Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool and dry place and away from direct sunlight and oxidizing agents.
Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
In recent years, the appearance of sensitive skin has become more and more frequent, which significantly affects people’s life quality and increases their psychological pressure and anxiety. Sensitive skin has now become a health issue of global concern. According to the data of China Sensitive Skin Diagnosis and Treatment Expert Consensus, the proportion of Chinese women with sensitive skin is about 36.1%, which means that one out of three people has sensitive skin.
Currently, the mainstream anti-irritation target is TRPV1, while the human body senses external stimuli from the TRPV family, there are six known, from TRPV1 to TRPV6. If the anti-irritation ingredient is only effective on TRPV1, and most likely insensitive to other TRPV receptors, it is not sufficient to comprehensively cover all sources of stimuli to which the skin is subjected. The market needs a new anti-irritant target that not only synergizes with the TRPV1 target, but also inhibits the stimulus signals generated when all TRPV receptors are activated.
Therefore, after many years of in-depth research by Plamed, it was found that Kava Pepper Root Extract is able to directly affect the transmission of stimulus signals-AP generated by the activation of various TRPV receptors through a novel mechanism of action. It has a broader and more reliable anti-irritating effect.
| Product name | PMSoothe® Kava97 |
| INCI name | PIPER METHYSTICUM ROOT EXTRACT,
HYDROXYPROPYL CYCLODEXTRIN |
| Actives content | Kavain≥4000ppm
Yangonin≥500ppm |
| Solubility | Water-soluble |
| Recommended dosage | 0.1%~2% |
| Function | Anti-irritation |
| Highlights★ | Dual targets anti-irritation（TRPV1 , AP） |
Kava has been eaten for 3,000 years in the South Pacific islands, where it is considered “sacred” by the indigenous people and used in religious and cultural ceremonies. Kava is used to make “Kava Wine”, which is considered the national drink and is consumed when entertaining VIP guests, holding important festivals or discussing important matters. Kava is considered a natural answer to stress, anxiety, depression, insomnia and more.
Plamed has conducted efficacy demonstration and mechanism of action research on Kava to soothe sensitive skin, and in 2021 verified that Kava can block neurotransmitter transmission.
Based on neurons, PMSoothe® Kava97 at 0.45% concentration can inhibit AP (AP) induced frequency by 89.34%.
Based on keratinocytes: PMSoothe® Kava97 inhibited capsaicin receptor (TRPV1) by 35.64% and 41.58% at concentrations of 0.08% and 0.25%, respectively. The effect at the same concentration was close to that of 4-tert-butylcyclohexanol.
Based on chick embryo chorioallantoic test: 0.5% PMSoothe® Kava97 reduces the moderate irritation of salicylic acid to a mild irritation. 0.5% PMSoothe® Kava97 reduces the moderate irritation of vitamin A to no/light irritation. 0.5% PMSoothe® Kava97 reduces the moderate irritation of phenylethyl resorcinol to no irritation.
Based on zebrafish test: PMSoothe® Kava97 at 0.25% concentration has nerves soothing effect as high as 97%.
Stimulate the faces of 30 eligible subjects with sensitive skin with 0.01% capsaicin, then use a single application of the product PMSoothe® Kava97, as a result, there are significant improvements in the area of red areas of the skin and a-values at all time points compared to the matrix control group.
The recognition degree of 30 subjects after using the product for 30 minutes: The faces of 30 eligible subjects with sensitive skin were stimulated with 0.01% capsaicin, and then after a single 30-min application of the product, it was felt that the product was able to provide 100% relief from burning and tingling of the skin, 93.55% relief from itchy sensations, and 83.87% relief from redness and other phenomena of the skin.
Plamed Kava Extract uses advanced green supercritical extraction technology. In this technology, CO2 is compressed into a liquid as an extraction solvent, replacing chemical solvents such as ethyl acetate and methanol. After extraction, we also have CO2 recovery technology, the residual amount of CO2 in the final product is lower than the CO2 content in the air.
Our extraction temperature is around 45℃, which is lower than the maximum ambient temperature; and preserves as much as possible the natural active ingredient of kava root: kavalactones, compared to the conventional extraction temperature of 80℃ to 90℃.
This green manufacture process make PMSoothe® Kava97 the safest, effective, environmentally friendly.
PMSoothe® Kava97 blocks the production of burning, pain and itching through two targets simultaneously, mainly acting on the skin sensory nervous system. It can inhibit both neural excitation (inhibiting TRPV1 protein expression) and neurotransmitter transmission (inhibiting AP signaling), thus achieving instant nerve relief.
Compared to traditional TRPV1 target, inhibition of action potentials (APs) blocks multiple stimulus signals more comprehensively. There are multiple receptor subtypes such as TRPV1-TRPV6 distributing in human skin, which perceive different stimuli respectively. Traditional TRPV1 inhibitors have the limitation of having a single target of action. However, regardless of which TRPV receptors is activated, the stimulus signals generated ultimately need to be transmitted to the brain in the form of AP. Therefore, inhibition of the AP can maximize the blockage of the transmission of various stimulus signals and provide a broader anti-irritation effect.
There was no significant color change or precipitation of Plamed Kava pepper root extract after 1 year at different pH, low (4°C), room (20-30°C) and high (45°C) temperatures.
PMSoothe® Kava97 has no irritation at the concentration of 1%, based on vitro eye irritation test.
According to Test–Human skin patch test, skin adverse reactions occurred in 0 out of 30 people in 48 hours using 2% PMSoothe® Kava97.
