Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Bisabolol, also known as α-bisabolol or levomenol, is a monoterpene compound and the most widely used soothing and repairing active ingredient in the cosmetics industry. Currently, there are three primary production methods: biological fermentation, natural plant extraction, and chemical synthesis. Plamed dopts a natural fermentation approach, utilizing advanced microbial fermentation technology to produce (-)-α-Bisabolol identical to its natural plant counterpart. This cosmetic-grade product boasts a purity ≥98% and strictly controlled allergen levels ≤0.05%, offering high activity, thermal stability, and green sustainability. The core biological activities of bisabolol include: blocking classic inflammatory signaling pathways (NF-κB and MAPK), downregulating pro-inflammatory factor release to reduce inflammatory responses; simultaneously enhancing skin barrier function and promoting self-repair of damaged tissues. It also exhibits broad-spectrum antibacterial and antioxidant properties. Thus, it delivers anti-inflammatory soothing, barrier repair, antibacterial acne control, and auxiliary brightening/antioxidant skincare benefits. Cosmetics incorporating this ingredient alleviate sensitive skin concerns like redness, stinging, dryness, and itching, accelerate damaged barrier repair, and improve acne inflammation. suiting the needs of sensitive skin, post-medical aesthetic procedures, and acne-prone complexions. It is widely incorporated into soothing repair, acne treatment, post-sun care, and anti-sensitivity stabilizing cosmetics.
| Product Name | CAS Number | INCI Name | |
| Bisabolol | 23089-26-1 | BISABOLOL | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| C15H26O | 222.37g/mol |  |
|
| Product ID | Specification | Minimal Package | MOQ |
| PMM3401 | Purity≥98.0% | 1KG | 1KG |
Cosmetic-grade bisabolol is produced through biofermentation, natural plant extraction, and chemical synthesis. Plamed employs biofermentation technology to achieve large-scale production of high-purity (-)-α-bisabolol. This approach eliminates supply chain risks associated with seasonal and geographical constraints of plant extraction while avoiding the use of organic solvents in chemical synthesis. It represents an ideal choice that balances green sustainability with exceptional efficacy.
| Biological fermentation method | Natural plant extract | Chemical synthesis | |
| Raw materials | Food-grade glucose carbon source substrate (renewable resource) | Chamomile, spring chrysanthemum, and other Asteraceae plants | Chemical precursors |
| Specific process | High-density fermentation using microorganisms (such as yeast) is employed to achieve targeted biosynthetic pathways, followed by molecular distillation to obtain high-purity products. | Obtained through processes such as distillation and purification following extraction using supercritical CO₂ or organic solvents. | Prepared via chemical synthesis reactions, followed by purification after multi-step synthesis. |
| Advantages | Green and sustainable, high-purity single configuration, batch consistency, pure and safe, stable production capacity. | Plant-based extracts enjoy high market recognition and mature application. | Large-scale production offers low costs and outstanding value for money. |
| Disadvantages | High technical requirements necessitate substantial upfront R&D investment. | Supply chain stability is poor due to seasonal and regional variations; Purity fluctuates significantly, with potential risks of pesticide residues. | Racemic mixtures contain high levels of impurities and pose significant compliance risks; they exhibit lower mildness and bioactivity compared to the levorotatory form. |
| TEST ITEMS | SPECIFICATION |
| Purity | ≥98.0% |
| Content | ≥95.0% |
| Farnesol | ≤0.05% |
| Organoleptic | |
| Appearance | Viscous liquid |
| Color | Colorless to light yellow |
| Odor | Characteristic |
| Physical Characteristics | |
| Specific optical rotation | -58.0°~ -55.0° |
| Refractive index | 1.485 ~ 1.497（20℃） |
| Relative density | 0.920 ~ 0.936（20℃/4℃） |
| Heavy Metal | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microorganism Test | |
| Total plate count | ≤100 cfu/g |
| Yeast & mold count | ≤50 cfu/g |
| Pseudomonas aeruginosa | Not detected |
| Staphylococcus aureus | Not detected |
| Heat-resistant escherichia coli | Not detected |
Beta-sitosterol can block the NF-κB and MAPK classical inflammatory signaling pathways, dose-dependently downregulating the transcription and release of pro-inflammatory factors IL-1β, IL-6, TNF-α, and leukotriene B4. Simultaneously, it interrupts the skin inflammation cascade, rapidly alleviating sensitivity discomforts such as redness, stinging, itching, and edema caused by external irritants or barrier damage. Studies demonstrate that L-alpha-bisabolol provides effective soothing for both allergic skin and pediatric skin, with significantly superior efficacy compared to synthetic racemic mixtures. Consequently, bisabolol rapidly alleviates skin sensitivity and discomfort while inhibiting inflammatory responses, establishing it as a core active ingredient for sensitive skin care.
Beta-sitosterol promotes proliferation and differentiation of human keratinocytes, upregulates the gene and protein expression of filaggrin, loricrin, and occludin—the three core structural proteins of the skin barrier. It strengthens the stratum corneum, reduces transepidermal water loss (TEWL), accelerates the regeneration and repair of damaged skin barriers, and fundamentally enhances the skin’s moisture retention capacity and resistance to external irritants. Therefore, Bisabolol effectively repairs compromised skin barriers, fortifies the skin foundation, and reduces the likelihood of recurrent redness and sensitivity in sensitive skin.
Beta-sitosterol exhibits broad-spectrum antibacterial activity while suppressing inflammatory reactions at acne lesions. It reduces inflammation and swelling in red, inflamed pimples, accelerates their resolution, and minimizes post-acne marks. Unlike antibiotics, it carries no risk of developing resistance and is gentle on acne-prone skin without compromising the skin barrier. Therefore, Bisabolol gently improves inflammatory acne, regulates the skin microbiome, and meets the acne-fighting and repair needs of oily and acne-prone skin.
