Ferulic Acid

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Ferulic Acid

Where to buy Ferulic Acid Powder with lowering Ferulic Acid price and high quality? Where to find good information of Wholesale Ferulic Acid and Purchase Ferulic Acid for sales? As the professional Ferulic Acid manufacturer, Plamed is your best choice.

Ferulic Acid (FA), also called 4-hydroxy-3-methoxycinnamicacid, is a cinnamic acid derivative. It is a kind of phenolic acid commonly found in many plants. Currently, Ferulic Acid mainly comes from natural plants and synthesis method. Plamed natural Ferulic Acid is extracted from rice bran. And we develop high purity Ferulic Acid of 99%. It is a natural cosmetic grade raw material. Plamed also produces synthetic Ferulic Acid with a good cost performance. Ferulic Acid has a variety of biological activities. It can scavenge free radicals, and promote the formation of enzymes that scavenge free radicals. It inhibits tyrosinase activity; it has good absorption ability of ultraviolet ray and trans-dermal absorption capacity. Therefore, Ferulic Acid has effect of whitening, anti-oxidation and sun protection. Cosmetics containing Ferulic Acid can improve skin dullness, as well as make skin delicate, shiny and full of elasticity. It is widely used in sun protection and whitening cosmetics.

Product Name	CAS Number	INCI Name
Ferulic Acid	1135-24-6	Ferulic Acid
Molecular Weight	Molecular Formula	Molecular Structure
194.19g/mol	C₁₀H₁₀O₄
Product ID	Specificcation	Minimal Package	Minimal Order Quantity
PMFS0301	Natural source 99% Synthesis 99%	1KG	1KG

Plamed develops natural Ferulic Acid and synthetic Ferulic Acid. Both of them are cosmetic grade raw materials, which can provide customers with different choice.

	Natural source	Chemical synthetic source
Raw material	Rice bran	Vanillin and malonic acid
Specific process	Hydrolyze oryzanol (alcohol extract of rice bran) by sodium hydroxide or potassium hydroxide under 90-100℃ for 8h, then add sulfuric acid to adjust pH value to acidity, Ferulic Acid is precipitated.	Use anhydrous pyridine as solvent and piperidine as catalyst, then obtain Ferulic Acid by condensation reaction.
Advantage	The product obtained by this method is Cis-Ferulic Acid with high purity. The process is simple; the raw material is easy to get; the comprehensive benefit is high.	Raw materials are readily available; less expensive than natural sources.
Disadvantage	/	Ferulic acid obtained by this method is a mixture of Cis-Ferulic Acid And Trans-Ferulic Acid. Reaction time is long (up to 3 weeks); large solvent consumption, and low yield.

Product Name	Specification
Ferulic Acid	Natural source 99% Synthesis 99%

Natural Ferulic Acid Specification

Items	Specifications
Assay	≥99% HPLC
Appearance	White or off-white color powder
Odor	Characteristic
Extract solvent	Water & ethanol
Physical Characteristics
Moisture	≤0.5%
Melting point	170.0℃~174.0℃
Natural degree c13 test	-33~36
Natural degree C14/12test	12-16
Solvent residue	Ethanol≤1000ppm

Synthetic Ferulic Acid Specification

Items	Specifications
Assay	≥99%
Appearance	White or yellowish needle-shaped crystal
Physical Characteristics
Melting point	172.0~175.0℃
Moisture	≤0.5%
Ash content	≤0.1%
Heavy Metals
Heavy metals	≤10ppm
Related impurities
Unspecified impurities	≤0.1%
Total impurities	≤0.5%

Anti-oxidation

Ferulic Acid, as a phenolic plant ingredient, can form relatively stable free radicals due to its conjugate system. Then it plays the role of stopping the free radical chain transfer in the automatic oxidation process of lipids. Therefore, Ferulic Acid has strong antioxidant activity, and can scavenge free radicals. Studies have shown that Ferulic Acid has a strong scavenging effect on DPPH free radicals, hydroxyl radicals and superoxide anions. Half inhibitory concentrations are 0.552mg /mL, 0.282mg /mL and 0.111mg /mL respectively. Ferulic Acid can also promote the production of free radical scavenging enzymes to achieve its anti-oxidative effect. It promotes the production of glutathione and NADP. When used in combination with vitamin C and vitamin E, it increases their stability and doubles their antioxidant capacity.

Whitening

Ferulic Acid can inhibit tyrosinase activity. It can reduce the proliferation activity of melanocytes. Test result shows that when use 0.1-0.5% Ferulic Acid solution, the number of melanocytes decreases from 117±23/mm² to 39±7/mm². The inhibition rate of tyrosinase is up to 86%, when use 5mmol/L Ferulic Acid solution. Therefore, Ferulic Acid can whiten skin and remove spots. It has great whitening effect.

Sun protection

Ferulic Acid has good sun protection function. It can effectively absorb the ultraviolet rays in the wavelength range of 290~330nm. Thereby it prevents or reduces skin damage caused by the ultraviolet rays. (The UV rays in the range of 305-310nm are most likely to induce the skin erythema).

