1. Xanthohumol Overview
Xanthohumol (XN) is a flavonoid. It is currently only found in hops. The content of Xanthohumol in hops is 0.1% to 1%. Xanthohumol is slightly soluble in water, and easily soluble in ethanol. It has a variety of pharmacological activities. It is widely used in medicine and health care industries. Meanwhile, Xanthohumol can inhibit melanin production induced by xanthine via inhibiting the expression of tyrosinase and related enzymes. Its elimination rate of oxygen free radicals in the body is several times higher than other antioxidants; its antioxidant activity is stronger than VE, 200 times stronger than resveratrol. It can effectively scavenge harmful free radicals in human body. Xanthohumol inhibits the activity of cyclooxygenase and lipoxygenase; it kills diseased bacteria, viruses and fungi, and alleviates skin acne problem. Therefore, Xanthohumol shows prospective application in the cosmetics market. Plamed develops 5% Xanthohumol that is cosmetic grade.
| Product Name | CAS Number | INCI Name | |
| Xanthohumol | 6754-58-1 | Xanthohumol | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| C21H22O5 | 354.396g/mol |  |
|
| Product ID | Specificcation | Minimal Package | Minimal Order Quantity |
| PMQD0501 | 5% | 1KG | 1KG |
2. Xanthohumol Source
Hops (Latin name: Hunulus lupulus Linn.) are the dried ripe flowers of moraceae plant hop. They are one of the main raw materials for brewing beer. They can provide beer with unique aroma and bitterness as well as antiseptic effect. Hops are mainly distributed between 35°-55° north and south of equator. The plant originates from Europe, America and Asia. There are wild hops in northern Sinkiang, and artificial cultivation in northeast and north China. Hops are also a kind of medicinal and edible homologous plant with a long history of use. They are mainly used as a spice, seasoning, and can also be used for making tea. People use female inflorescence of hops as medicine, which can improve digestion, help diuresis, and relieve anxiety. The plant is rich in hop resin, hop oil, polyphenols, flavonoids and other medicinal ingredients. It has antibacterial, sedative, and other pharmacological functions for treating tuberculosis, neurasthenia, leprosy. It is of great value in the medical and health care industries.
3. Xanthohumol Manufacturer Specifications
| Product Name | Specificcation |
| Xanthohumol | 5% HPLC |
| Item | Specification |
| Organoleptic Characteristics | |
| Appearance | Fine powder |
| Color | Yellow brown |
| Odor | Characteristic |
| Taste | Characteristic |
| Extract solvent | Ethanol &water |
| Physical Characteristics | |
| Particle size | 98% through 80 mesh |
| Loss on drying | ≤5.00% |
| Ash content | ≤5.00% |
| Bulk density | 50-60g/100ml |
| Heavy Metals | |
| Heavy metals | ≤10ppm |
| As | ≤2ppm |
| Pb | ≤2ppm |
| Microbiological Tests | |
| Total plate count | ≤1000cfu/g |
| Yeast & mold | ≤100cfu/g |
| E. coli | Negative |
| Salmonella | Negative |
| Staphylococcus | Negative |
Xanthohumol HPLC Chromatogram
4. Xanthohumol Manufacturer Process Flow Chart
5. Xanthohumol Benefits
- Anti-oxidation
German scientists have shown that Xanthohumol can scavenge oxygen free radicals in the body. It is several times more than other antioxidants. It is more anti-oxidative than VE and 200 times more powerful than resveratrol. It is one of the strongest antioxidants known. It can effectively remove harmful free radicals in human body and delay skin aging. Test results indicate that the antioxidant properties of Xanthohumol can be enhanced when it is combined with citric acid, sodium citrate and vitamin C.
- Whitening skin
Xanthohumol inhibits the expression of tyrosinase and related enzymes to stop melanin formation induced by xanthine. Thereby it can exert skin-whitening effect.
- Anti-bacterial and anti-inflammation
Xanthohumol can inhibit the activity of cyclooxygenase and lipoxygenase, so it has antibacterial and anti-inflammatory effect. It can kill bacteria, viruses and fungi. Studies have suggested that Xanthohumol and isoxanthohumol can fight against cytomegalovirus, herpes HSV-1 and HSV-2 viruses. And the effect of Xanthohumol is significantly stronger than that of isoxanthohumol. It can relieve skin acne problem.
Minimal inhibitory concentration of Xanthohumol on some bacteria MIC
| Bacteria | Minimal inhibitory concentration |
| Staphylococcus aureus | 1mg/mL |
| Staphylococcus epidermidis | 3mg/mL |
| Streptococcus pyogenes | 1mg/mL |
| Propionibacterium acnes | 3mg/mL |
6. Xanthohumol Application & Related Studies
Cosmetics
- Xanthohumol can be antibacterial and anti-inflammatory, so it can be used to treat acne and other facial diseases.
