Dipotassium Glycyrrhizinate manufacturer

1.Dipotassium Glycyrrhizinate Overview

Dipotassium Glycyrrhizinate is a derivative of glycyrrhizic acid. It belongs to the triterpenoid saponin compound. Dipotassium Glycyrrhizinate is extracted from licorice root. It contains hydrophilic groups and lipophilic groups; so it can reduce surface tension of aqueous solution, and has a strong foaming ability. As an anti-allergy, sunscreen, anti-freckle, whitening cosmetic functional additive, Dipotassium Glycyrrhizinate can effectively prevent skin inflammation; and it has sedative effect on inflammation caused by sunlight. It is widely used in cosmetics industry. Plamed Dipotassium Glycyrrhizinate adopts two detection methods: HPLC (70%) and UV (98%), which ensures the purity of cosmetic grade Dipotassium Glycyrrhizinate, and makes customers relieved, secure and unworried.

Product Name	CAS Number	INCI Name
Dipotassium Glycyrrhizinate	68797-35-3	Dipotassium Glycyrrhizinate
Molecular Weight	Molecular Formula	Molecular Structure
899.12g/mol	C42H60K2O16
Product ID	Specification	Minimal Package	Minimal Order Quantity
PMB0706	98% UV	1KG	1KG

2. Dipotassium Glycyrrhizinate Source

Licorice (Scientific name: Glycyrrhiza uralensis Fisch) belongs to leguminosae herbaceous perennial. It is also a traditional Chinese herb plant. Licorice mainly grows in arid, semi-arid sandy soil, desert edge and loess hilly area. Most of wild licorice in China is distributed in Sinkiang, Inner Mongolia, Ningxia, Gansu, Shanxi, and other places. There are a large number of artificial cultivation licorice areas in Sinkiang, Gansu, Inner Mongolia and Ningxia provinces. Licorice contains a variety of effective chemical components, such as liquiritin, glycyrrhizic acid, glycyrrhetinic acid, licorice flavonoids, liquiritigenin, etc. These components are mainly found in licorice root and bark. So the thick roots of licorice are major medicinal source commonly. Licorice extract is mainly used in the pharmaceutical, health care and cosmetics industries.

3. Dipotassium Glycyrrhizinate VS Glycyrrhizic Acid

	Dipotassium Glycyrrhizinate	Glycyrrhizic Acid
Source	Potassium derivatives of glycyrrhizic acid	Licorice root
Appearance	White powder	White crystalline powder
Molecular Structure
Solubility	Easily soluble in water; soluble in dilute ethanol, glycerol, propylene glycol; slightly soluble in anhydrous ethanol, ether.	Hard to be soluble in cold water; easily soluble in hot water; insoluble in grease; its hot water solution is gelatinous after cooling; soluble in propylene glycol.
Application	Whitening cosmetics, teeth care and hair care products	Food additives (Sweeteners, flavorings, flavor enhancers) and pharmaceuticals industry

4. Dipotassium Glycyrrhizinate Manufacturer Specifications

5. Dipotassium Glycyrrhizinate Manufacturer Process Flow Chart

6. Dipotassium Glycyrrhizinate Benefits

• Whitening

1) Inhibits active oxygen formation: Dipotassium Glycyrrhizinate is a flavonoid compound with strong antioxidant activity. Experimental study uses superoxide dismutase SOD as a control group, and the result shows that Dipotassium Glycyrrhizinate can effectively inhibit the production of active oxyge. 2) Inhibits tyrosinase: The IC50 of tyrosinase of Dipotassium Glycyrrhizinate is very low compared to the commonly used whitening ingredient. Dipotassium Glycyrrhizinate is a well-recognized strong tyrosinase inhibitor; it is more effective than some commonly used whitening agents. 3) Inhibits melanin production: Test selects the back skin of guinea pigs under UVB irradiation. The result indicates that white coefficient of skin pretreated with 0.5% Dipotassium Glycyrrhizinate is higher than that of the control group’s skin, and the effect is obvious. Thus Dipotassium Glycyrrhizinate has a significant inhibitory effect on melanin formation. It can be used to prevent skin pigmentation and melanin production after sun exposure.

• Anti-inflammation

The result of mouse ear swelling test shows that toothpaste containing Dipotassium Glycyrrhizinate can significantly inhibit xylene-induced ear swelling of mouse. So it has a strong anti-inflammatory effect for acute inflammation. The in vitro anti-inflammatory experiment of Dipotassium Glycyrrhizinate suggests that in a certain concentration range, Dipotassium Glycyrrhizinate inhibits cells from secreting inflammatory mediator NO and inflammatory cytokine IL-6, when it acts on LPS to stimulate RAW264.7 cells. And its inhibition function depends on a certain dosage. Therefore, Dipotassium Glycyrrhizinate has obvious anti-inflammatory activity in vitro.

7. Plamed Dipotassium Glycyrrhizinate Characteristic

• Plamed owns a foreign planting base, which ensures a stable supply;
• Through optimizing the process, a complete and thorough reaction is carried out;
• Plamed adopts Korean cosmetic standard that is more applicable to cosmetics raw material.

8. Dipotassium Glycyrrhizinate Application and Reference Dosage

Dipotassium Glycyrrhizinate can be added into all kinds of cosmetics, such as cream, toner, emulsion, essence, etc. It can neutralize or reduce toxic substances in cosmetics; also it can prevent allergic reactions to some cosmetics. Moreover, Dipotassium Glycyrrhizinatecan can be used in advanced hair care products and teeth care products (toothpaste and mouthwash).

Attention:

• The recommended dosage of Dipotassium Glycyrrhizinate in toothpaste is 1%-0.5%;
• Dipotassium Glycyrrhizinate is suitable for combination with alpha hydroxy acid, which can increases skin defense ability.

Dipotassium Glycyrrhizinate application cases in major cosmetic brands in the world:

9. Dipotassium Glycyrrhizinate Reference Formula

Anti-allergic emulsion：

Anti-allergic toner：

Shampoo：

Skin-repair cream：

10. Dipotassium Glycyrrhizinate Safety

• The FDA includes Dipotassium Glycyrrhizinate on the list of Generally Recognized As Safe (GRAS). It can be directly used as food additives.
• EU Cosmetics Directives and the Cosmetic Ingredient Review (CIR) Expert Panel both believe that Dipotassium Glycyrrhizinate is non-toxic and safe when used in OTC personal care products.
• Clinical trial shows that Dipotassium Glycyrrhizate doesn’t penetrate nor irritate the skin.

11. Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Dipotassium Glycyrrhizinate manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Dipotassium Glycyrrhizinate and good Dipotassium Glycyrrhizinate price will help customers make good terminal products and help customers win a lasting and broad market.

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