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Skin Repair Ingredient PMRepair® Centella

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Skin Repair Ingredient PMRepair® Centella

  • Cost-effective, the test concentration and price are one-third of 95% asiaticoside, but the repairing effect is far more than asiaticoside.
  • Soluble in water or butanediol, easy to be formulated into cosmetics.
  • High quality centella asiatica plant as the raw material for extraction.
Plamed is the largest Skin Repair Ingredient PMRepair® Centella supplier in China with good price and high quality. Where to buy Skin Repair Ingredient PMRepair® Centella with reasonable price and high quality? Where to find good information of wholesale Skin Repair Ingredient PMRepair® Centella? As the professional Skin Repair Ingredient PMRepair® Centella manufacturer, Plamed is your best choice.

Centella Asiatica Extract’s main active ingredients are asiaticoside, madecassoside, asiatic acid and madecassic acid. Madecassoside and madecassoside belong to triterpenoid saponins, and asiatic acid and madecassic acid belong to triterpene acid compounds. Scientific research has proved that Centella asiatica, as a traditional Chinese herbal medicine, has skin care effects such as repairing, anti-inflammation, whitening, and anti-oxidation. Centella asiatica is rich in a variety of biological active substances, and is a natural medicinal plant resource worthy of exploration and development.

PMRepair® Centella released by Plamed is a natural cosmetic material that can be soluble in water or butanediol with excellent skin repair and anti-inflammatory effects.

Product Name INCI Name CAS No. MOQ
PMRepair® Centella CENTELLA ASIATICA EXTRACT 84696-21-9 1kg

Centella asiatica also known as Gotu Kola, is the dry whole plant of Centella asiatica (L.) Urban. It is a perennial creeping herbaceous plant with slender stems. Centella Asiatica is native to India and is now widely distributed in tropical and subtropical regions of the world. Centella asiatica has a medicinal history of more than 2,000 years in my country. Many other countries and regions, such as Madagascar, South Africa, India, Southeast Asian countries and South America, also use Centella asiatica as a brain medicine, diuretic, and leprosy and ulcer. The main active ingredients of Centella asiatica extract that can be used in cosmetics are asiaticoside and madecassoside, asiatic acid and madecassic acid.

Product Name Product ID
PMRepair® Centella PMRP0101

 

Organoleptic Tests
70% Total Triterpenes
(Asiaticoside + Madecassoside + Asiaticoside B)		 ≥70%
Appearance Off-white to pale yellow powder
Odor Characteristic
Physical Characteristics
Moisture ≤10.0%
Ash content ≤7.0%
Heavy Metals
Pb ≤10ppm
As ≤2ppm
Hg ≤1ppm
Cd ≤5ppm
Microbiological Tests
Total of bacteria ≤1000cfu/g
Yeast & mold ≤100cfu/g
Pseudomonas aeruginosa Not detected
Staphylococcus aureus Not detected
Heat-resistant escherichia coli Not detected
  • Repair Skin Barrier

Plamed has done the test of  in vitro 3D epidermis skin model repairing efficacy, using the anionic surfactant Sodium lauryl sulfate (SLS) to stimulate the 3D epidermal skin model to construct an in vitro skin injury model. After PMRepair® Centella sample is applied, the tissue morphology, filaggrin (FLG), loricrin (LOR) and transglutaminase 1 (TGM1) are used to evaluate the repairing efficacy of PMRepair® Centella.

The test results are as follows:

Based on the 3D epidermal skin model (EpiKutis®), compared with the control group, the tissue morphology of the sample PMRepair® Centella at a concentration of 0.15% was significantly improved, and the thickness of the living cell layer was significantly increased, with an increase rate of 49.39%. Filaggrin (FLG), loricrin (LOR), and transglutaminase 1 (TGM1) contents all increased significantly, with the increase rates being 150.00%, 646.15%, and 537.14% respectively. It indicates that PMRepair® Centella can improvetissue morphology at 0.15% concentration, promote skin tissue recovery and increase the content of barrier-related proteins (FLG, LOR, TGM1) to achieve repairing effects.

Based on skin barrier permeability test of zebrafish embryo, PMRepair® Centella has a significant skin barrier repair effect at a lower dose of 0.1%, the repairing rate is 53%; while Asiaticoside (95%) has no repairing effect or has a weak repairing effect at either low or high doses.

