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Glabridin, also known as Glycyrrhizic Flavone, is an kind of isoflavone. It is extracted from the dried rhizome of Glycyrrhiza glabra L. Glabridin is one of the main flavonoids in Glycyrrhiza glabra (accounting for 11%). Plamed develops 2 different specifications of Glabridin: 90% white powder, 40% white powder. Numerous studies have shown that Glabridin can effectively inhibit the activity of various enzymes during melanin production, especially inhibiting tyrosinase activity. Moreover, it has other skin-care effect such as anti-inflammation, anti-oxidation and sun-protection. It is a safe, mild and effective whitening active ingredient. Only 100g Glabridin can be extracted from 1000kg Glycyrrhiza glabra. Because of its complicated extraction process, high cost and price, it is comparable to gold price. Therefore, it is known as “Whitening Gold” in the world cosmetics industry. Glabridin has attracted much attention and is widely used in skin beauty products and cosmetics.
| Product Name | CAS Number | INCI Name | |
| PMWhite® Glabridin | 59870-68-7 | GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| C20H20O4 | 324.37g/mol |  |
|
| Product ID | Specification | Minimal Package | Minimal Order Quantity |
| PMWT0101 | 40% White powder | 100g | 100g |
| PMWT0102 | 90% | ||
Glycyrrhiza glabra (Latin name: Radix Glycyrrhizae Glabrae) is a perennial herb of the Leguminosae family. It is also named licorice. It has thick roots and stems. Glycyrrhiza glabra mainly grow in ditch, roadside, river bank terraces and even arid saline soil. In China, the main producing areas of Glycyrrhiza glabra L. are Xinjiang and the northeastern provinces. Among them, Xinjiang is rich in licorice resources and good in quality, mainly distributing in Korla, Aksu and Shihezi areas; and there are both wild and artificial cultivation resources. Europe, the Mediterranean countries, Russia, Siberia and Mongolia also have licorice distribution. The roots and stems of Glycyrrhiza glabra are available for medicinal purposes. And its dried roots are mainly used in cosmetics.
40% Glabridin Manufacturer COA
| Items | Specifications |
| Assay | 40% |
| Physical Characteristics | |
| Apperance | White powder |
| Loss on drying | ≤5.00% |
| Residue on ignition | ≤2.00% |
| Heavy Metals | |
| Heavy metals | ≤20ppm |
| As | ≤2ppm |
| Microbiological Tests | |
| Total plate count | ≤1000cfu/g |
| Yeast & mold | ≤100cfu/g |
| Escherichia coli | Not detected |
| Salmonella | Not detected |
90% Glabridin Manufacturer COA
| Items | Specifications |
| Assay | 90% |
| Physical Characteristics | |
| Appearance | White powder |
| Loss on drying | ≤5.00% |
| Residue on ignition | ≤2.00% |
| Heavy Metals | |
| Heavy metals | ≤20ppm |
| As | ≤2ppm |
| Microbiological Tests | |
| Total plate count | ≤1000cfu/g |
| Yeast & mold | ≤100cfu/g |
| Escherichia coli | Not detected |
| Salmonella | Not detected |
As a natural whitening ingredient, the skin-whitening mechanism of Glabridin mainly includes: (1) inhibiting tyrosinase activity; (2) inhibiting the activity of dopachrome tautomerase (TRP-2) (3) inhibiting the activity of DHICA oxidase; (4) exerting the function of endothelin antagonist; (5) increasing the total antioxidant capacity of the skin; (6) effectively scavenging oxygen free radicals and its chain reaction. Moreover, through these synergistic effects, it effectively prevents the polymerization of 5,6-dihydroxyindole (DHI) and the production of dopachrome. Thereby Glabridin can disturb and hinder the formation and transport of melanin; and then it inhibits and reduces pigmentation so as to achieve whitening skin effect.
The anti-inflammatory effect of Glabridin is related to its anti-oxidative activity of scavenging reactive oxygen. Glabridin can inhibit the production of NO in macrophages and the expression of inducible NO synthase. Then it can prevent the development of inflammation. Also Glabridin can inhibit the activity of staphylococcus aureus and candida albicans. It has a strong antibacterial effect, and can be used for the treatment of acne.
