Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1, also known as Palmitoyl Oligopeptide, is a classic collagen-promoting signal peptide and a core active ingredient for root-cause anti-aging, firming and wrinkle-reducing skincare.

Cosmetic-grade Palmitoyl Tripeptide-1 is chemically synthesized in compliance with regulations. Plamed produces the ingredient via Solid Phase Peptide Synthesis (SPPS), stably supplying high-purity ≥98.0%; the internal control standard for active peptide content is ≥80.0%, with batch test values reaching up to 85.1%.

Chloride ions may derive from salt formation adjustment and neutralization during peptide manufacturing, existing in various forms in the system. Plamed has established a scientific chloride content control range, optimizing the industry’s conventional free hydrochloric acid detection index. Traditional hydrochloric acid content is calculated indirectly via chloride conversion, involving salt-form assumptions and conversion errors. Based on analysis of potential salt-forming sites of Palmitoyl Tripeptide-1, we set a reasonable control range with reference to the theoretical maximum salt-forming chloride content for batch stability management. This indicator is accurate and unambiguous, helping reduce formulation fluctuation risks, shorten formulation adjustment cycles, and improve formulation development efficiency and long-term finished product stability.

As a classic Matrikine-mimetic peptide, Palmitoyl Tripeptide-1 simulates active fragments released during collagen degradation (represented by type I collagen-related signal sequences), sending “collagen regeneration” signals to skin fibroblasts and triggering the self-repair mechanism of the dermis. It regulates collagen synthesis-related signaling pathways such as TGF-β/Smad, enhances fibroblast activity, and upregulates the expression of key extracellular matrix (ECM) components, including type I/III collagen, elastin, fibronectin and glycosaminoglycans. It also helps regulate matrix metalloproteinase (MMPs) activity to reduce excessive collagen degradation, forming a two-way regulatory mechanism of “promoting synthesis + inhibiting degradation”, thereby improving the structural integrity and stability of the dermis.

In addition, by promoting ECM reconstruction, it improves the skin microenvironment, indirectly optimizes keratinocyte function, upregulates the expression of barrier-related proteins (e.g., filaggrin), strengthens skin barrier integrity, and reduces transepidermal water loss (TEWL).

With its signal-activated anti-aging mechanism, Palmitoyl Tripeptide-1 fundamentally improves dry lines, fine lines, skin sagging and loss of elasticity caused by collagen loss, achieving comprehensive effects including wrinkle reduction, firming, structural support enhancement and photoaging repair. It is widely used in high-end anti-aging, firming, wrinkle-reducing and barrier-repairing skincare products.

Product Name	CAS	INCI
Palmitoyl Tripeptide-1	147732-56-7	Palmitoyl Tripeptide-1
Molecular Formula	Molecular Weight	Molecular Structure
C30H54N6O5	578.8g/mol
Product ID	Specification	Minimal Package	MOQ
PMKZ3001	Purity≥98% Peptide content≥80%	10g	10g