Technology Platforms Driving Ingredient Innovation
Plamed | Combining advanced formulation science, molecular engineering, and biotechnology to develop high-performance functional ingredient solutions.
Discovery Date: June 2026
Rethinking Skin Aging:
Plamed’s Perspective on Anti-Aging
When people talk about anti-aging, the first things that often come to mind are collagen, antioxidants, or wrinkle reduction. However, wrinkles are merely the visible outcome of aging, not the aging process itself. Driven by advancements in dermatological science, we have come to realize that skin aging is not triggered by a single factor. Rather, it is a highly complex process involving neural regulation, structural support degradation, oxidative damage, and shifts in cellular viability.
Different signs of aging correspond to distinct biological mechanisms. Therefore, a truly effective anti-aging strategy should not be limited to a single ingredient or a solitary efficacy metric. Instead, it must establish systemic solutions tailored to different aging pathways.
Based on this understanding and rooted in the key mechanisms of skin aging, Plamed has built a multi-dimensional anti-aging solution framework. This system revolves around four core directions: Neural Dynamic Aging, Structural Aging, Oxidative & Glycation Aging, and Cell Lifespan & Regenerative Potential. Through the innovative development of active ingredients, we deliver scientifically advanced and comprehensive anti-aging support.
- Neural Dynamic Aging
- Structural Aging
- Oxidative & Glycation Aging
- Cell Lifespan & Regenerative Potential
1. Neural Dynamic Aging
Understanding how expression lines transition into permanent wrinkles
Expression lines do not appear overnight; they are driven by continuous neural signals causing repetitive muscle contractions. Over time, these dynamic expression lines gradually transition into permanent, visible wrinkles. Gaining deep insights into this dynamic neuromuscular interplay allows for early-stage intervention in visible aging signs.
2. Structural Aging
Maintaining ECM homeostasis and skin structural support
Collagen is only one component of the skin’s architecture. What truly dictates skin firmness and anti-wrinkle is the extracellular matrix (ECM) ecological network, co-established by collagen, elastin, hyaluronic acid, and the dermal-epidermal junction (DEJ). As we age, this intricate network gradually loses its equilibrium, leading to a decline in structural support, followed by the appearance of wrinkles and sagging. Consequently, helping maintain ECM homeostasis serves as a vital foundation for sustaining long-term skin youthfulness.
3. Oxidative & Glycation Aging
Countering invisible aging damage
UV radiation, environmental pollution, psychological stress, and glycation reactions consistently compromise skin structure and function. While oxidation and glycation do not generate wrinkles instantly, they relentlessly weaken the skin’s intrinsic capacity to maintain its youthful state. Therefore, they are recognized as critical drivers influencing the long-term aging trajectory.
4. Cell Lifespan & Regenerative Potential
Supporting long-term healthy skin performance
A growing body of research focuses on mitochondrial function, cellular energy metabolism, and long-term cell viability. These intrinsic factors dictate the skin’s adaptability when facing chronological and environmental challenges, directly impacting the maintenance of its long-term health. In the future, the competitive anti-aging solution lies not just in improving wrinkles, but in helping the skin preserve its long-term stability and vital energy.
5. Plamed’s Vision
Transitioning from raw materials to comprehensive solutions
At Plamed, we believe that skin aging is not driven by a single isolated pathway. Neural dynamic shifts, structural support degradation, oxidative and glycation stresses, along with the decline in long-term cellular viability, collectively shape the process of skin aging. Therefore, we look beyond single efficacy indicators, focusing instead on the complement and synergy between different aging mechanisms.
Through continuous mechanistic research, rigorous efficacy verification, and meticulous botanical/active materials screening, Plamed is dedicated to helping you build scientifically backed, complete, and highly market-competitive anti-aging solutions.
Discovery Date: June 2026
Beyond the Single Target of TRPV1:
Plamed's AP Technology Comprehensively Addresses TRPV Family Stimulus Responses
With the deep application of neuroscience in skin research, TRPV1 has gradually become one of the most prominent research targets in the anti-irritation field, steering the industry further from traditional anti-inflammation and barrier repair research toward neuro-anti-irritation research.
However, skin irritation perception is not engaged by TRPV1 alone. Multiple sensory receptors, such as in vivo tests, are also involved in identifying and transmitting different types of irritation signals. When other receptors are activated, regulating a single receptor alone cannot fully cover the complex process of skin irritation perception.
Based on this understanding, Plamed took the lead in introducing Action Potential (AP)—the common convergence point of skin irritation signals, into cosmetic anti-irritation research, and established the AP neural anti-irritation pathway research system. Carrying out systematic explorations around mechanism research, efficacy validation, and industrial application, it provides a new scientific perspective for anti-irritation research.