Pharmacological studies of Ferulic Acid and cosmetics

Test Item	Concentration	Result
Elimination of free radical DPPH		Half elimination quantity EC₅₀: 0.226mg/mL
Elimination of superoxide free radicals		Half elimination quantity EC₅₀: 0.530 mg/mL
Elimination of hydroxyl radicals		Half elimination quantity EC₅₀: 0.283mg/mL
Inhibition of lipid peroxidation	12.5mmol/L	Inhibition rate: 67.8%
Promotion of collagen production by culture of human dermal fibroblasts	0.08%	Promotion rate: 716.7（blank 100）
Promotion of keratinocytes proliferation by cell culture	10ug/mL	Promotion rate: 234（blank 100）
Inhibition of tyrosinase activity	0.5mmol/L	Inhibition rate: 53.9%
Inhibition of cyclooxygenase-2 activity		Half inhibition quantity IC50: 10umol/L
Inhibition of interleukin -4 production	4umol/L	Inhibition rate: 18.2%
Inhibition of mast cell activity	4umol/L	Inhibition rate: 14.5%

Plamed Ferulic Acid has wide sources and price advantage;
Good solubility; and the solution is clear and transparent.

Ferulic Acid contains a highly conjugated system. It can strongly absorb the ultraviolet rays of 290-350nm. 0.7% Ferulic Acid can effectively prevent skin erythema caused by UVB. It is an effective light stabilizer. It can resist light toxicity, and is widely used in sunscreen products.
Ferulic Acid has a broad spectrum of anti-oxidative property, and also has skin whitening effect. It can be used in whitening and anti-aging cosmetics.

Product	Reference Dosage
Ferulic Acid 99%	0.3%-2.0%

Attention:

Ferulic Acid has good stability in buffer solution with pH 2.62-5.10. As the environment becomes more alkaline, Ferulic Acid is also degraded and deactivated. Therefore, when making cosmetics containing Ferulic Acid, pH value should be controlled in the above range.
Ferulic Acid has poor photo-stability. When exposed to light, it is easy to be decomposed. It should be kept away from light.

Ferulic Acid application cases in major cosmetic brands in the world:

Country	Brand	Product
China	Chando	Cellcrystal Whitening Emulsion, Crystal White Deeply Essence, Aging Resistance White Spot Corrector, Snow Whitening Lotion
China	Genuine Namir	Snow Rose Crystal Whitening Essence
Korea	Su:m 37º	Secret Essence, Bright award Micro Whipping Deep Cleansing Foam
USA	Elizabeth Arden	Prevage City Smart Spf50 Hydrating Shield, Mad Hippie Hydrating Nutrient Mist, Prevage Anti-Aging Antioxidant Infusion Essence
	KIEHL‘S CILANTRO	Orange Extract Pollutant Defending Masque
	Estee Lauder	Re-Nutriv Re-Creation Night Creme
France	LA ROCHE-POSAY	Sensi White Eye Cream, Pigmentclar Serum
France	Lancome	Advanced Genifique

Whitening emulsion：

Ingredient	Content（%）	Ingredient	Content（%）
Ferulic Acid	0.5	BHT	0.01
Monoglyceride	10.0	Butylparaben	0.1
Liquid paraffin	10.0	Propylene glycol	10.0
Mineral oil	4.0	Polyoxyethylene 20 cetyl ether	2
Cetyl alcohol	5.0	γ- tocopherol	0.05
Refined water	Add to 100

Skin care gel:

Ingredient	Content（%）	Ingredient	Content（%）
Ferulic Acid	0.5	Lecithin	6.0
Shea butter	3.0	Chrysin	0.1
Vitamin A palmitate	0.2	Vitamin H	0.08
Sodium citrate	0.5	Glycerin	0.2
Carbamide	0.2	Sodium dichloroacetate	0.5
Hydrolyzed collagen	2.0	Xanthan gum	1.4
Sorbitol	3.0	Preservative	Appropriate
Refined water	Add to 100

Skin care emulsion:

Ingredient	Content（%）	Ingredient	Content（%）
Ferulic Acid	0.25	Liquid paraffin	20.0
Paraffin	4.0	Glucose sesquistearate	2.0
Aluminium stearate	0.4	Naringin	1.0
Vitamin E acetate	2.0	Ascorbyl Palmitate	0.1
Glycerin	5.0	Preservative	Appropriate
Refined water	Add to 100

Skin care cream:

Ingredient	Content（%）	Ingredient	Content（%）
Ferulic Acid	1.0	Squalane	10
Isopropyl myristate	7.0	Docosanol	1.0
Cetyl alcohol	5.5	Glycerin monostearate	2.0
D-α- tocopherol	0.05	POE(20) Sorbitan monostearate	2.0
Xanthan gum	0.1	1,3 butanedio	2.0
Glycerin	3.0	Sorbitol	5.0
Activator	0.2	Ph regulator	Appropriate
Refined water	Add to 100

Shampoo：

Ingredient	Content（%）	Ingredient	Content（%）
Ferulic Acid	1.5	Triethanolamine	3.5
Propylene glycol	15.0	Menthol	0.1
Ethanol	15.0	Polyoxyethylene hydrogenated castor oil	0.5
NSAIDs	1.0	Fragrance	0.3
Refined water	65.1

Ferulic Acid Safety

Ferulic Acid is included in The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014. No reports show its insecurity.
Cosmetic, Toiletry &Fragrance Association (CTFA) and European Union (EU) has specified Ferulic Acid as a cosmetics ingredient.
Ferulic Acid has also be added to cosmetics as a sunscreen in Japan.