1. PMAnti-AGEs®100 Overview
Glycation reaction is also known as the Merad reaction, it is a natural part of human metabolism in which sugars (e.g., fructose, glucose, etc.) in the body react with proteins to produce glycation products. Glycation reaction is divided into two categories, namely enzymatic glycation reaction and non-enzymatic glycation reaction. Without enzymes, excess sugar in the body will also combine directly with proteins to produce late glycosylation end products, which can lead to dull skin and aging. The occurrence of glycation reaction is closely related to life activities, and the accumulation of glycation end-products can be aggravated by bad life habits and external factors. AGEs (Advanced glycosylation end-products) are one of the main culprits of skin dullness and aging.
PMAnti-AGEs®100 is a closed-loop anti-glycation ingredient from pre-prevention, process inhibition to damage reduction. Based on the test model, the anti-glycation efficacy is higher than the mainstream anti-glycation skincare products in the market. It’s composed of rhamnose, citrus paradisi (grapefruit) fruit extract, scutellaria baicalensis root extract and sophora japonica flower extract.
| Product name | PMAnti-AGEs®100 |
| Product ID | PMAA0101 |
| INCI name | RHAMNOSE, CITRUS PARADISI (GRAPEFRUIT) FRUIT EXTRACT, SCUTELLARIA BAICALENSIS ROOT EXTRACT, SOPHORA JAPONICA FLOWER EXTRACT, HYDROXYPROPYL CYCLODEXTRIN |
| Active ingredients content | Rhamnose≥5%, Naringin≥2%, Baicalin≥1%, Rutin≥4% |
| Solubility | Water soluble |
| Dosage recommended | 1%~3% |
| Application | Anti-glycation |
| Highlight★ | Multi-target 3D anti-glycation botanical ingredient |
3. Technical Data Sheet
| Items | Specification |
| Rhamnose | ≥5% HPLC |
| Naringin | ≥2% HPLC |
| Baicalin | ≥1% HPLC |
| Rutin | ≥4% HPLC |
| Bergapten | ≤5ppm HPLC |
| Organoleptic Tests | |
| Appearance | Powder |
| Color | Light yellow to yellowish brown |
| Odor | Characteristic |
| Physical Characteristics | |
| Moisture | ≤10.0% |
| Ash content | ≤7.0% |
| Heavy Metals | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microbiological Tests | |
| Total of bacteria | ≤1000cfu/g |
| Yeast & mold | ≤100cfu/g |
| Pseudomonas aeruginosa | Not detected |
| Staphylococcus aureus | Not detected |
| Heat-resistant escherichia coil | Not detected |
4. PMAnti-AGEs®100 Mechanism
The 3D anti-glycation ingredient, PMAnti-AGEs®100, is a synergistic combination of various plant active ingredients that provide a full range of anti-glycation effects from source inhibition, inhibition of intermediate active products, and reduction of all types of skin damage caused by glycation reactions.
1D-Anti-glycation at source: Blocks sugar and protein contact by competitively binding to reducing sugars and proteins.
2D-Inhibition of the glycation process: It can specifically inhibit and remove the intermediate active products of glycation reaction and further inhibit the production of AGEs.
3D-Reduce glycation damage: It can act on various adverse reactions such as inflammation, oxidation, and aging of the skin caused by glycation reactions.
5. PMAnti-AGEs®100 Efficacy Tests
- Biochemical anti-glycation test
In this test, PMAnti-AGEs®100 inhibited advanced glycosylation end products (AGEs) by 32.98%, 50.29%, 70.38% and 78.99% at 0.3%, 0.5%, 1% and 1.5% concentrations, respectively, which indicated that it had anti-glycosylation effects at all the above concentrations in a concentration-dependent manner.
- Anti-glycation test based on human dermal fibroblasts
Based on fibroblasts: PMAnti-AGEs®100 showed an anti-glycation efficacy of 29% and 31% at tested concentrations of 0.1% and 0.3%, respectively.
- Anti-glycation test based on human skin explant
Based on human-derived skin explant testing: PMAnti-AGEs®100 has an anti-glycation efficacy of 23% at a concentration of 3%.
- Comparison of the efficacy of PMAnti-AGEs®100 with mainstream anti-glycemic products on the market
The results of the biochemical anti-glycation test showed that the anti-glycation efficacy of PMAnti-AGEs®100 was higher than the three mainstream anti-glycation products in the market at 0.5%, 1% and 1.5% concentrations.
6. PMAnti-AGEs®100 Advantages
- Plant natural source
- 3D anti-glycation, which can have a significant inhibitory effect on the early, middle and late stages of AGEs production
- The anti-glycation efficacy of the biochemical method is higher than the mainstream anti-glycation products in the market in several concentration tests.
- High safety, backed by authoritative data
7. PMAnti-AGEs®100 Stability
PMAnti-AGEs®100 at different pH (4~8) was placed at low temperature (4℃), room temperature (20~30℃) and high temperature (45℃) for 2 weeks, the product had a very small amount of precipitation at pH 8, and there was almost no change in the color of the solution, which was stable; the rest of the group of solutions were almost unchanged and had good stability. Recommended application pH range 4-7, placed at room temperature or low temperature.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional multi-target 3D anti-glycation botanical ingredient PMAnti-AGEs®100 manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good multi-target 3D anti-glycation botanical ingredient PMAnti-AGEs®100 and good multi-target 3D anti-glycation botanical ingredient PMAnti-AGEs®100 price will help customers make good terminal products and help customers win a lasting and broad market.
