Ethyl Ascorbic Acid

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Ethyl Ascorbic Acid

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Ethyl Ascorbic Acid is a vitamin C derivative obtained by hydrocarbylation. It is stable to light, heat, acid, alkali; and it is not easily oxidized by air. It is a chemically stable vitamin C derivative. Also it is soluble in water.

Ethyl Ascorbic Acid can block melanin formation by inhibiting tyrosinase activity. It has effect of whitening skin. Additionally, Ethyl Ascorbic Acid has strong antibacterial and anti-inflammatory effect. It can resist inflammation caused by sunlight. Meanwhile, it can improve the dullness of skin and repair skin cells. It promotes collagen production, and has antioxidant and anti-aging effect. Ethyl Ascorbic Acid has been widely used in whitening and anti-aging cosmetics.

Product Name CAS Number INCI Name
Ethyl Ascorbic Acid 86404-04-8 3-O-ETHYL ASCORBIC ACID
Molecular Weight Molecular Formula Molecular Structure
204.18g/mol C8H12O6
Product ID Specificcation Minimal Package Minimal Order Quantity
PMB2201 99% 1KG 1KG

Ethyl Ascorbic Acid is synthesized from vitamin C. The following are two common synthetic methods:

One-step synthesis Three-steps synthesis
Procedure Ethyl Ascorbic Acid is obtained by directly hydrolyzing 3-hydroxyl group using vitamin C and ethyl methanesulfonate or diethyl sulfate as raw materials. A series of reactions are carried out using vitamin C and acetone as raw materials and anhydrous copper sulfate as a catalyst to obtain Ethyl Ascorbic Acid.
Advantage Less steps, simple operation. Raw material is easy to get. Low cost, stable yield, high purity and easy to be industrialized.
Disadvantage Hydroxyl group is replaced by many positions; and the product is difficult to be separated. It needs to be purified by column chromatography and is not suitable for industrial production. /
Product Name Specification
Ethyl Ascorbic Acid 99%

 

Items Specification
Appearance White crystalline powder
Assay ≥99%
Physical Characteristics
pH value (3% water solution) 3.5–5.5
Free of VC ≤10ppm
Loss on drying ≤0.5%
Ignition residue ≤0.2%
Heavy Metals
Heavy Metals ≤10 ppm
As ≤2ppm

Vitamin C has four hydroxyl groups in its structure. It cannot be directly absorbed by skin; and it is easily oxidized to cause discoloration. As a whitening agent, it is limited in use of cosmetics. Vitamin C ethyl ether is prepared by 3-hydroxyl hydrocarbylation:

It is a vitamin C derivative that does not change color; and it does not affect its biological activity.

Compared with other vitamin C derivatives, Ethyl Ascorbic Acid has advantages in solubility and pH stability, as shown in the following tables:

Comparison of vitamin C content and solubility

Name Molecular weight Vitamin C
content (%)
Solubility
Ethyl Ascorbic Acid 204.18g/mol 86.3 Water-soluble
Ascorbic Acid 2-Glucoside 338.27g/mol 52.0 Water-soluble
Magnesium Ascorbyl Phosphate 303.5g/mol 49.3 Water-soluble
Sodium Ascorbyl Phosphate 358.08g/mol 46.55 Water-soluble

As can be seen from the above table, Ethyl Ascorbic Acid has the highest vitamin C content, and has the smallest molecular weight. It is more favorable to be absorbed by skin.

Comparison of pH stability

Name pH
Ethyl Ascorbic Acid 4.0-6.0
Ascorbic Acid 2-Glucoside 6.0-7.0
Magnesium Ascorbyl Phosphate 7.0-9.0
Sodium Ascorbyl Phosphate 8.0-10.0

Ethyl Ascorbic Acid is a relatively acidic substance compared to other vitamin C derivatives. It is more suitable for human skin property.

Ethyl Ascorbic Acid is easily decomposed by enzymes after being absorbed by skin. Thereby it plays the role of vitamin C in skin care:

  • Anti-aging

Ethyl Ascorbic Acid is effective against free radicals. It can resist damage caused by UVA and UVB. Ethyl Ascorbic Acid prevents skin cells from aging and damage. It can help body to reduce the harmful free radicals produced by metabolism, and effectively fight free radicals.

  • Skin-whitening

Ethyl Ascorbic Acid directly can reduce melanin to colorless reduced melanin. Then it exerts effect of whitening skin and lightening spots. It is also capable of reducing o-quinone by its own antioxidant activity; and it inhibits catalase activity to achieve the effect of inhibiting melanin formation.

  • Anti-inflammatory

Ethyl Ascorbic Acid promotes the synthesis and repair of collagen. It is effective against carbonation and saccharification. Thus it significantly resists inflammation on skin surface.

  • Promote collagen synthesis

Ethyl Ascorbic Acid has the activity of repairing collagen (including repairing the composition and synthesis of collagen). It can promote formation of skin cells and synthesis of collagen according to the ratio of skin cells and collagen consumption. Therefore, it makes skin shiny and elastic.

