Phloretin manufacturer

1. Phloretin Overview

Phloretin is a plant polyphenol with a dihydrochalcone structure. It is present in the peel and root bark of succulent fruits such as apples and pears, and in various vegetable juices. Plamed is extracted from high-quality apple bark and peel, and is cosmetic raw material of 98% specification. Phloretin has abundant biological activities, such as anti-oxidation, anti-tumor, blood sugar lowering, blood vessel protection, etc. And Phloretin can inhibit tyrosinase activity, enhance skin permeability. It also helps other whitening ingredients to enter the skin to exert their biological activity. At the same time, Phloretin can scavenge free radicals, reduce the keratinocytes damage caused by ultraviolet rays; and it also has antibacterial activity. It has many beauty effects including anti-aging, whitening skin, anti-inflammation, and removing acne. Phloretin can dilute pigmentation and whiten skin. Its effect is better than other common whitening agents such as kojic acid and arbutin.    It is a new favorite whitening agent in cosmetics market.

Product Name	CAS Number	INCI Name
Phloretin	60-82-2	Phloretin
Molecular Weight	Molecular Formula	Molecular Structure
274.269g/mol	C15H14O5
Product ID	Specificcation	Minimal Package	Minimal Order Quantity
PMB0301	98%	1KG	1KG

2. Phloretin Botanical Source

Apple (Latin name: Malus domestica) is rosaceae plant of the genus apple subfamily. The plant is deciduous tree. Apple is native to central and southeast Europe, central and western Asia, and Sinkiang of China. Apple trees grow well in cool, dry temperate regions. They are mainly distributed in the Loess Plateau, Bohai Bay, Yellow River and Southwest Plateau. China is the world’s largest producer and consumer of apple. Overseas countries such as the United States, Turkey, Italy, France, Poland, Germany and Russia also have large areas of apple trees. Apple is rich in carbohydrates, vitamins and micronutrients. It is given the nickname “fruit of wisdom” and “fruit of memory”. It can be used for juicing and brewing.

3. Phloretin Manufacturer Specifications

Product Name	Specification	Color
Phloretin	98%	White

Items	Specification
Assay	≥98%
Appearance	White powder
Physical Characteristics
Particle Size	98% through 80 mesh
Moisture	≤1.00%
Ash Content	≤1.00%
Heavy Metals
Heavy metals	≤10ppm
Arsenic	≤1ppm
Lead	≤1ppm
Microbiological Tests
Total Plate count	≤1000cfu/g
Yeast & mold	≤100cfu/g
Escherichia coli	Negative
Staphylococcus	Negative
Salmonella	Negative

4. Phloretin Manufacturer Flow Chart

5. Phloretin Benefits

• Skin-whitening

The research and development of whitening agents is mainly dominated by inhibition of tyrosinase activity. Phloretin can inhibit the activity of tyrosinase. Its IC50 is 37.5 μmol/L. Study has found that the inhibition rate of 0.3% Phloretin on tyrosinase is as high as 98.2%. Its IC50 is 0.05%. Its inhibitory effect on tyrosinase is superior to the common whitening agents (kojic acid and arbutin). And further study shows Phloretin can greatly improve the inhibition rate to 100%, when blending with common tyrosinase inhibitor.

• Anti-inflammation and anti-bacteria

Studies have shown that Phloretin can inhibit the production of inflammatory factors, chemokine factors and differentiation factors. It has a certain anti-inflammatory effect; and it is also a flavonoid compound with antibacterial activity. Phloretin can inhibit the ability of monocytes to adhere to keratinocytes. It blocks the phosphorylation of signal protein kinase AKT and MAPK. Thus it can exert the anti-inflammatory effect. On the one hand, Phloretin acts on the enzyme protein system in bacteria; and it affects the energy metabolism of bacteria. On the other hand, it interferes with proteins synthesis inside the cells, which causes the metabolic disorders inside the cells, and finally leads to the death of bacteria.

• Sun block

Studies have found that Phloretin not only absorbs UV rays directly, but also enhances the expression of nucleotide resection repair genes. Also it slows the formation of pyrimidine dimers induced by UVB, the degradation of glutathione and cell death. Phloretin reduces the damage of ultraviolet to keratinocytes. Addition of Phloretin to the basic formulation of cosmetics can improve the SPF and SPA values of cosmetics. In addition, a mixture of Phloretin, VC and ferulic acid can protect human skin from UV damage. It can provide light protection for human skin.

