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In 2024, according to media, the discussion about oily skin and oil control on social media continued to be hot, especially the search volume of the keyword “oily sensitive skin” increased by 275.1% year-on-year, showing that consumers are highly concerned about solving the problem of oily sensitive skin. Oily sensitive skin is a special type of skin, which is both prone to oiliness and sensitive to external stimuli. In the face of the demand of oily sensitive skin consumers, the market is in urgent need of a monomer plant material that can effectively control oil secretion and soothe the skin at the same time. Plamed has discovered that the Chinese speciality plant Scutellaria baicalensis has great potential to solve the problem of oil-sensitive skin. Scutellaria baicalensis extract benefits for oily sensitive skin is known for its anti-inflammatory effects. Plamed develops PCR® Supramolecular Scutellaria Baicalensis Extract, not only has a strong anti-inflammatory effect, but also an excellent oil-control effect.
- Scutellaria Baicalensis Extract Benefits For Oil-Control
5α-reductase is an important metabolic enzyme in the skin that irreversibly converts testosterone to dihydrotestosterone (DHT), which induces the sebaceous glands to overproduce oil. Therefore, the 5α-reductase activity inhibition rate can be tested to determine whether the substance to be tested has the ability to alleviate the overproduction of oil by sebaceous glands. PCR® Supramolecular Scutellaria Baicalensis Extract’s in vitro ability to inhibit the 5α-reductase enzyme even exceeds or is close to PCA zinc and yeast zinc, which are the mainstream in the market for oil control, with the following results:
Figure. Scutellaria baicalensis extract benefits for inhibiting 5α-reductase
The test results showed that 0.1%, 0.5% and 1% of PCR® Supramolecular Scutellaria Baicalensis Extract inhibited 5α-reductase by 16%, 56.71% and 69.41%, respectively, indicating that it has oil-controlling efficacy. Moreover, at the same dose of 0.5%, the oil-controlling ability of PCR® Supramolecular Scutellaria Baicalensis Extract exceeded that of PCA zinc (99%).
In vitro biochemical experiments have demonstrated that PCR® Supramolecular Scutellaria Baicalensis Extract has an outstanding inhibitory effect on 5α-reductase, so in cells, does it work to inhibit the formation of lipid droplets? Let’s look at the data:
Figure. Scutellaria baicalensis extract benefits for inhibiting lipid droplets
Based on human sebaceous gland cells, the relative inhibition of lipid droplet formation by the sample PCR® Supramolecular Scutellaria Baicalensis Extract at concentrations of 0.008%, 0.016%, 0.031%, and 0.063% were 28.93%, 37.42%, 41.57%, and 51.33%, respectively. The oil-control efficacy of PCR® Supramolecular Scutellaria Baicalensis Extract was close to that of PCA zinc.
The oil-control data from the above two experimental models can prove that PCR® Supramolecular Scutellaria Baicalensis Extract is likely to be a strong oil-control ingredient that is seriously underestimated, and deserves to be demonstrated by more scientific research institutes and enterprises from different experimental models to prove its superb oil-control ability.
If it is to be used in the field of oily sensitive skin, it is not enough to have excellent oil-control effect, but it should also have excellent soothing effect. In fact, Scutellaria baicalensis has been proven to be an excellent anti-inflammatory ingredient in both the pharmaceutical and beauty fields. Here share with you the anti-inflammatory and redness repairing effects of PCR® Supramolecular Scutellaria Baicalensis Extract, especially the redness repairing data, which is unexpected.
- Scutellaria Baicalensis Extract Benefits For Anti-Inflammation
This test is based on LPS stimulation of macrophages followed by the addition of the sample to be tested, PCR® Supramolecular Scutellaria Extract, and then testing the levels of individual inflammatory factors or mediators in order to evaluate whether the sample has an anti-inflammatory and soothing effect.