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool and dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional SAnti-irritating cosmetics ingredient PMSoothe® Kava97 manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good SAnti-irritating cosmetics ingredient PMSoothe® Kava97 and good Anti-irritating cosmetics ingredient PMSoothe® Kava97 price will help customers make good terminal products and help customers win a lasting and broad market.
A: Traditional 4-tert-butylcyclohexanol targets only a single TRPV1 receptor. Beyond TRPV1 inhibition, PMSoothe® Kava97’s ultimate advantage lies in its ability to block Action Potentials (AP). No matter which peripheral receptor mediates the irritation, the signals must convert into AP to reach the brain, giving PMSoothe® Kava97 a much broader and more comprehensive anti-irritant and soothing effect.
A: In human clinical trials, the inclusion criteria strictly selected female subjects “presenting with facial expression lines and dynamic wrinkles.” However, during evaluation, subjects must maintain a relaxed facial expression, meaning the lines captured and quantified by instruments physically present as static. The highly significant improvement in data precisely proves that the product is remarkably effective in smoothing the wrinkles left by dynamic expressions.
A: The study utilizes SLS (Sodium Lauryl Sulfate) to construct a skin barrier damage model. Once damaged, the barrier cannot easily self-restore to its baseline healthy state (blank control) in the short term. Taking the healthy skin state as the ideal reference, higher repair data indicates a stronger capacity to drive the damaged skin back to normalcy.
A: The choice primarily depends on your formulation forms. PMSoothe® Kava-Oil was launched to assist formulators in developing pure anhydrous systems. In terms of cost-effectiveness based on active content, Kava Oil doubles the Kavain concentration while the price increase is marginal, making it exceptionally cost-effective.
A: Yes. Against 6 classic surfactant combination models frequently used in rinse-off products (including SLS/SLES, amino acid surfactants, and betaines), tests show that 1% PMSoothe® Kava 97 effectively reduces moderate surfactant-induced irritation down to non-irritation. Furthermore, for selenium disulfide (a common anti-dandruff agent), 1% PMSoothe® Kava 97 successfully mitigates its mild irritation to a non-irritating level.
A: Yes. Compatibility reports show that adding PMSoothe® Kava 97 into a neutralized Carbomer system or natural polymer thickening systems does not affect viscosity (it is recommended to add it post-neutralization).
Note: If added to highly ion-sensitive thickeners (such as AVC or EMT-10), a slight viscosity drop may occur, which can be compensated for by slightly increasing the thickener dosage. Additionally, it may cause mild haziness with EMT-10, so pairing them in crystal-clear transparent formulas is not recommended.
A:Discoloration Risk: Tranexamic acid solutions exhibit a high pH (7–8). Kava carries an aggravated risk of yellowing when stored long-term in environments with pH≥7. It is advised to adjust the final formulation pH to around 6 to maintain optimal stability.
Formulation Guide: PMSoothe® Kava 97 is fully compatible with water-based serums and commonly-used thickeners. In HET-CAM anti-irritation tests against 377, a dosage of 0.5%–1% significantly reduced the irritation of the whitening actives, helping prevent post-inflammatory hyperpigmentation (PIH) caused by irritation.
A: Yes, PMSoothe® Kava 97 delivers far superior performance. PMSoothe® Kava 97 represents our third-generation upgraded Kava ingredient, utilizing advanced SPEX extraction technology. The content of its core active Kavain is twice that of PMSoothe® 9728, and Kava 97 implements internal controls over the ratios of six active components, completely outperforming PMSoothe® 9728 in both efficacy and batch stability.
A: The crucial differences lie in active concentration and safety. The soothing kavalactones are primarily concentrated in the roots and rhizomes of the plant. “Root, stem, and leaf extracts” dilute the active concentrations due to the heavy leaf mass and introduce alkaloids from the leaves that carry potential hepatotoxicity risks. Thus, pure root extraction is vastly superior in both efficacy and safety.
Q1: Precipitation after 7 days under refrigeration?
A：Our internal stability tests confirm no precipitation for up to 5 months under low temperatures. Precipitation in a finished formula is typically caused by compounding with high-molecular polymers or polysaccharides (like sodium hyaluronate or xanthan gum), which reduce free water availability. Try restoring to room temperature or heating slightly (below 45°C) to see if it re-dissolves.
Q2：Any negative impact if added at 80–90°C for 30 minutes during production?
A：No impact. PMSoothe® Kava 97 contains hydroxypropyl beta-cyclodextrin (spray-dried at over 100°C), and the active extract undergoes an 8-hour drying stage at 75°C during manufacturing without any degradation.
Q3：Difficult to dissolve via manual stirring?
A：We recommend using standard mechanical or magnetic stirrers in the lab, which will dissolve it rapidly; mild heating can also significantly accelerate dissolution.
Q4：When testing the anti-irritant efficacy, is it better to test the raw material aqueous solution directly or to make it into a basic formula?
A：For rapid screening or evaluating the raw material’s inherent ability to block a specific irritant, a simple aqueous dilution is sufficient. However, to test its buffering capacity within a complex formulation, or to evaluate long-term anti-wrinkle/repair effects, formulating it into a base formulation is highly recommended.
A: The efficacy is relatively limited due to divergent pathways. Histamine-induced pathways: This follows a “trigger-first, conduct-later” GPCR cascade. Histamine activates H1 receptors, multiplying internal second-messenger signals inside cells. Kava operates primarily via “ion-channel interception” and downstream “AP blocking”. Because the upstream GPCR signals have already amplified, downstream interception yields limited results. Kava’s Strength (Non-histamine irritations): Kava excels against stinging, heating, and burning induced by capsaicin or physical stimuli, because these follow a direct “neuronal firing” mode highly dependent on Action Potentials, which Kava cuts off directly at the master switch.
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