility and stability, not easy oxidation, easily absorbed by skin.

6. Pro-Xylane Application and Reference Dosage

Pro-Xylane is mainly used in anti-aging, skin repair, anti-wrinkle skincare products, such as serum, facial mask, emulsion, toner, essence, cream, etc.

Pro-Xylane application cases in major cosmetic brands in the world:

7. Pro-Xylane Safety

• CTFAhas recognized HYDROXYPROPYL TETRAHYDROPYRANTRIOL as a raw material for cosmetics;
• The International Catalogue of Chinese Cosmetic Raw Materials Standardsin 2018 issued by HYDROXYPROPYL TETRAHYDROPYRANTRIOL.
• On the Announcement of Name List of Cosmetics Raw Materialpublished by CFDA in 2021 both include HYDROXYPROPYL TETRAHYDROPYRANTRIOL.

8. Package and Storage

Package: 1kg/bag, 1kg/bottle

Storage: Store in cool and dry place at room temperature, keep away from strong light.

9. Related Reading

1. Pro-Xylane Benefits for Anti-Aging

2. Top 5 Best Anti-aging Ingredients for Skincare

3.  Pro-xylane Anti-aging Uses for Skincare

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Pro-Xylane manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Pro-Xylane and good Pro-Xylane price will help customers make good terminal products and help customers win a lasting and broad market.