1. PMRepair®Centella Overview
Centella Asiatica Extract’s main active ingredients are asiaticoside, madecassoside, asiatic acid and madecassic acid. Madecassoside and madecassoside belong to triterpenoid saponins, and asiatic acid and madecassic acid belong to triterpene acid compounds. Scientific research has proved that Centella asiatica, as a traditional Chinese herbal medicine, has skin care effects such as repairing, anti-inflammation, whitening, and anti-oxidation. Centella asiatica is rich in a variety of biological active substances, and is a natural medicinal plant resource worthy of exploration and development.
PMRepair® Centella released by Plamed is a natural cosmetic material that can be soluble in water or butanediol with excellent skin repair and anti-inflammatory effects.
| Product Name | INCI Name | CAS No. | MOQ |
| PMRepair® Centella | CENTELLA ASIATICA EXTRACT | 84696-21-9 | 1kg |
2. PMRepair®Centella Botanical Source
Centella asiatica also known as Gotu Kola, is the dry whole plant of Centella asiatica (L.) Urban. It is a perennial creeping herbaceous plant with slender stems. Centella Asiatica is native to India and is now widely distributed in tropical and subtropical regions of the world. Centella asiatica has a medicinal history of more than 2,000 years in my country. Many other countries and regions, such as Madagascar, South Africa, India, Southeast Asian countries and South America, also use Centella asiatica as a brain medicine, diuretic, and leprosy and ulcer. The main active ingredients of Centella asiatica extract that can be used in cosmetics are asiaticoside and madecassoside, asiatic acid and madecassic acid.
3. PMRepair®Centella Technical Data Sheet
| Product Name | Product ID |
| PMRepair® Centella | PMRP0101 |
| Organoleptic Tests | |
| 70% Total Triterpenes (Asiaticoside + Madecassoside + Asiaticoside B) |
≥70% |
| Appearance | Off-white to pale yellow powder |
| Odor | Characteristic |
| Physical Characteristics | |
| Moisture | ≤10.0% |
| Ash content | ≤7.0% |
| Heavy Metals | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microbiological Tests | |
| Total of bacteria | ≤1000cfu/g |
| Yeast & mold | ≤100cfu/g |
| Pseudomonas aeruginosa | Not detected |
| Staphylococcus aureus | Not detected |
| Heat-resistant escherichia coli | Not detected |
4. PMRepair®Centella Mechanism & Effects
- Repair Skin Barrier
Plamed has done the test of in vitro 3D epidermis skin model repairing efficacy, using the anionic surfactant Sodium lauryl sulfate (SLS) to stimulate the 3D epidermal skin model to construct an in vitro skin injury model. After PMRepair® Centella sample is applied, the tissue morphology, filaggrin (FLG), loricrin (LOR) and transglutaminase 1 (TGM1) are used to evaluate the repairing efficacy of PMRepair® Centella.
The test results are as follows:
Based on the 3D epidermal skin model (EpiKutis®), compared with the control group, the tissue morphology of the sample PMRepair® Centella at a concentration of 0.15% was significantly improved, and the thickness of the living cell layer was significantly increased, with an increase rate of 49.39%. Filaggrin (FLG), loricrin (LOR), and transglutaminase 1 (TGM1) contents all increased significantly, with the increase rates being 150.00%, 646.15%, and 537.14% respectively. It indicates that PMRepair® Centella can improvetissue morphology at 0.15% concentration, promote skin tissue recovery and increase the content of barrier-related proteins (FLG, LOR, TGM1) to achieve repairing effects.
Based on skin barrier permeability test of zebrafish embryo, PMRepair® Centella has a significant skin barrier repair effect at a lower dose of 0.1%, the repairing rate is 53%; while Asiaticoside (95%) has no repairing effect or has a weak repairing effect at either low or high doses.
- Anti-inflammation & Anti-bacteria
NF-κB signaling pathway is closely related to inflammatory response and plays an important role in regulating cellular inflammatory response: when cells are stimulated, NF-κB can be activated, thereby causing inflammatory factors TNF-α, IL-1β, IL-2, IL-6, nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2)’s over-expression.