- Shifting from Single-Receptor Targeting to Neural Signal Common Pathway Regulation
- Constructing and Validating the AP Neuro-Anti-Irritation Research System
- Jointly Releasing the Industry's First "White Paper on Cosmetic Action Potential (AP) Neuro-Anti-Irritation Pathway"
- Driving the Industrial Application of Neuro-Anti-Irritation
1. Unlocking the Fundamental Source of Stimulus Perception
Traditional anti-irritation research has long been confined to single receptor targets like TRPV1, failing to cover complex and diverse skin irritation pathways. Plamed discovered that all irritation signals mediated by the full TRP receptor family must ultimately pass through the core node of Action Potential (AP) to be transmitted from the peripheral skin to the central nervous system. Targeting this universal hub allows for simultaneous management of burning (heat), stinging (pain), itching, and redness triggered by various factors, achieving true broad-spectrum anti-irritation.
2. Constructing the AP Neuro-Anti-Irritation Foundational Framework
Plamed discovered for the first time that Kava root extract possesses potent AP regulatory activity. Centered around mechanism research, it completed scientific substantiation from laboratories to human clinical trials alongside industrial application, forming a complete research framework.
3. Jointly Releasing the White Paper on Cosmetic Action Potential (AP) Neural Anti-Irritation Pathway
The White Paper systematically elucidates the core mechanism of AP-mediated stimulus transmission, comparatively analyzes the pros and cons of traditional anti-irritation targets, and establishes a complete scientific system for raw material R&D and efficacy evaluation.
4. Anti-Irritation Raw Material Solutions
PMSoothe® Kava97 is the core industrial outcome for Plamed on AP pathway research. It simultaneously acts on both the receiving and transmitting ends of stimulus signals, achieving dual-pathway regulation from neural perception to irritation relief. The industrial transformation of relevant technical achievements has been completed.
Discovery Date: June 2026
New Repair Active and Its Synergistic Application Value with the Classic Centella Asiatica Extract
Skin repair is one of the fundamental research directions in skincare R&D. Classic repair actives such as Centella Asiatica extract and madecassoside, through long-term research and market validation, have become an important foundation for repair product development.
Building upon this, Plamed continues to focus on a more fundamental question: Are there other unexplored ingredients that possess valuable skin-repairing activity? And can these ingredients establish a practical, applicable relationship with classic systems?
- First globally to conduct research on the repair value of Kava Pepper Root Extract
- Joint application study of the new repair ingredient and classic systems
- Application performance of the classic Centella Asiatica Extract
1. First globally to conduct research on the repair value of Kava Pepper Root Extract
Cell and organismal model studies indicate that PMSoothe® Kava97 exhibits excellent repair potential, with performance close to that of classic Centella Asiatica actives. Plamed believes that Kava Pepper Root Extract holds further research and application value in the skin repair field.
2. Joint application study of the new repair ingredient and classic systems
In a 3D skin model, the joint application of PMSoothe® Kava97 and madecassoside outperformed their individual applications. Research results show that a well-conceived combination of actives can not only enhance repair performance but also provide more design space for product development.
3. Application performance of the classic Centella Asiatica Extract
Total triterpenes of Centella Asiatica also exhibit excellent repair performance. For product development, the value of a raw material does not solely depend on purity itself; scientifically selecting the suitable active ingredient is equally vital.
4. Plamed’s Perspective
Plamed focuses not only on the discovery of new repair ingredients but also on their synergistic application value when paired with classic repair systems. Furthermore, skin repair is not the result of a single active ingredient working in isolation; rather, it stems from the rational combination of different repair pathways. Based on our research achievements and product accumulation, Plamed has built a comprehensive repair solution system covering tissue repair, classic repair, cellular protection, and soothing support, helping customers secure more flexible options.
Discovery Date: June 2026
Endogenous Exfoliation:
From KLK7/SPINK5 Dual-Target Regulation to Autologous Skin Renewal
Traditional exfoliation relies predominantly on external interventions such as physical abrasion, chemical peeling, or enzymatic degradation to induce passive stratum corneum shedding. In recent years, the industry has turned its attention toward “endogenous exfoliation,” the core of which lies in activating the skin’s intrinsic metabolic pathways to achieve a more physiological renewal of the stratum corneum.
Focusing on this direction, Plamed initiated research on the active constituents of white willow bark. Through AI prediction, mechanistic studies, multi-model validations, and in vivo tests, we have systematically explored the regulatory pathways of KLK7/SPINK5 in stratum corneum renewal, establishing a complete and rigorous evidence system for endogenous exfoliation.
- Endogenous Exfoliation Research
- KLK7/SPINK5 Dual-Target Regulation
- Multi-Level Research Validation
1. Endogenous Exfoliation Research
Studies have revealed that the active constituents of white willow bark can participate in the modulation of the stratum corneum regulatory enzyme system via the KLK7 and SPINK5 pathways, providing mechanistic research support for endogenous exfoliation.
2. Multi-Level Research Validation
From AI-assisted target prediction to mechanistic studies, 3D skin models, ex vivo pig skin models, and in vivo tests, a full-loop evidence system has been constructed. The stable, efficient, and mild exfoliating performance was validated across different concentrations at in vivo tests.
3. Plamed’s Perspective
Endogenous exfoliation introduces a novel exploratory paradigm for skin desquamation research. By activating the human skin’s inherent stratum corneum regulatory enzymes to promote the natural shedding of corneocytes, “autologous skin renewal” can be achieved. This provides an innovative solution for developing products that successfully balance high efficacy and skin mildness.