PCR® Supramolecular Scutellaria baicalensis extract Manufacturer

1. PCR® Supermolecule Scutellaria Baicalensis Extract Overview

2. Botanical Source

Scutellaria baicalensis is a perennial herb in the genus Scutellaria of the family Lamiaceae, and its dried roots have been used by the Chinese as a traditional medicine for more than 2,000 years. Now it is officially listed in the Chinese Pharmacopoeia. Scutellaria baicalensis is mainly composed of flavonoids, with the highest content of baicalin and baicalein. The dried root of scutellaria baicalensis is mainly used in cosmetics. Scutellaria baicalensis extract is widely used in anti-allergy and anti-inflammatory cosmetics, and can also be used as a cosmetic additive for whitening and freckle removal, sun-protection and anti-aging.

3. Technical Data Sheet

4. PCR^® Supermolecule Scutellaria Baicalensis Extract for oil control

• Mechanism

Excessive sebum secretion is the main factor that triggers many skin problems, and the main influence on sebum secretion is the disruption of hormone levels in the body. 5α-reductase is a membrane protease that depends on reductive coenzyme II (NADPH), which is an important androgen metabolising enzyme in the skin, and irreversibly converts testosterone (T) into the most active androgen Dihydrotestosterone (DHT). DHT can induce the synthesis of large amounts of oil in sebaceous gland cells and secretion to the outside of the cells as lipid droplets, affecting cellular function. It can irreversibly convert Testosterone (T) into the most active androgen Dihydrotestosterone (DHT), which induces sebaceous gland cells to synthesise a large amount of oil and secrete it out of the cell in the form of lipid droplets, which affects cellular function and leads to a variety of skin problems. Therefore, 1. reduce the level of DHT by inhibiting the activity of 5α-reductase enzyme, which can effectively alleviate the excessive oil secretion by sebaceous glands. 2. reduce the formation of lipid droplets by inhibiting the secretion of cellular sebum, so the content of lipid droplets is the main indicator of the degree of oil control.

• Oil control efficacy test: inhibit 5α-reductase

The test results showed that 0.1%, 0.5% and 1% of PCR® supramolecular Scutellaria baicalensis extract inhibited 5α-reductase by 16%, 56.71% and 69.41%, respectively, indicating that it has oil-controlling efficacy. Moreover, at the same dose of 0.5%, the oil-controlling ability of PCR® supramolecular Scutellaria baicalensis extract exceeded that of PCA zinc (99%).

• Oil control efficacy test: rescue lipid droplets content

Based on human sebaceous gland cells, the relative inhibition of lipid droplet formation by the sample PCR® supramolecular Scutellaria baicalensis extract at concentrations of 0.008%, 0.016%, 0.031%, and 0.063% were 28.93%, 37.42%, 41.57%, and 51.33%, respectively. The oil-control efficacy of PCR® supramolecular Scutellaria baicalensis extract was close to that of PCA zinc.

5. PCR^® Supermolecule Scutellaria Baicalensis Extract for Anti-redness

• Mechanism

Skin redness is usually caused by a variety of factors including, but not limited to, skin sensitivity, inflammatory responses, vasodilation or skin barrier damage. The mechanisms commonly used in cosmetics to eliminate redness can be broadly categorised as follows: 1. Anti-inflammatory and soothing effect: By reducing the inflammatory response of the skin, it can improve the skin’s anti-irritation ability, repair the skin with inflammation and damage, so as to reduce skin redness and swelling. 2. Vasomodulation: Reduces erythema on the skin surface by regulating vasodilation and constriction, reducing blood flow, or reducing the visibility of blood vessels by affecting the function of vascular endothelial cells. 3. Skin barrier repair: Repairing and strengthening the skin barrier function can reduce the penetration of external irritants, thus reducing skin dryness and irritation and improving redness.

• Anti-redness test

After the subjects were modelled with infrared light, the use of 1% PCR® supramolecular Scutellaria baicalensis extract for 1h and 2h reduced skin haemoglobin by 24.44% and 27.33%, respectively; and the effect of redness repair exceeded that of an famous repair product.

6. PCR^® Supermolecule Scutellaria Baicalensis Extract for Anti-inflammation

• Mechanism

Scutellaria baicalensis extract can down-regulate the activation of the nuclear transcription factor NF-κB (inflammatory signalling pathway) and inhibit its expression in the nucleus, thus inhibiting the expression of inflammatory factors and mediators, such as IL-1β, IL-6 and PGE2, and thus achieving anti-inflammatory effects.

• Anti-inflammation test against inflammatory factors

The inhibition rates of the sample PCR® supramolecular Scutellaria baicalensis extract against inflammatory factors (IL-6, IL-1β) and inflammatory mediators (PGE2) were 96.87%, 77.80%, and 91.09%, respectively, at the concentration of 0.5%, which showed soothing efficacy. The inhibition rate of PCR@supramolecular Scutellaria baicalensis extract against some of the inflammatory factors at the maximal safe concentration was better than that of dexamethasone.

• Zebrafish inflammation relief test

Based on zebrafish tests, PCR® supramolecular Scutellaria baicalensis extract at 0.1% had a soothing effect on inflammation, with a soothing effect of 87%.

7. PCR® Supramolecular Scutellaria baicalensis extract Advantages

• Strong efficacy

PCR® Supramolecular Scutellaria Baicalensis Extract is simultaneously anti-irritant, oil-controlling and redness-repairing, making it a natural botanical ingredient for oil-sensitive skin.

• High safety

The safety test of 2.35% PCR® supramolecular Scutellaria baicalensis extract was conducted according to the “Technical Specification for Cosmetic Safety” (2015 edition), and the results showed that 30 people had no skin adverse reactions 48 hours after using the sample.

• Good stability

After 3 months of storage of PCR® supramolecular Scutellaria baicalensis extract solution at different pH (pH<9) at low temperature (4℃), room temperature (20-30℃) and high temperature (45℃), the colour of the solution becomes lighter and obvious precipitation occurs at pH 8-10, which is less stable; a very small amount of precipitation occurs at pH4, which is more stable; and under the rest of the conditions, the solution is clear and transparent, which is good stability. Therefore, it is suggested that the product should be used in the range of pH 5-7 and stored at room temperature or low temperature.

8. PCR® Supramolecular Supermolecule Scutellaria Baicalensis Extract Dosage

9. PCR® Supramolecular Scutellaria Baicalensis Extract Market Application

In recent years, Scutellaria Baicalensis Root Extract has seen year-on-year growth in the number of registration on NMPA and social media voices, with a 24.36% increase over the past year. This indicates that consumers are gradually recognising the efficacy of Scutellaria baicalensis root extract in skin care products.

10. Packing and Storage

Package: Packed in 1kg aluminum foil bag or 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool and dry place and away from direct sunlight and oxidizing agents.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional PCR® Supramolecular Scutellaria baicalensis extract manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good PCR® Supramolecular Scutellaria baicalensis extract and good PCR® Supramolecular Scutellaria baicalensis extract price will help customers make good terminal products and help customers win a lasting and broad market.