Relevant studies have found that Centella asiatica extract can down-regulate the expression of nitric oxide (NO), TNF-α, and IL-6 by inhibiting the NF-κB signaling pathway, thereby exerting anti-inflammatory effect. Centella asiatica extract can also play an anti-inflammatory role by regulating the heme oxygenase 1 (HO-1) signaling pathway, inhibiting the production of pro-inflammatory factors and the activity of peroxidase.
In addition, Centella asiatica extract has a certain inhibitory effect on Pseudomonas aeruginosa, Staphylococcus aureus, and acne bacillus. Asiatic acid can dissolve the outer wax film of bacteria to be killed by other drugs or body defense tissues. Asiatic acid and glycosides for external use can promote wound healing, stimulate granulation, promote epidermal keratinization or epidermal regeneration, and help generate connective tissue. Centella asiatica extract can reduce the production of pro-inflammatory mediators (IL-1, MMP-1), improve and repair the skin’s own barrier function, thereby preventing and correcting skin immune dysfunction.
- Anti-oxidation
Centella asiatica extract also has a strong antioxidant effect, which can inhibit free radical activity. Oxidation is one of the important causes of skin aging. Radiation and air pollution in the external environment will cause the body to produce free radicals. Free radicals are active substances that lack electrons. After entering the human body, they easily snatch electrons from cells and cause cell distortion. This is the root cause of human aging and disease. Specialists studied the antioxidant activity and total phenolic compounds of the roots, leaves and petioles of four species of Centella asiatica, and the results showed that the leaves and roots of Centella asiatica had high antioxidant activity, and their antioxidant activity was closed to that of Tocopherol.
5. Plamed PMRepair®Centella Characteristic
- Cost-effective, the test concentration and price are one-third of 95% asiaticoside, but the repairing effect is far more than asiaticoside.
- Soluble in water or butanediol, easy to be formulated into cosmetics.
- High quality centella asiatica plant as the raw material for extraction.
6. PMRepair®Centella Dosage
| PMRepair® Centella | Recommended dosage |
| Leave-on cosmetics | 0.1%~0.5% |
| Wash-off cosmetics | 0.1%~0.5% |
Note: PMRepair® Centella at a concentration of 0.15% has been tested with very good efficacy results based on 3D epidermal skin modeling, so the recommended dosage is 0.1%-0.2%.
7. PMRepair® Centella Solubility
The water solution of PMRepair® Centella is clear and transparent, but the solution will be cloudy and opaque when stand for a long time.
Therefore, the following dissolution methods can be chosen:
① 35% butylene glycol, 65% deionized water. The solution is clarified and transparent after a long time.
② Pure water. At 0.1% and 0.2% concentration and PH value below 6, the aqueous solution is clear and transparent.
From left to right: 0.1% aqueous solution; 0.1% aqueous solution + 0.5% phenoxyethanol;
0.1% aqueous solution, PH=5; 0.1% aqueous solution, PH=6.
From left to right: 0.2% aqueous solution; 0.2% aqueous solution + 0.5% phenoxyethanol;
0.2% aqueous solution, PH=5; 0.2% aqueous solution, PH=6.
8. PMRepair®Centella Safety
- China has included Centella Asiatica Extract in The International Catalogue of Chinese Cosmetic Raw Materials Standards (2010 edition) published by CAFFCI and On the Announcement of Name List of Cosmetics Raw Materialissued by CFDA in 2014. There are no reports showing that is unsafe for external use.
- CTFAhas specified Centella Asiatica Extract as a raw material for cosmetics.
- Centella Asiatica Extractis listed in The List of Used Cosmetic Ingredient approved by the Ministry of Health of the People’s Republic of China in 2001.
- Plalmed tested cytotoxicity assay of PMRepair®Centella, and the results showed that PMRepair® Centella based on keratin-forming cells does not show significant cytotoxicity in the range of 0.1563 mg/mL.
9. Packing and Storage
Package: Packed in aluminum foil bag, 1kg/bag.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional Skin Repair Ingredient PMRepair® Centella manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Skin Repair Ingredient PMRepair® Centella and good Skin Repair Ingredient PMRepair® Centella price will help customers make good terminal products and help customers win a lasting and broad market.
