Glutathione

Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.

Glutathione

Glutathione has a good water-solubility, and it is easy to prepare cosmetics;
The extraction process is safe and effective, without residual pollutants.

Where to buy Glutathione Powder with lowering Glutathione price and high quality? Where to find good information of Wholesale Glutathione and Purchase Glutathione for sales? As the professional Glutathione manufacturer, Plamed is your best choice.

Glutathione (GSH), also named Reduced Glutathione, is a tripeptide composed of glutamate, cysteine, and glycine. It can be found in almost every cell of human body. Nowadays, the industrial production of Glutathione is mainly obtained by enzymatic synthesis. In the method, Glutathione has a high purity and good water-solubility. As an active tripeptide with important physiological functions, Glutathione is the most important non-protein sulfhydryl compound in organisms. It has biological activities such as detoxification, anti-oxidation, free radical scavenging, skin-whitening and spot-fading. Therefore, it is widely used in cosmetics, medicine, health care products and other industries. It can be soluble in water greatly and easy to be added into all kinds of skin-whitening cosmetics. Plamed Glutathione is divided into cosmetics grade and medical grade.

Product Name	CAS Number	INCI Name
Glutathione	70-18-8	Glutathione
Molecular Weight	Molecular Formula	Molecular Structure
307.32g/mol	C₁₀H₁₇N₃O₆S
Product ID	Specificcation	Minimal Package	Minimal Order Quantity
PMB1603	98%	1KG	1KG

There are four main methods of preparing Glutathione: enzymatic synthesis, solvent extraction, chemical synthesis and fermentation. Plamed produces Glutathione by enzymatic synthesis. And the product is of high purity and less pollution to environment. It has a good performance-price ratio.

Method	Raw material	Operation	Purity	Pollution
Enzymatic synthesis	Use L-glutamic acid, L-cysteine and glycine as substrate, and use the natural glutathione synthetase of organisms, then add a little ATP/ADP to synthesize Glutathione	Fast reaction speed, high sensitivity, clear process, but high cost.	High	Low
Solvent extraction	Use wheat germ and yeast as raw materials, and then separate and purify to produce Glutathione.	Backward technology, small production scale, low output, low cost.	Higher than that of enzymatic synthesis.	Low
Chemical synthesis	Use glutamic acid, cysteine and glycine as raw materials to synthesize Glutathione	Many reaction steps, long reaction time, complex operation and high cost.	Low	Severe
Fermentation	Use cheap carbohydrates as raw materials, then convert the materials into glutathione by the metabolism of substances in specific microorganisms	Mild reaction conditions, fast production speed, low cost.	Not high	Low

Reduced Glutathione VS Glutathione Disulfide

	Reduced Glutathione (GSH)	Glutathione Disulfide (GSSG)
State	Active state	Inactive state
Percentage of glutathione	More than 95%	1% or so
Function	Free radical scavenging, anti-aging, skin-whitening	/
Application	Whitening and antioxidant cosmetics	/
Relation	Reduced Glutathione can convert into GSSG. GSSG’s physiological activity is very low and has little effect, because it accounts for a small proportion. So Glutathione is usually called Reduced Glutathione, and it plays a main role.

Product Name	Specification	Color
Glutathione	98% HPLC	White powder

Items	Specifications
Assay	≥98% HPLC
Appearance	White or off-white powder
Related substances	GSSG≤1.5%
Chlorides	≤200ppm
Sulfates	≤200ppm
Ammonium	≤200ppm
Physical Characteristics
Loss on drying	≤0.5%
Residue on ignition	≤0.1%
Specific rotation	-15.5°～-17.5°
Heavy Metals
Heavy metals	≤10ppm
Iron	≤10ppm

Whiten skin and remove freckle

Glutathione can chelate internal and external toxins such as heavy metals. It can prevent skin pigmentation. Also it can inhibit the formation of new melanin and reduce its oxidation. Glutathione alleviates skin problems such as chloasma. It has a great function of lightening skin and removing freckles. Meanwhile, Glutathione is small molecular peptide. So it can easily penetrate cell membrane and be absorbed by the skin, when applied externally. It is an effective cosmetic ingredient for whitening skin

Anti-oxidation

Glutathione’s structure contains a lively thiol group-SH. So it is easily oxidized and dehydrogenated. The free radicals can be reduced directly into acidic substances by combining the thiol group with free radicals in the body. Thereby it accelerates the elimination of the free radicals; and fight against free radical damage to the skin. At the same time, Glutathione is a kind of radiation protective agent. It can enable radiation to produce highly active free radicals in living organisms through direct and indirect action. And then Glutathione can clear away these free radicals to achieve its anti-oxidant effect.