  • Anti-inflammation & Anti-bacteria

NF-κB signaling pathway is closely related to inflammatory response and plays an important role in regulating cellular inflammatory response: when cells are stimulated, NF-κB can be activated, thereby causing inflammatory factors TNF-α, IL-1β, IL-2, IL-6, nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2)’s over-expression.

Relevant studies have found that Centella asiatica extract can down-regulate the expression of nitric oxide (NO), TNF-α, and IL-6 by inhibiting the NF-κB signaling pathway, thereby exerting anti-inflammatory effect. Centella asiatica extract can also play an anti-inflammatory role by regulating the heme oxygenase 1 (HO-1) signaling pathway, inhibiting the production of pro-inflammatory factors and the activity of peroxidase.

In addition, Centella asiatica extract has a certain inhibitory effect on Pseudomonas aeruginosa, Staphylococcus aureus, and acne bacillus. Asiatic acid can dissolve the outer wax film of bacteria to be killed by other drugs or body defense tissues. Asiatic acid and glycosides for external use can promote wound healing, stimulate granulation, promote epidermal keratinization or epidermal regeneration, and help generate connective tissue. Centella asiatica extract can reduce the production of pro-inflammatory mediators (IL-1, MMP-1), improve and repair the skin’s own barrier function, thereby preventing and correcting skin immune dysfunction.

  • Anti-oxidation

Centella asiatica extract also has a strong antioxidant effect, which can inhibit free radical activity. Oxidation is one of the important causes of skin aging. Radiation and air pollution in the external environment will cause the body to produce free radicals. Free radicals are active substances that lack electrons. After entering the human body, they easily snatch electrons from cells and cause cell distortion. This is the root cause of human aging and disease. Specialists studied the antioxidant activity and total phenolic compounds of the roots, leaves and petioles of four species of Centella asiatica, and the results showed that the leaves and roots of Centella asiatica had high antioxidant activity, and their antioxidant activity was closed to that of Tocopherol.

PMRepair® Centella Recommended dosage
Leave-on cosmetics 0.1%~0.5%
Wash-off cosmetics 0.1%~0.5%

Note: PMRepair® Centella at a concentration of 0.15% has been tested with very good efficacy results based on 3D epidermal skin modeling, so the recommended dosage is 0.1%-0.2%.

The water solution of PMRepair® Centella is clear and transparent, but the solution will be cloudy and opaque when stand for a long time.

Therefore, the following dissolution methods can be chosen:

① 35% butylene glycol, 65% deionized water. The solution is clarified and transparent after a long time.

② Pure water. At 0.1% and 0.2% concentration and PH value below 6, the aqueous solution is clear and transparent.

From left to right: 0.1% aqueous solution;   0.1% aqueous solution + 0.5% phenoxyethanol;

0.1% aqueous solution, PH=5;   0.1% aqueous solution, PH=6.

From left to right: 0.2% aqueous solution;   0.2% aqueous solution + 0.5% phenoxyethanol;

0.2% aqueous solution, PH=5;   0.2% aqueous solution, PH=6.

  • China has included Centella Asiatica Extract in The International Catalogue of Chinese Cosmetic Raw Materials Standards (2010 edition) published by CAFFCI and On the Announcement of Name List of Cosmetics Raw Materialissued by CFDA in 2014. There are no reports showing that is unsafe for external use.
  • CTFAhas specified Centella Asiatica Extract as a raw material for cosmetics.
  • Centella Asiatica Extractis listed in The List of Used Cosmetic Ingredient approved by the Ministry of Health of the People’s Republic of China in 2001.
  • Plalmed tested cytotoxicity assay of PMRepair®Centella, and the results showed that PMRepair® Centella based on keratin-forming cells does not show significant cytotoxicity in the range of 0.1563 mg/mL.

Package: Packed in aluminum foil bag, 1kg/bag.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

Q1: What quality certifications do your cosmetic ingredients hold?

A: To meet strict global standards and diverse market needs, our cosmetic ingredients are certified under major international systems:

ISO 9001:2015 (Quality Management System): Guarantees that our manufacturing processes—from raw material sourcing to final production—adhere to strict quality control standards. Ensures consistent batch-to-batch stability, which is essential for our clients in the Europe and US markets looking for premium, compliant, and reliable supply chains.