Glabridin has shown strong anti-free radical oxidation in the cytochrome oxidation system. It can significantly inhibit the free radicals generated in the body’s metabolism. Then it prevents the oxidation-sensitive bio-macromolecules (LDL, LDL, DNA) and cell walls from being oxidized and damaged by free radicals. As an antioxidant, Glabridin can also inhibit the production of reactive oxygen species and activation of p53; it regulates the cleavage of BCL-2 and poly ADP ribose polymerase. And it can fight against oxygenated DNA fragments of keratinocytes induced by UV; then it prevents sun-induced skin aging.
The conjugate property in the molecular structure of licorice flavonoids assures that Glabridin is characterized by strong absorption of both ultraviolet and visible light. Therefore, the sunscreen mechanism of Glabridin has the highest absorption peak for ultraviolet rays. And it effectively blocks ultraviolet rays from the skin surface after being applied to the skin. Furthermore, it also works by absorbing unstable molecules of high-energy ultraviolet rays. Then it converts the ultraviolet rays that damage the skin into harmless, low-energy and non-damaging ones.
PMWhite® Glabridin is mainly used in whitening and freckle-removing cosmetics, such as emulsion, toner, essence, facial mask, cream, etc.
| Application | Reference Dosage |
| Whitening and lightening | 0.001-0.1% |
| Sun block and anti-spot | 0.0007-0.05% |
| Treatment for acne and prevention for hair loss | 0.01-0.5% |
Attention: The reference dosage of PMWhite® Glabridin is based on pure active.
PMWhite® Glabridin application examples in major cosmetic brands around the world:
| Country | Brand | Product |
| China | Grain Rain | Glabridin brightening essence, beauty cream, repair pure essence, night cream |
| LUCENBASE | Energizing repair cleanser, lotion, toner, cream, essence | |
| Switzerland | Valmont | Night white essence |
| France | Helena Rubinstein | Life pearl cellular |
| Chanel | Sublimage | |
| USA | Estée Lauder | Re-nutriv radiant white age renewal cream |
| Arbuderm | Strength bleaching cream | |
| MDSUN | Super brightening mask | |
| Korea | Atomy | Spot-out essence |
| Australia | Organic Nation | Skintone serum |
Whitening lotion：
| Ingredient | Content（%） | Ingredient | Content（%） | |
| Phase A | PMWhite® Glabridin | 0.02 | MSH | 5.0 |
| Water | 2..0 | Propylene glycol | 7.0 | |
| Phase B | Dc5225c | 5.0 | Dc345 | 10.0 |
| Dc200 | 5.0 | |||
| Phase C | Water | Add to100 | M-68 | 2.0 |
| Azone | 0.5 | SIMULGEL EG | 2.0 | |
| Glycerin | 5.0 | Hyaluronic acid | 0.1 | |
| Fragrance | Appropriate amount | Preservative | Appropriate amount | |
(DC5225C is used as W/O emulsifier; propylene glycol improves the stability of the product and plays a moisturizing role; M-68 acts as an O/W liquid crystal emulsifier to help the product form a liquid crystal structure; azone is used as a penetration enhancer to promote skin absorption of whitening ingredients; glycerin, hyaluronic acid act as a humectant to increase skin moisture; SIMULGEL EG acts as a viscosity modifier. At the same time, MSH and Glabridin are used as whitening active agents.)
Preparation method:
Whitening cream：
| Ingredient | Content（%） | Ingredient | Content（%） |
| PMWhite® Glabridin | 0.1 | Magnesium aluminosilicate | 0.5 |
| Xanthan gum | 0.5 | Hexadecanol | 1.0 |
| Stearin | 4.0 | Glycolic acid | 5.0 |
| Hydrogenated polyisobutene | 4.0 | Ammonium hydroxide | Ph value 4 |
| Preservative | 0.5 | Refined water | Add to 100 |
Whitening night cream：
| Ingredient | Content（%） | Ingredient | Content（%） |
| PMWhite® Glabridin | 0.003 | Glycerin | 5.0 |
| Stearic acid | 15.0 | Propylene glycol | 3.0 |
| Cetanol | 1.0 | Refined water | Add to 100 |
| Potassium hydroxide | 0.7 | ||
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
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