Skin soothing ingredients designed to calm irritation and support sensitive skin care.
Skin irritation involves multiple sensory receptors, not only TRPV1. Because these signals interact through complex pathways, single-target approaches may not fully address skin irritation.
Plamed introduced Action Potential (AP), a common convergence point for skin irritation signals, into cosmetic anti-irritation research. Based on this approach, Plamed developed an AP neural anti-irritation pathway designed to regulate irritation signals and provide broad-spectrum soothing benefits.
PMSoothe® Kava97 is a neural anti-irritation active derived from kava root and developed through Plamed’s AP neural anti-irritation pathway research. It helps regulate TRPV1 expression and action potential transmission by targeting the reception and transduction of irritation signals, providing broad-spectrum soothing and anti-irritation benefits for skin.
Its broad-spectrum anti-irritation performance makes it suitable for sensitive skin care, chemical exfoliation, and scalp care formulations.