• Anti-oxidation

Phloretin is a flavonoid compound with dihydrochalcone structure. It has 4 phenolic hydroxyl groups. Its unique structure determines its strong antioxidant activity. In vitro experiment indicates that Phloretin has the ability to inhibit mitochondrial lipid per-oxidation; and it removes DPPH and ABTS free radicals. Its antioxidant mass concentration of grease is 10.30mg/L. Phloretin itself not only has antioxidant effect, but also can be combined with existing antioxidants to improve the anti-oxidation effect.

• Moisturizing

In recent years, researchers have found that plant-derived compounds containing hydroxyl, carboxyl and other polar groups have a moisturizing effect. The four hydroxyl groups contained in the Phloretin molecules can form hydrogen bonds with water molecules. It can absorb water and have potential moisturizing effect. Therefore, Phloretin can also be used as a natural moisturizer in moisturizing cosmetics.

• Anti-hair loss

Soybean adipose oxygenase is one of the important enzymes in the lipid oxidation process. And it is also involved in skin’s inflammatory reaction; it is one of important enzymes that affects hair loss. Foreign studies have shown that Phloretin can inhibit the activity of soybean adipose oxygenase. Thereby it reduces hair loss due to premature entry into senility. Thus, Phloretin can be added to shampoo and conditioner as a raw material for anti-hair loss.

6. Pharmacological studies of Phloretin and cosmetics

Test Item	Concentration	Result
Elimination of free radical DPPH	32umol/L	Elimination rate: 74.6%
Inhibition of lipid peroxidation	13umol/L	Inhibition rate: 53%
Promotion of  collagen 4 production	25ug/mL	Promotion rate: 201.6±20.6 (blank 100)
Protection against apoptosis of keratinocytes	400ug/mL	Protection rate:51.3%v9.6%
Promotion of ceramide production	2umol/L	Promotion rate: 164(blank 100)
Inhibition of tyrosinase activity	0.05%	Inhibition rate: 82.2%
Inhibition of hyaluronidase activity	100ug/mL	Inhibition rate: 93.5%
Inhibition of 5 α reductase activity		IC50: 84.3ug/mL
Inhibition of activity of mmp-1 metalloproteinase	5umol/L	Inhibition rate: 78%
Inhibition of interleukin-4 production		IC50: ＞30umol/L
Inhibition of activity of hexosaminidase	100ug/mL	Inhibition rate: 93.5%
Inhibition of moisture evaporation through epidermis by applying Phloretin	50umol/L	Inhibition rate: 25%(compare to blank)

7. Plamed Phloretin Characteristic

• Use high-quality apple tree bark and peel as raw material;
• Environment protection: no emission of hazardous substances in the extraction process;
• Plamed Phloretin’s color is more white, and its purity is higher;
• Plamed Phloretin has a good solubility. Its water solution is clear and transparent; it is easy to be absorbed by skin.

8. Phloretin Application and Reference Dosage

Phloretin is widely used in facial mask, emulsion, essence, face cream, sunscreen, shampoo, conditioner and other types of cosmetics.

Product	Reference Dosage
Phloretin 98%	0.3%-2.0%

 

Phloretin application cases in major cosmetic brands in the world:

Country	Brand	Product
USA	Skin Ceuticals	Skin Ceuticals Phloretin CF
		Skin Ceuticals AOX+Eye Gel
	Amalia	Antioxidant Milk
	PURE BioDerm	Antioxidant Super Serum
	Avon	Retroactive Youth Extending Serum
		Renew Clinical Collagen 3D
Japan	SK2	STEMPOWER

 

9. Phloretin Reference Formula

Freckle removing toner：

Ingredient	Content（%）	Ingredient	Content（%）
Phloretin	0.05	Methylparaben	0.2
Propylene glycol	4.5	Ethylparaben	0.02
Ethanol	3.0	water	Add to 100
Glycerin	0.5

10. Phloretin Safety

• Phloretin is listed as a recognized safe substance by Flavor and Extract Manufactures Association of America (FEMA).
• Cosmetic, Toiletry &Fragrance Association (CTFA) has specified Phloretin as a cosmetics ingredient.
• Phloretin is included in The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014. No reports show its insecurity.

11. Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Phloretin manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Phloretin and good Phloretin price will help customers make good terminal products and help customers win a lasting and broad market.