1. Ethyl Ascorbic Acid Overview
Ethyl Ascorbic Acid is a vitamin C derivative obtained by hydrocarbylation. It is stable to light, heat, acid, alkali; and it is not easily oxidized by air. It is a chemically stable vitamin C derivative. Also it is soluble in water.
Ethyl Ascorbic Acid can block melanin formation by inhibiting tyrosinase activity. It has effect of whitening skin. Additionally, Ethyl Ascorbic Acid has strong antibacterial and anti-inflammatory effect. It can resist inflammation caused by sunlight. Meanwhile, it can improve the dullness of skin and repair skin cells. It promotes collagen production, and has antioxidant and anti-aging effect. Ethyl Ascorbic Acid has been widely used in whitening and anti-aging cosmetics.
| Product Name | CAS Number | INCI Name | |
| Ethyl Ascorbic Acid | 86404-04-8 | 3-O-ETHYL ASCORBIC ACID | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| 204.18g/mol | C8H12O6 |  |
|
| Product ID | Specificcation | Minimal Package | Minimal Order Quantity |
| PMB2201 | 99% | 1KG | 1KG |
2. Ethyl Ascorbic Acid Source
Ethyl Ascorbic Acid is synthesized from vitamin C. The following are two common synthetic methods:
| One-step synthesis | Three-steps synthesis | |
| Procedure | Ethyl Ascorbic Acid is obtained by directly hydrolyzing 3-hydroxyl group using vitamin C and ethyl methanesulfonate or diethyl sulfate as raw materials. | A series of reactions are carried out using vitamin C and acetone as raw materials and anhydrous copper sulfate as a catalyst to obtain Ethyl Ascorbic Acid. |
| Advantage | Less steps, simple operation. | Raw material is easy to get. Low cost, stable yield, high purity and easy to be industrialized. |
| Disadvantage | Hydroxyl group is replaced by many positions; and the product is difficult to be separated. It needs to be purified by column chromatography and is not suitable for industrial production. | / |
3. Ethyl Ascorbic Acid Manufacturer Specifications
| Product Name | Specification |
| Ethyl Ascorbic Acid | 99% |
| Items | Specification |
| Appearance | White crystalline powder |
| Assay | ≥99% |
| Physical Characteristics | |
| pH value (3% water solution) | 3.5–5.5 |
| Free of VC | ≤10ppm |
| Loss on drying | ≤0.5% |
| Ignition residue | ≤0.2% |
| Heavy Metals | |
| Heavy Metals | ≤10 ppm |
| As | ≤2ppm |
4. Ethyl Ascorbic Acid Advantage
Vitamin C has four hydroxyl groups in its structure. It cannot be directly absorbed by skin; and it is easily oxidized to cause discoloration. As a whitening agent, it is limited in use of cosmetics. Vitamin C ethyl ether is prepared by 3-hydroxyl hydrocarbylation:
It is a vitamin C derivative that does not change color; and it does not affect its biological activity.
Compared with other vitamin C derivatives, Ethyl Ascorbic Acid has advantages in solubility and pH stability, as shown in the following tables:
Comparison of vitamin C content and solubility
| Name | Molecular weight | Vitamin C content (%) |
Solubility |
| Ethyl Ascorbic Acid | 204.18g/mol | 86.3 | Water-soluble |
| Ascorbic Acid 2-Glucoside | 338.27g/mol | 52.0 | Water-soluble |
| Magnesium Ascorbyl Phosphate | 303.5g/mol | 49.3 | Water-soluble |
| Sodium Ascorbyl Phosphate | 358.08g/mol | 46.55 | Water-soluble |
As can be seen from the above table, Ethyl Ascorbic Acid has the highest vitamin C content, and has the smallest molecular weight. It is more favorable to be absorbed by skin.
Comparison of pH stability
| Name | pH |
| Ethyl Ascorbic Acid | 4.0-6.0 |
| Ascorbic Acid 2-Glucoside | 6.0-7.0 |
| Magnesium Ascorbyl Phosphate | 7.0-9.0 |
| Sodium Ascorbyl Phosphate | 8.0-10.0 |
Ethyl Ascorbic Acid is a relatively acidic substance compared to other vitamin C derivatives. It is more suitable for human skin property.
5. Ethyl Ascorbic Acid Benefits
Ethyl Ascorbic Acid is easily decomposed by enzymes after being absorbed by skin. Thereby it plays the role of vitamin C in skin care:
- Anti-aging
Ethyl Ascorbic Acid is effective against free radicals. It can resist damage caused by UVA and UVB. Ethyl Ascorbic Acid prevents skin cells from aging and damage. It can help body to reduce the harmful free radicals produced by metabolism, and effectively fight free radicals.