Isolate PM2.5

Glutathione can isolate the damage of PM2.5 to the skin, when acting on the skin surface.

Test Items	Concentration	Result
Elimination of free radical DPPH	0.1%	Elimination rate：65%
Removal rate of superoxide radical	1.0%	Elimination rate：23.1%
Inhibition of lipid peroxidation	0.1%	Inhibition rate：40%
Inhibition of protein damage under UVA	1mmol/l	Inhibition rate：79.7%
Inhibition of hyaluronic acid decrease	1%	Inhibition rate：57.4%
Inhibition of the activity of B-16 melanocytes	0.1mg/ml	Inhibition rate：57.1%
Inhibition of tyrosinase activity	0.1mg/ml	Inhibition rate：83.5%

Glutathione is mainly used in whitening skin care products, such as serum, facial mask, emulsion, toner, essence, cream, etc.

Product	Reference Dosage
Glutathione 98%	0.1-0.5%

Attention:

Glutathione cannot be used with vitamin B₁₂, orotic acid (vitamin B₁₃) into cosmetics, or it will cause skin irritation.

Glutathione application cases in major cosmetic brands in the world:

Country	Brand	Product
Korea	Cindella	Cindeltox white cream
	Secret key	Snow White Cream
	Dr. Althea	Power Whitening Glutathione Cream
	Claires	Guerisson 9 Complex, Essence
	G9skin	White In Milk Whipping Foam, cream , eye cream，sun, serum
	Wishtrend	Hours-Long Moisturizing Gauze Sheet Mask
	Papa Recipe	Bombee Whitening Honey Mask Pack
	Klavuu	Marine Collagen Micro Cleansing Water
USA	Relumins	Glutathione toner, essence, body whitening cream
	Kirkman	Reduced L-Glutathione Lotion
	Swanson	L-Glutathione Cream with Setria
	BeShiny	Glutathione Skin Whitening Brightening Serum
Thailand	Mistine	Intensive Whitening Facial Cream, utathione Intensive Whitening Serum
	Shouvy	Whitening Body Lotion, ening Bleaching Soap
	Cathy Doll Karmart	L-glutathione Magic sunscreen
France	ATrue	Watery Calming Cream

Whitening Toner:

Ingredient	Content (Mass)	Ingredient	Content (Mass)
Glutathione	54	Aloe Vera Extract	54
Papaya extract	50	Sesame oil	54
Paeoniflorin	50	Shea butter	54
Tetrahydrocurcumin	50	Vitamin C	56
Black bean estroge	50	Blackberrglily Rhizome Extract	54
Lubrajel oil	50	Ophiopogonis japonicus P.E	50
D- panthenol	50	1,2- octylene glycol	54
Guar gum	52	Nigella damascena extract	54
Cocoa butter	54	Sorbitan octanoate	50
Codium tomentosum extract	50	Water	2000

Anti-spot Lotion:

Ingredient	Content（%）	Ingredient	Content（%）
Glutathione	0.5	Phosphoric acid cetyl ester diethanolamine	2.0
EGMS	12.0	Catechol	2.0
Isopropyl palmitate	12.0	Ascorbyl palmitate	0.2
2- 16/18 glycol	2.0	Acetic acid	0.2
Vaseline	2.5	Methoxycinnamate	1.0
Lanonol	3.0	Butyl methoxydibenzoyl methane	1.0
Propylparaben	0.1	2-methyl5-chloroisothiazolone	0.05
BHA	0.2	Imidazolidinyl urea	0.1
BHT	0.3	Parsol 1789	1.0
Cysteine	0.5	Fragrance	0.6
Refined water	Add to 100

Glutathione Safety

CTFA has recognized Glutathione as a raw material for cosmetics;
The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014 both include Glutathione. There are no reports indicating that Glutathione is unsafe for external use.

Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.