Name: Skin Repair Ingredient PMRepair® Centella
Brand: Plamed Green Science
SKU: –

Overview

Centella Asiatica Extract’s main active ingredients are asiaticoside, madecassoside, asiatic acid and madecassic acid. Madecassoside and madecassoside belong to triterpenoid saponins, and asiatic acid and madecassic acid belong to triterpene acid compounds. Scientific research has proved that Centella asiatica, as a traditional Chinese herbal medicine, has skin care effects such as repairing, anti-inflammation, whitening, and anti-oxidation. Centella asiatica is rich in a variety of biological active substances, and is a natural medicinal plant resource worthy of exploration and development.

PMRepair® Centella released by Plamed is a natural cosmetic material that can be soluble in water or butanediol with excellent skin repair and anti-inflammatory effects.

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Product Name	INCI Name	CAS No.	MOQ
PMRepair® Centella	CENTELLA ASIATICA EXTRACT	84696-21-9	1kg

Source

Centella asiatica also known as Gotu Kola, is the dry whole plant of Centella asiatica (L.) Urban. It is a perennial creeping herbaceous plant with slender stems. Centella Asiatica is native to India and is now widely distributed in tropical and subtropical regions of the world. Centella asiatica has a medicinal history of more than 2,000 years in my country. Many other countries and regions, such as Madagascar, South Africa, India, Southeast Asian countries and South America, also use Centella asiatica as a brain medicine, diuretic, and leprosy and ulcer. The main active ingredients of Centella asiatica extract that can be used in cosmetics are asiaticoside and madecassoside, asiatic acid and madecassic acid.

Technical Data

Product Name	Product ID
PMRepair® Centella	PMRP0101

Organoleptic Tests
70% Total Triterpenes (Asiaticoside + Madecassoside + Asiaticoside B)	≥70%
Appearance	Off-white to pale yellow powder
Odor	Characteristic
Physical Characteristics
Moisture	≤10.0%
Ash content	≤7.0%
Heavy Metals
Pb	≤10ppm
As	≤2ppm
Hg	≤1ppm
Cd	≤5ppm
Microbiological Tests
Total of bacteria	≤1000cfu/g
Yeast & mold	≤100cfu/g
Pseudomonas aeruginosa	Not detected
Staphylococcus aureus	Not detected
Heat-resistant escherichia coli	Not detected

Mechanism & Effects

Repair Skin Barrier

Plamed has done the test of in vitro 3D epidermis skin model repairing efficacy, using the anionic surfactant Sodium lauryl sulfate (SLS) to stimulate the 3D epidermal skin model to construct an in vitro skin injury model. After PMRepair® Centella sample is applied, the tissue morphology, filaggrin (FLG), loricrin (LOR) and transglutaminase 1 (TGM1) are used to evaluate the repairing efficacy of PMRepair® Centella.

The test results are as follows:

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Dosage

PMRepair® Centella	Recommended dosage
Leave-on cosmetics	0.1%~0.5%
Wash-off cosmetics	0.1%~0.5%

Note: PMRepair® Centella at a concentration of 0.15% has been tested with very good efficacy results based on 3D epidermal skin modeling, so the recommended dosage is 0.1%-0.2%.

Solubility

The water solution of PMRepair® Centella is clear and transparent, but the solution will be cloudy and opaque when stand for a long time.

Therefore, the following dissolution methods can be chosen:

① 35% butylene glycol, 65% deionized water. The solution is clarified and transparent after a long time.

② Pure water. At 0.1% and 0.2% concentration and PH value below 6, the aqueous solution is clear and transparent.

From left to right: 0.1% aqueous solution; 0.1% aqueous solution + 0.5% phenoxyethanol;

0.1% aqueous solution, PH=5; 0.1% aqueous solution, PH=6.

From left to right: 0.2% aqueous solution; 0.2% aqueous solution + 0.5% phenoxyethanol;

0.2% aqueous solution, PH=5; 0.2% aqueous solution, PH=6.

Safety

·China has included Centella Asiatica Extract in The International Catalogue of Chinese Cosmetic Raw Materials Standards (2010 edition) published by CAFFCI and On the Announcement of Name List of Cosmetics Raw Materialissued by CFDA in 2014. There are no reports showing that is unsafe for external use.
·CTFAhas specified Centella Asiatica Extract as a raw material for cosmetics.
·Centella Asiatica Extractis listed in The List of Used Cosmetic Ingredient approved by the Ministry of Health of the People’s Republic of China in 2001.
·Plalmed tested cytotoxicity assay of PMRepair®Centella, and the results showed that PMRepair® Centella based on keratin-forming cells does not show significant cytotoxicity in the range of 0.1563 mg/mL.

Packing & Storage

Package: Packed in aluminum foil bag, 1kg/bag.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

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