- Skin-whitening
Ethyl Ascorbic Acid directly can reduce melanin to colorless reduced melanin. Then it exerts effect of whitening skin and lightening spots. It is also capable of reducing o-quinone by its own antioxidant activity; and it inhibits catalase activity to achieve the effect of inhibiting melanin formation.
- Anti-inflammatory
Ethyl Ascorbic Acid promotes the synthesis and repair of collagen. It is effective against carbonation and saccharification. Thus it significantly resists inflammation on skin surface.
- Promote collagen synthesis
Ethyl Ascorbic Acid has the activity of repairing collagen (including repairing the composition and synthesis of collagen). It can promote formation of skin cells and synthesis of collagen according to the ratio of skin cells and collagen consumption. Therefore, it makes skin shiny and elastic.
6. Ethyl Ascorbic Acid Application and Reference Dosage
Ethyl Ascorbic Acid is widely used in whitening and anti-aging skin care products, such as lotion, cream, toner, mask, essence, etc. The recommended dosage in cosmetics is 0.5-3%.
| Application | Reference Dosage |
| Whitening | 2% |
Note:
- When pH value of Ethyl Ascorbic Acid is 3.0-6.0, the whitening and freckling effect is the best.
Ethyl Ascorbic Acid application cases in major cosmetic brands in the world:
| Country | Brand | Product |
| USA | KIEHL‘S | Corrective Dark Spot Solution
Corrective White Clarity Activating Toner |
| L’Oreal | Turn-Around Anti-Spot Essence | |
| GIORGIO ARMANI | Crema Nera Extrema Reviving Cream | |
| Australia | Clorisland | Pure Bright Radiant Essence Toner |
| China | OSM | Pearl Brightening Lotion
Pearl White Smoothing Lotion |
| Genuine Namir | Snow Rose Crystal Whitening Essence | |
| Beauty Plus | VC Whitening Lotion | |
| For Beloved One | Melasleep Whitening Ethyl Ascorbic Acid Toner | |
| Korea | SULWHASOO | Time-treasure Renovating Cream Ex |
| France | Garnier | Light Complete White Speed Super Essence |
| BIOTHERM | White D-Tox CC Base Evenness SPF50+ PA++ | |
| LANCOME | Absolute Precious Cells White Aura Serum
Blanc Expert Beautiful Skin Tone Brightening Cream |
|
| Japan | SHISEIDO | Anessa Perfect Uv Sunscreen A+
Cr Melanoreduce Cr Shiseido White Lucent Luminizing Infuser |
| FANCL | Whitening Essence
Whitening Mask |
|
| Dr.Ci.Labo | O2 Herbal Gel Oxygen Charge | |
| CLE DE PEAU | Beaute Brightening Serum Supreme L | |
| Thailand | Beauty Buffet | Whitening Body Lotion Co-Enzyme Q10 |
7. Ethyl Ascorbic Acid Reference Formula
- Sunscreen facial mask fluid
| Ingredient | Content (%) | Ingredient | Content (%) |
| Ethyl Ascorbic Acid | 0.5 | Hyaluronic Acid Oligomer | 0.2 |
| Butylene Glycol | 3 | Synthetic Egg White Powder | 2 |
| Aloe Extract | 0.8 | Scutellaria Baicalensis Extract | 5 |
| Propylene Glycol | 0.5 | Raspberry Ketone Glucoside | 0.3 |
| Glycerin | 2 | Macromolecular Hyaluronic Acid | 0.3 |
| Ginseng Extract | 3 | Liquorice Extract | 3 |
| Kojic Acid | 0.8 | Nano Titanium Dioxide | 1.5 |
| Water | Add to 100 |
Preparation method：
- Mix and dissolve ginseng extract, scutellaria baicalensis extract, and liquorice extract for 10-24 hours to obtain solution A.
- Mix propylene glycol with 1,2-butanediol to obtain solution B.
- Add hyaluronic acid oligomer, macromolecular hyaluronic acid, synthetic egg white powder, aloe extract, ethyl ascorbic acid to solution B. Disperse and mix by homogenizer to obtain solution C; dispersion speed of homogenizer is 10000 rpm; and for three times, each time is 5 seconds.
- Dissolve kojic acid, nano titanium dioxide, and raspberry ketone glucoside in one-third of water solution to obtain solution D.