- It has a strong inhibitory effect on the activity of tyrosinase. It can be used in whitening skin care products.
- Xanthohumol is an antioxidant that can be used in sunscreen to reduce UV damage to the skin.
- Xanthohumol has significant anticancer properties to prevent skin cancer.
Studies on Xanthohumol and cosmetics
| Test item | Concentration | Result |
| Elimination of singlet oxygen radicals | / | The equivalent of 14.1 vitamin E |
| Elimination of lipid peroxide | / | The equivalent of 2.1 Trolox |
| Elimination of water – soluble lipid peroxide | / | The equivalent of 1.4 Trolox |
| Inhibition of tyrosinase activity | 5μmol/L | Inhibition rate: 60.3% |
| Inhibition of apoptosis by UVB irradiation | 5μmol/L | Inhibition rate: 51.1% |
| Inhibition of the activity of b-16 melanocytes | 3×10-6 | Inhibition rate: 47%±6% |
| Inhibition of MMP-1 activity of metalloproteinase | 30μg/mL | Inhibition rate: 65% |
| Inhibition of MMP-8 activity of metalloproteinase | 30μg/mL | Inhibition rate: 70% |
- Xanthohumol application cases in major cosmetic brands worldwide:
| Country | Brand & Product | Main ingredient |
| USA | Peter Thomas Roth Cosmetics
Body lotion |
Xanthohumol, Cetearyl Alcohol, Glycerin, Ascorbic Acid, Vitamin E Acetate, Joe Pine Cone Extract, Bergamot Extract, Chamomile Extract, Rosemary Leaf Extract. |
| JOSON Natural
Organic tea tree shampoo |
Xanthohumol, Chamomile Extract, Salvia Officinalis Extract, Wheat Germ Oil | |
| LAVO
Moisturizing cream |
Xanthohumol, Rosemary, Hyaluronic Acid, Chamomile Allantoin, Aloe Extract, Wheat Germ, Avocado Oil. | |
| EO Products
Shower gel |
Xanthohumol, Aloe Extract, Tocopherol, Calendula Extract, Chamomile Extract, Fig Extract, | |
| Germany | Kneipp
Hop bath essential oil |
Xanthohumol, Sodium Chloride, Polysorbate 20, Valerian Root Oil, Citronella Oil, Lavender Oil, Eucalyptus Globulus Leaf Oil, Camphor, Citronellol, Limonene, |
| Hungary | Eminence Organic Skincare
Herbal antioxidant essence |
Xanthohumol, Yucca Extract, Aliphatic Acid, Flax Seed Extract. |
7. Xanthohumol Reference Formula
Shampoo:
| Ingredient | Content（%） | Ingredient | Content（%） |
| Xanthohumol | 1.0 | BS-12 | 2.5 |
| C10-16-(Alkyl) alcohol ethoxylate sulfuric acid | 20.0 | Lactic acid | 0.1 |
| Coconut oil fatty alcohol diethanolamine | 4.0 | TA-40 | 3.0 |
| Pigment, preservative, UV-absorber | Appropriate | Fragrance | 0.6 |
| Antidandruff and antipruritic | 1.0 | Water | Add to 100 |
Hand cream：
| Ingredient | Content（%） | Ingredient | Content（%） |
| Xanthohumol | 0.3 | Cera alba | 8.0 |
| Lanolin | 5.0 | Mink oil | 4.0 |
| Sunflower seed oil | 20.0 | Bergamot oil | 0.3 |
| Jasmine flavour | 0.5 | Water | 61.8 |
| Preservative | 0.1 | ||
8. Xanthohumol Safety
- Toiletry and Fragrance Association(CTFA) and CAFFCI’s 2010 edition-The Catalog Of the International Cosmetics Raw Material Standard English Name both specify Xanthohumol as cosmetics component. There is no report showing its insecurity.
- Xanthohumol is included in The List of Used Cosmetic Ingredient approved by the Ministry of Health of the People’s Republic of China in 2001.
- Xanthohumol is listed on Japan’s Functional Cosmetic Ingredients.
9. Plamed Xanthohumol Characteristic
Comprehensive development and utilization of Xanthohumol. First extract hops resin by supercritical CO2; then extract Xanthohumol from wasted hpos. So it has a cost advantage.
10. Packing and Storage
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and heat.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional Xanthohumol manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Xanthohumol and good Xanthohumol price will help customers make good terminal products and help customers win a lasting and broad market.
