Paeonia Suffruticosa Root Extract

Paeonia Suffruticosa Root Extract Mechanism

• Anti-inflammatory

Paeonol can down-regulate the activation of nuclear transcription factor NF-κB (inflammatory signaling pathway) and inhibit its expression in the nucleus, thus inhibiting the expression of IL-1β, IL-6, TNF-α and PGE2. At the same time, Paeonol can inhibit the further expression of iNOS to stop the production of the inflammatory factor NO, thus achieving the anti-inflammatory effect [1].

• Anti-aging

Human skin is stimulated by external (ultraviolet, ultrasound, radiation, etc.) stimulation, the mitochondria will produce an excessive amount of oxygen free radicals (ROS), and excessive oxygen free radicals will cause an increase in the activity of elastase, so that the skin loses its elasticity; excessive oxygen free radicals will also promote the release of inflammatory factors and cause inflammation; excessive oxygen free radicals will also enhance the expression of protein hydrolases (MMP1,2,3,9,10), specific degradation of extracellular matrix components, damage to the normal structure of collagen fibers1 and elastin fibers, leading to wrinkles and other aging manifestations of the skin. Paeonol can directly react with oxygen free radicals and consume the excess oxygen free radicals in the body; at the same time, Paeonol can enhance the activity of antioxidant enzymes to rapidly eliminate oxygen free radicals. Thus, it can achieve the purpose of anti-oxidation and anti-aging.

• Whitening

Melanin is the enzyme tyrosinase that catalyzes the conversion of tyrosine to L-dopa, which then produces L-dopaquinone, resulting in melanin. paeonol inhibits tyrosinase activity, thereby inhibiting the production of melanin. Excessive production of melanin in the skin may lead to hyperpigmentation, resulting in dark skin and spots. Therefore, Paeonol can be used in cosmetics to whiten skin and remove spots.

• Anti-inflammation

Phenols in Paeonia Suffruticosa Root Extract have the effect of inhibiting the release of inflammatory mediators and cytokine expression, which can reduce the local immune response and the level of oxidative stress, thus reducing the symptoms of inflammation such as redness, swelling and heat sensation.

• Anti-aging

Paeonia Suffruticosa Root Extract contains antioxidants that scavenge free radicals and slow down skin aging. In addition, it has an inhibitory effect on metalloproteinases and elastases, and an activating effect on tissue proteases, which helps to revitalize the skin and slow down the aging process.

• Whitening

Anthocyanins in Paeonia Suffruticosa Root Extract can inhibit the synthesis of melanin and reduce the precipitation of melanin, so as to realize the effect of lightening pigmentation and improving skin tone.

PCR® Supermolecule Paeonia Suffruticosa Root Extract Efficacy Tests

• Anti-inflammation

Paeonol significantly inhibits the production of TNF-α (Tumor Necrosis Factor α) in BV-2 and RAW264.7 cells with anti-inflammatory efficacy [2].

Paeonol significantly inhibits the production of IL-1β in BV-2 and RAW264.7 cells with anti-inflammatory efficacy [2].

Paeonol significantly inhibits the production of IL-6 in BV-2 and RAW264.7 cells with anti-inflammatory efficacy [2].

PCR® Supermolecule Paeonia Suffruticosa Root Extract inhibited the content of pro-inflammatory factors (IL-1β, IL-6, TNF-α) and inflammatory mediators (PGE2) by 72.06%, 79.84%, 54.54% and 91.14%, respectively, at a concentration of 0.25%.

Based on zebrafish testing, PCR® Supermolecule Paeonia Suffruticosa Root Extract has 97% neurological soothing efficacy at a concentration of 0.05%.

Based on zebrafish anti-inflammation testing, PCR® Supermolecule Paeonia Suffruticosa Root Extract has been shown to have 83% soothing effect on inflammation at a concentration of 0.05%.

• Anti-aging -Oxygen radical scavenging

From the figure, it can be seen that Paeonol has a significant scavenging effect on oxygen free radicals, and the strongest effect of Paeonol was found at a concentration of 20µM, which in turn indicates the anti-aging effect of Paeonol [3].

• Whitening

From the figure, it can be seen that the inhibitory effect of Paeonol on tyrosinase activity increases with increasing concentration of Paeonol, and the effect on the amount of melanin synthesis also increases with increasing concentration, thus confirming that Paeonol can achieve a reduction in melanin production by inhibiting tyrosinase activity [4].

As shown in the figure, compared with the blank control, the pigmentation of Paeonol-treated skin at the treated site was significantly suppressed, and the skin became significantly whiter. Thus, the topical application of Paeonol to the skin was confirmed to have whitening efficacy [5].

The upper figture shows the effect of natural products (two-week treatment) on pigmentation stimulated by two weeks of UVB irradiation of guinea pig skin. (A) Appearance of guinea pig skin; (B) Microscopic appearance of pigmented epidermis; (C) Microscopic appearance of dermal pigmentation; (D) HE staining images of stained skin sections (E) Fontana-Masson staining images of stained skin sections. I: Blank control; II: Paeonol treatment group

• Light color

PCR® Supermolecule Paeonia Suffruticosa Root Extract uses Supermolecule Capture Technology + Decolorization Technology to solve the problem of the dark color of Paeonia Suffruticosa Root Extract, so that its properties are white to off-white powder.

• Water soluble

Plamed solved the problem of insolubility of the active substance Paeonol in Paeonia Suffruticosa Root Extract by utilizing an original supramolecular capture technology to make it soluble in water.

• High stable

The PCR® Supermolecule Paeonia Suffruticosa Root Extract solutions with different PH (PH<9) were transparent and colorless after 1 year at low (4℃), normal (20~30℃) and high (45℃) temperatures without obvious discoloration.

• Technology

Plamed develops PMRelief® 9292 by supramolecular capture technology. The technology creatively integrates supramolecular embedding technology and molecular membrane filtration technology. It not only protects the active substance from acid, alkali, high temperature, sunlight and extraction chemical solvents. Also it  greatly ensures the naturalness and safety of the active substance. What’s more, it improves the bioavailability of the active substance and prolongs the duration of action.

• Human skin patch test

The safety test of 1.5% PCR® Supermolecule Paeonia Suffruticosa Root Extract was conducted according to the Technical Code for Cosmetic Safety (2015 edition), and the results showed that none of the 30 people had any adverse skin reactions 48h after using the sample.

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool and dry place and away from direct sunlight and oxidizing agents.