- Add solution A to solution C, then add solution D, then add glycerin and the rest water to stir and dissolve. Stir in a homogenizer; disperse speed is 10,000 rpm. For three times, each time for 3 seconds. Then mask liquid is obtained.
- Anti-aging emulsion
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| Oil phase | Tocopherol Acetate | 0.2 | Methyl Glucose Sesquistearate | 1.5 |
| Kiwi Fruit Seed Oil | 3 | Flaxseed Oil | 3 | |
| Geraniu Essential Oil | 0.2 | Bay Laurel Essential Oil | 0.2 | |
| Cinnamon Essential Oil | 0.2 | |||
| Water phase | Ethyl Ascorbic Acid | 0.2 | Troxerutin | 0.2 |
| Butanediol | 10 | Carbomer | 0.15 | |
| Water | Add to 100 | |||
| Arginine | 0.15 | Solomonseal Rhizome P.E | 0.5 | |
| Benincasae Semen P.E. | 0.5 |
Preparation method：
- The oil phase ingredients are heated to 70-90°C; stir and dissolve, and pressurize 0.1-10 MPa.
- The water phase ingredients are heated to 70-90°C; stir to dissolve, and pressurize 0.1-10Mpa.
- Inject the water phase into the oil phase mixture; homogenize for 3-5 minutes, then stir for 15 to 45 minutes. Release the pressure, and cool down to 45°C, and then add arginine, solomonseal rhizome P.E, benincasae semen P.E., and stir evenly.
- Whitening essence
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| A Phase | Sodium Hyaluronate | 0.03 | 1,3-Butanediol | 4 |
| Propylene Glycol | 3 | Glycerin | 3 | |
| Deionized Water | Add to 100 | |||
| B Phase | Ethyl Ascorbic Acid | 2 | ||
| Fragrance | q. s. | Preservative | q. s. |
Preparation method：
The phase A is heated to 85°C. Stir until completely dissolve, and cool down to below 45°C. Then add phase B. After dissolving completely, stop stirring. And then obtain the essence.
8. Ethyl Ascorbic Acid Safety
- The CIR Expert Panel has experimentally concluded that Ethyl Ascorbic Acid is safe for use in cosmetics;
- In 2010, the Department of Health announced that ethyl ascorbic acid is a whitening ingredient that can be added to cosmetics. The dosage limit is 1-2%.
9. Packing and Storage
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional Ethyl Ascorbic Acid manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Ethyl Ascorbic Acid and good Ethyl Ascorbic Acid price will help customers make good terminal products and help customers win a lasting and broad market.
Other Skin-whitening Product List
| NO. | Product Name | Product ID | Specification | Product Image |
|---|---|---|---|---|
| 01 | Arbutin | PMB0101 PMB0102 | Alpha 99.5% Beta 99.0% |  |
| 02 | PCR Glabridin | PMB0705PCR | 10% |  |
| 03 | Kojic Acid Dipalmitate | PMB0801 | 99% |  |
| 04 | D-alpha Tocopherol Acetate | PMB0901 PMB0902 | 700IU 1300IU |  |
| 05 | Bakuchiol | PMKZ1501 | 98% |  |
| 06 | Grape seed extract | PMB1401 | 95%OPC |  |
| 07 | Ellagic Acid | PMB0401 | 98% |  |
| 08 | Glabridin | PMB0705，PMB0702 PMB0703，PMB0704 | 10%，40% 90%，98% |  |
| 09 | Glutathione | PMB1601 | 98% | |
| 10 | Ascorbic Acid 2-Glucoside | PMB1801 | 98% |  |
| 11 | Phloretin | PMB0301 | 98% |  |
| 12 | Lycopene | PMB1101 | 80% |  |
| 13 | Resveratrol | PMB0501 | 98% | |
| 14 | Green Tea Extract | PMB1501, PMB1502, PMB1503 | 95% EGCG, 70% oil-soluble polyphenols, 98% water-soluble polyphenols |  |
| 15 | Luteolin | PMB1301 | 98% |  |
| 16 | Chrysin | PMB1001 | 99% |  |
| 17 | Puerarin | PMB1201 | 98% |  |
| 18 | Escin | PMM0301 | 20%, 98% |  |
| 19 | Tetrahydrocurcumin | PMB0201 | 98% |  |
| 20 | Nicotinamide | PMB1501 | 99% |  |
| 21 | Curcumin | PMB2501 | 10% |  |
| 22 | Rhodiola-crenulata-extract | PMB2401 | 2% Salidroside |  |