Halal Certification: Fully certified Halal, ensuring compliance with strict ingredient traceability and the absence of prohibited substances or cross-contamination.

Allows our partners to seamlessly enter and expand in the Southeast Asian (e.g., Indonesia, Malaysia) and Middle Eastern markets, meeting local regulatory mandates.

We are committed to providing fully traceable, high-quality, and compliant ingredients to support your brand’s global growth. If you need copies of our certificates or specific technical documentation (such as COA, MSDS, or compliance statements), please feel free to contact our team.

Q2: Are your active ingredients compliant with regulations in the EU, US, and South Korea?

A: Yes, absolutely. Regulatory compliance and safety are our top priorities. All of our premium active ingredients have standard, internationally recognized INCI names and are fully compliant with the stringent regulations of these major markets:

European Union: Fully compliant with the EU Cosmetic Regulation (EC) No 1223/2009, including safety assessments, and banned/restricted substance lists.

United States: Formulated and manufactured in strict accordance with FDA guidelines and the latest MoCRA (Modernization of Cosmetics Regulation Act) requirements, ensuring smooth product registration and listing.

South Korea: Compliant with the regulations set by the MFDS (Ministry of Food and Drug Safety), meeting their strict standards for functional cosmetic ingredients and efficacy documentation.

Whether you are a distributor or a brand owner in Europe, the Americas, or Southeast Asia, you can seamlessly integrate our ingredients into your formulations. We provide comprehensive regulatory support dossiers (COA, TDS, MSDS, and Composition Statements) to facilitate your local product promotion.

Q3: Do you provide clinical data to support the efficacy of your ingredients?

A: Yes, we provide comprehensive efficacy dossiers for all our flagship ingredients (such as PMSoothe® Kava97, PCR® Supermolecule Escin, and PMRefresh® Willow). Our data packages include:

In-vitro (cell-based) test reports to demonstrate cellular-level activihttphttp://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/ty and pathways.

In-vivo (human clinical) trial data to prove real-world visible results.

Safety assessments and clear Mechanism of Action (MOA) diagrams.

These rigorous, science-backed materials are designed to help our distributors easily convince formulation chemists and premium brand owners.

Q4: Can we request free samples for lab testing? Do you provide formulation support?

A: Absolutely. We support our partners’ R&D efforts through a two-step support system:

Free Samples: We provide complimentary samples for laboratory evaluation and pilot trials.

Technical & Formulation Support: To accelerate your application process, we will also provide formulation guides for you.

Our dedicated technical support team is also available to help your customers resolve challenges related to formulation stability, compatibility, and optimal dosage.

Q5: What marketing and sales support do you offer to international distributors?

A: We empower our global distributors with a comprehensive suite of “Turn-key” Marketing Kits to minimize your promotional costs and time-to-market. Our support includes:

Technial Documentation: Product brochures, white papers, and TDS, MSDS, and COA.

Visual Materials: Ingredient videos and ready-to-use social media posters.

Market Intelligence: Detailed competitive analysis reports and trend insights.

Co-Marketing: We also attend at major international cosmetics exhibitions to boost local brand awareness.

Q6: Do you pass customer leads or regional inquiries to your distributors?

A: Yes, we strictly adhere to a win-win, distributor-first channel policy:

Any direct inquiries, sample requests, or business leads received through our website or international trade shows from an authorized region will be precisely forwarded to our local exclusive or authorized distributor.

We protect your market efforts and actively help you convert local brand clients into long-term order.

Q7: What is the Minimum Order Quantity (MOQ) and lead time for international shipping?

A: We offer highly flexible logistical terms to support your business:

Minimum Order Quantity (MOQ): For most of our active ingredients, the MOQ is as low as 1 kg, allowing high flexibility for your inventory management.

Lead Time: Our standard lead time is highly competitive. Products are typically dispatched within 3 to 5 working days upon receipt of payment, subject to specific product availability and shipping logistics.

Q9: How to be Plamed’s exclusive distributor?

A: We maintain an open, strategic, and highly supportive attitude toward building exclusive global partnerships. We evaluate potential distributors based on:

Local distribution channels and market expertise.

Annual purchase volume projections.

Market expansion and promotional plans.

If you are interested in growing with us, please click the [Apply Now] to contact our business manager, and we will answer everything you would like to know.

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