Kojic Acid Dipalmitate

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Kojic Acid Dipalmitate

1. Good stability in heat and light; no color change.
2. Good oil solubility.

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Kojic Acid Dipalmitate (KAD) is a liposoluble derivative of kojic acid. It’s also called 2- palmitoyl methyl -5- palmitoyl – pyranone. It has a greater ability to inhibit melanin formation than kojic acid. There is no hydroxyl group in its molecular structure, so it won’t form hydrogen bond with other active ingredients in cosmetics to affect their functions, and it has a good compatibility. As a whitening agent, KAD is widely used in cosmetics industry.

Product Name	CAS Number	INCI Name
Kojic Acid Dipalmitate	79725-98-7	Kojic Acid Dipalmitate
Molecular Weight	Molecular Formula	Molecular Structure
C₃₈H₆₆O₆	618.93g/mol
Product ID	Specificcation	Minimal Package	Minimal Order Quantity
PMB0801	98%	1KG	1KG

Kojic Acid Vs Kojic Acid Dipalmitate

	Function	Mechanism	Easy to make formula	Stability	Stimulate	Effect	Safety	Price
Kojic Acid	Skin whitening, anti-bacterial	Tyrosinase inhibitor	++	++++	+	++++	++++	++
Kojic Acid Dipalmitate	Skin whitening, moisture	Tyrosinase inhibitor	+++++	+++++	–	+++++	+++++	+++

Kojic acid is a colorless, odorless, safe and effective tyrosinase inhibitor produced by fermentation. It exists in many brewing foods, including soy sauce, soybean, wine, and so on. The microorganisms that can produce kojic acid are aspergillus parasiticus, aspergillus oryzae , aspergillus flavus, etc. Japan began kojic acid production in the 1970s. Kojic acid is mainly applied in cosmetics and health care products; also it can be used as a natural preservative in the food industry.

Items	Specifications
Assay	Kojic Acid Dipalmitate≥98%
Appearance	White sheet crystal powder
Melting point	92-96℃
Loss on Drying	≤0.5%
Residue on ignition	≤0.5%
Color reaction of ferric chloride	Negative
Heavy Metal
Total Heavy Metals	≤10ppm
As	≤2ppm
Microbiological Tests
Total Plate Count	≤300cfu/g
Total Yeast & Mold	≤100cfu/g

Skin-whitening

Kojic Acid Dipalmitate can effectively restrain the activity of tyrosinase. It can repair skin problems, including chloasma, age spots, pigmentation, etc. Moreover, it has effect of sun block and skin-lightening. KAD possesses a good skin-whitening function.

Application	Product	Reference Dosage
Cosmetics	Mask, essence, cream, moisturizer	1% -3%

Kojic Acid Dipalmitate application cases in cosmetics brand around the world:

Country	Brand	Product	Main ingredient
USA	Petal Fresh	Anti-Wrinkle Cream	Aqua (Water), Glycerin, Cetyl Alcohol, Stearyl Alcohol, Stearic Acid, Kojic Dipalmitate, Rubus Idaeus Fruit Extract, Punica Granatum Extract, Persea Gratissima Oil, Aloe Vera Leaf Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract, Rosa Canina Fruit Extract, Vaccinium Myrtillus Fruit/Leaf Extract, Saccharum Officinarum Extract, Citrus Aurantium Dulcis Fruit Extract, Citrus Medica Limonum Fruit Extract, Collagen, Vitamin A, Dehydroacetic Acid, Benzyl Alcohol, Fragrance
	Palmer’s	Dark Spot Corrector and Fade Serum	Kojic Dipalmitate, Hydroquinone, Retinol, Alpha Hydroxy Fruit Acids, Vitamin C, Vitamin E, Bilberry Extract, Shea Butter
	DeVita	Skin Brightening Serum	Aloe Barbadensis, Magnesium Ascorbyl Phosphate, Capric/Caprylic Triglycerides, Olea Europaea Oil, Panthenol, Phyllanthus Emblica Fruit Extract, Kojic Dipalmitate, Arbutin, Persea Gratissima Oil, Centella Asiatica, Tocopherol, Nicotinate, Bearberry Leaf Extract, Citrus Paradisi Seed Extract, Thymus Vulgaris Essential Oil, Potassium Sorbate.

Anti-freckle and whitening mask:

Ingredient	Content（%）	Ingredient	Content（%）
Kojic Acid Dipalmitate	0.3	Silk protein	3.0
Ethanol	3.0	Polyacrylic acid	1.0
Methylparaben	0.1	Propolis	3.0
Squalane	2.0	Propylene glycol	5.0
Zinc Oxide	10.0	Kaolin	10.0
Fragrance	Appropriate amount

Whitening toner:

Ingredient	Content（%）	Ingredient	Content（%）
Kojic Acid Dipalmitate	0.15	Oleyl alcohol polyglycol ether	2.0
Fragrance	Appropriate amount	Preservative	Appropriate amount
Potassium hydroxide	0.03	Polyethylene glycol	2.0
Placenta fluid	8.0	Purified water	Add to 100
Glycerin	5.0	Ethanol	10.0

Anti-aging moisturizing cream：

	Ingredient	Content（%）	Ingredient		Content（%）
Group A	Atractylodes	5-10	Poria Locos		5-10
	Ampelopsis japonica	5-10	Angelica dahurica		5-10
	Common bletilla pseudobulb	5-10
Group B	Glycerin	3-8	Camellia Sinensis		1-3
	Vitamin A	1-2	SOD		0.3-0.7
	Kojic acid dipalmitate	0.5-2
	Vaseline	20-40	Distilled water	10-15
	Water	75-250

Preparation method:

Take Group A ingredients, smash and mix them well, then get mixture 1; Pour mixture 1 into water for 1 to 3 hours( ratio is 1：3), filtrate, and boil the filtration again, then filtrate again and get the filtration 2. Concentrate the filtration 2, then get filtration 3; add distilled water into Group B ingredients and heat to obtain mixture 4; heat vaseline until melting, then add filtration 3 and mixture 4, stir well and cool it, then get the cream.

On the Announcement of Name List of Cosmetics Raw Material published by China Food and Drug Administration in 2014, and The Catalog Of the International Cosmetics Raw Material Standard English Name issued by CTFA ，EU and CAFFCI in 2010 both have recognized Kojic Acid Dipalmitate as a raw material of cosmetics. There is no reports showing its insecurity for external use. Kojic Acid Dipalmitate has a higher stability than Vitamin-C, so it is efficient and has no side effects.

Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place away from direct sunlight and oxidizing agents.

1. Kojic Dipalmitate Introduction

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.