Figure. Scutellaria baicalensis extract benefits for anti-inflammation
The inhibition rates of the sample PCR® supramolecular Scutellaria baicalensis extract against inflammatory factors (IL-6, IL-1β) and inflammatory mediators (PGE2) were 96.87%, 77.80%, and 91.09%, respectively, at the concentration of 0.5%, which showed soothing efficacy. The inhibition rate of PCR® Supramolecular Scutellaria Baicalensis Extract against some of the inflammatory factors at the maximal safe concentration was better than that of dexamethasone.
The test utilized changes in skin neutrophil counts before and after treatment with the transgenic neutrophil green fluorescent strain of zebrafish (MPX) to detect whether the sample PCR® Supramolecular Scutellaria Baicalensis Extract has anti-inflammatory and soothing properties. The results were as follows:
| Test efficacy | Samples name | Concentration/% | Efficacy/% | p value | Test result |
| Anti-inflammation and soothing | Asprin | 0.01 | 33 | ＜0.001 | Significant |
| PCR® supramolecular
Scutellaria baicalensis extract |
0.1 | 87 | ＜0.01 | Significant |
Based on zebrafish tests, PCR® Supramolecular Scutellaria Baicalensis Extract at 0.1% had a soothing effect on inflammation, with a soothing effect of 87%.
- Scutellaria Baicalensis Extract Benefits For Anti-Redness
In addition to in vitro studies, Plamed’s exclusive exploration of PCR® Supramolecular Scutellaria Baicalensis Extract on human redness repair data:
Figure. Scutellaria baicalensis extract benefits for anti-redness
After the subjects were modelled with infrared light, the use of 1% PCR® Supramolecular Scutellaria Baicalensis Extract for 1h and 2h reduced skin haemoglobin by 24.44% and 27.33%, respectively; and the effect of redness repair exceeded that of an famous repair product.
- Scutellaria Baicalensis Extract Safety
PCR® Supramolecular Scutellaria Baicalensis Extract benefits for oil control, anti-inflammatory and redness repair effects on oily sensitive skin caused by whiteheads, blackheads, enlarged pores, acne and redness and other skin problems are no less than the mainstream raw materials in the market. Of course, in addition to good efficacy in the application of oily sensitive skin, the safety of the ingredients is a key point. According to the ‘Technical Code for Cosmetic Safety’ (2015 edition), we did the safety test of PCR® Supramolecular Scutellaria Baicalensis Extract, the results show that 30 people use 2.35% concentration of PCR® Supramolecular Scutellaria Baicalensis Extract after 48h have no adverse skin reactions.
- Scutellaria Baicalensis Extract Stability
Although Scutellaria baicalensis extract is excellent in terms of efficacy, the issue of their solubility has always been a challenge in the application. Traditionally, Scutellaria baicalensis extract is neither water nor alcohol soluble, which limits its wide application in cosmetic formulations. Plamed’s original supramolecular capture technology not only solves the solubility problem of Scutellaria baicalensis extract, but also enhances the purity of the active substance, reduces the ionicity, and greatly improves the stability of Scutellaria baicalensis extract after water solubility.
After 3 months of storage of PCR® supramolecular Scutellaria baicalensis extract solution at different pH (pH<9) at low temperature (4℃), room temperature (20-30℃) and high temperature (45℃), the colour of the solution becomes lighter and obvious precipitation occurs at pH 8-10, which is less stable; a very small amount of precipitation occurs at pH4, which is more stable; and under the rest of the conditions, the solution is clear and transparent, which is good stability. Therefore, it is suggested that the product should be used in the range of pH 5-7 and stored at room temperature or low temperature.
In summary, Scutellaria baicalensis extract not only shows excellent effects in oil control, anti-inflammation and redness repair, but also its solubility and stability problems have been solved through Plamed’s innovative technology. This makes Scutellaria baicalensis extract a valuable resource for oily sensitive skin care, and its market potential and application value should not be ignored. In recent years, Scutellaria Baicalensis Root Extract has seen year-on-year growth in the number of registration on NMPA and social media voices, with a 24.36% increase over the past year. This indicates that consumers are gradually recognizing the efficacy of Scutellaria baicalensis root extract in skin care products.
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