Bisabolol scavenges DPPH radicals, hydroxyl radicals, and superoxide anions, inhibits lipid peroxidation, and reduces damage to skin caused by UV-induced reactive oxygen species (ROS). It also inhibits tyrosinase activity to reduce melanin production and alleviates skin irritation caused by whitening ingredients (such as retinol, niacinamide, and acids), enhancing the gentleness and tolerability of whitening products.
| Product | Reference Dosage |
| Bisabolol (purity≥98.0%) | 0.1%~1.0% |
Notes:
Bisabolol application cases in major cosmetic brands in the world:
| Country | Brand | Product |
| China | Winona | Clear Sunscreen Lotion |
| PROYA | Everbright Whitening & Anti-Spot Crystal Lotion | |
| Canada | The Ordinary | Soothing & Barrier Support Serum |
| USA | Estée Lauder | Advanced Night Repair Synchronized Multi-Recovery Complex |
| France | La Roche-Posay | Cicaplast B5 Repair Serum |
| L’Oréal Paris | Revitalift Filler Hyaluronic Acid Anti-Wrinkle Plumping Cream | |
| Clarins | Double Serum Complete Age Control Concentrate |
Package: 1kg/bag, 25 bags packed in cardboard drums lined with double-layer plastic bags.
Storage: Store in a dry, well-ventilated area away from direct sunlight and high temperatures. and oxidizing agents.
A: To meet strict global standards and diverse market needs, our cosmetic ingredients are certified under major international systems:
ISO 9001:2015 (Quality Management System): Guarantees that our manufacturing processes—from raw material sourcing to final production—adhere to strict quality control standards. Ensures consistent batch-to-batch stability, which is essential for our clients in the Europe and US markets looking for premium, compliant, and reliable supply chains.
Halal Certification: Fully certified Halal, ensuring compliance with strict ingredient traceability and the absence of prohibited substances or cross-contamination.
Allows our partners to seamlessly enter and expand in the Southeast Asian (e.g., Indonesia, Malaysia) and Middle Eastern markets, meeting local regulatory mandates.
We are committed to providing fully traceable, high-quality, and compliant ingredients to support your brand’s global growth. If you need copies of our certificates or specific technical documentation (such as COA, MSDS, or compliance statements), please feel free to contact our team.
A: Yes, absolutely. Regulatory compliance and safety are our top priorities. All of our premium active ingredients have standard, internationally recognized INCI names and are fully compliant with the stringent regulations of these major markets:
European Union: Fully compliant with the EU Cosmetic Regulation (EC) No 1223/2009, including safety assessments, and banned/restricted substance lists.
United States: Formulated and manufactured in strict accordance with FDA guidelines and the latest MoCRA (Modernization of Cosmetics Regulation Act) requirements, ensuring smooth product registration and listing.
South Korea: Compliant with the regulations set by the MFDS (Ministry of Food and Drug Safety), meeting their strict standards for functional cosmetic ingredients and efficacy documentation.
Whether you are a distributor or a brand owner in Europe, the Americas, or Southeast Asia, you can seamlessly integrate our ingredients into your formulations. We provide comprehensive regulatory support dossiers (COA, TDS, MSDS, and Composition Statements) to facilitate your local product promotion.
A: Yes, we provide comprehensive efficacy dossiers for all our flagship ingredients (such as PMSoothe® Kava97, PCR® Supermolecule Escin, and PMRefresh® Willow). Our data packages include:
In-vitro (cell-based) test reports to demonstrate cellular-level activihttphttp://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/ty and pathways.
In-vivo (human clinical) trial data to prove real-world visible results.
Safety assessments and clear Mechanism of Action (MOA) diagrams.
These rigorous, science-backed materials are designed to help our distributors easily convince formulation chemists and premium brand owners.
A: Absolutely. We support our partners’ R&D efforts through a two-step support system:
Free Samples: We provide complimentary samples for laboratory evaluation and pilot trials.
Technical & Formulation Support: To accelerate your application process, we will also provide formulation guides for you.
Our dedicated technical support team is also available to help your customers resolve challenges related to formulation stability, compatibility, and optimal dosage.
A: We empower our global distributors with a comprehensive suite of “Turn-key” Marketing Kits to minimize your promotional costs and time-to-market. Our support includes:
Technial Documentation: Product brochures, white papers, and TDS, MSDS, and COA.
Visual Materials: Ingredient videos and ready-to-use social media posters.
Market Intelligence: Detailed competitive analysis reports and trend insights.
Co-Marketing: We also attend at major international cosmetics exhibitions to boost local brand awareness.
A: Yes, we strictly adhere to a win-win, distributor-first channel policy:
Any direct inquiries, sample requests, or business leads received through our website or international trade shows from an authorized region will be precisely forwarded to our local exclusive or authorized distributor.
We protect your market efforts and actively help you convert local brand clients into long-term order.
A: We offer highly flexible logistical terms to support your business:
Minimum Order Quantity (MOQ): For most of our active ingredients, the MOQ is as low as 1 kg, allowing high flexibility for your inventory management.
Lead Time: Our standard lead time is highly competitive. Products are typically dispatched within 3 to 5 working days upon receipt of payment, subject to specific product availability and shipping logistics.
A: We maintain an open, strategic, and highly supportive attitude toward building exclusive global partnerships. We evaluate potential distributors based on:
Local distribution channels and market expertise.
Annual purchase volume projections.
Market expansion and promotional plans.
If you are interested in growing with us, please click the [Apply Now] to contact our business manager, and we will answer everything you would like to know.
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