Ethyl Ascorbic Acid is widely used in whitening and anti-aging skin care products, such as lotion, cream, toner, mask, essence, etc. The recommended dosage in cosmetics is 0.5-3%.

Application Reference Dosage
Whitening 2%

Note:

  • When pH value of Ethyl Ascorbic Acid is 3.0-6.0, the whitening and freckling effect is the best.

Ethyl Ascorbic Acid application cases in major cosmetic brands in the world:

Country Brand Product
USA KIEHL‘S Corrective Dark Spot Solution

Corrective White Clarity Activating Toner

L’Oreal Turn-Around Anti-Spot Essence
GIORGIO ARMANI Crema Nera Extrema Reviving Cream
Australia Clorisland Pure Bright Radiant Essence Toner
China OSM Pearl Brightening Lotion

Pearl White Smoothing Lotion

Genuine Namir Snow Rose Crystal Whitening Essence
Beauty Plus VC Whitening Lotion
For Beloved One Melasleep Whitening Ethyl Ascorbic Acid Toner
Korea SULWHASOO Time-treasure Renovating Cream Ex
France Garnier Light Complete White Speed Super Essence
BIOTHERM White D-Tox CC Base Evenness SPF50+ PA++
LANCOME Absolute Precious Cells White Aura Serum

Blanc Expert Beautiful Skin Tone Brightening Cream

Japan SHISEIDO Anessa Perfect Uv Sunscreen A+

Cr Melanoreduce Cr

Shiseido White Lucent Luminizing Infuser

FANCL Whitening Essence

Whitening Mask

Dr.Ci.Labo O2 Herbal Gel Oxygen Charge
CLE DE PEAU Beaute Brightening Serum Supreme L
Thailand Beauty Buffet Whitening Body Lotion Co-Enzyme Q10

  • Sunscreen facial mask fluid
Ingredient Content (%) Ingredient Content (%)
Ethyl Ascorbic Acid 0.5 Hyaluronic Acid Oligomer 0.2
Butylene Glycol 3 Synthetic Egg White Powder 2
Aloe Extract 0.8 Scutellaria Baicalensis Extract 5
Propylene Glycol 0.5 Raspberry Ketone Glucoside 0.3
Glycerin 2 Macromolecular Hyaluronic Acid 0.3
Ginseng Extract 3 Liquorice Extract 3
Kojic Acid 0.8 Nano Titanium Dioxide 1.5
Water Add to 100

Preparation method

  1. Mix and dissolve ginseng extract, scutellaria baicalensis extract, and liquorice extract for 10-24 hours to obtain solution A.
  2. Mix propylene glycol with 1,2-butanediol to obtain solution B.
  3. Add hyaluronic acid oligomer, macromolecular hyaluronic acid, synthetic egg white powder, aloe extract, ethyl ascorbic acid to solution B. Disperse and mix by homogenizer to obtain solution C; dispersion speed of homogenizer is 10000 rpm; and for three times, each time is 5 seconds.
  4. Dissolve kojic acid, nano titanium dioxide, and raspberry ketone glucoside in one-third of water solution to obtain solution D.
  5. Add solution A to solution C, then add solution D, then add glycerin and the rest water to stir and dissolve. Stir in a homogenizer; disperse speed is 10,000 rpm. For three times, each time for 3 seconds. Then mask liquid is obtained.
  • Anti-aging emulsion
Phase Ingredient Content (%) Ingredient Content (%)
Oil phase Tocopherol Acetate 0.2 Methyl Glucose Sesquistearate 1.5
Kiwi Fruit Seed Oil 3 Flaxseed Oil 3
Geraniu Essential Oil 0.2 Bay Laurel Essential Oil 0.2
Cinnamon Essential Oil 0.2
Water phase Ethyl Ascorbic Acid 0.2 Troxerutin 0.2
Butanediol 10 Carbomer 0.15
Water Add to 100
Arginine 0.15 Solomonseal Rhizome P.E 0.5
Benincasae Semen P.E. 0.5

Preparation method

  1. The oil phase ingredients are heated to 70-90°C; stir and dissolve, and pressurize 0.1-10 MPa.
  2. The water phase ingredients are heated to 70-90°C; stir to dissolve, and pressurize 0.1-10Mpa.
  3. Inject the water phase into the oil phase mixture; homogenize for 3-5 minutes, then stir for 15 to 45 minutes. Release the pressure, and cool down to 45°C, and then add arginine, solomonseal rhizome P.E, benincasae semen P.E., and stir evenly.
  • Whitening essence
Phase Ingredient Content (%) Ingredient Content (%)
A Phase Sodium Hyaluronate 0.03 1,3-Butanediol 4
Propylene Glycol 3 Glycerin 3
Deionized Water Add to 100
B Phase Ethyl Ascorbic Acid 2
Fragrance q. s. Preservative q. s.

Preparation method

The phase A is heated to 85°C. Stir until completely dissolve, and cool down to below 45°C. Then add phase B. After dissolving completely, stop stirring. And then obtain the essence.

  • The CIR Expert Panel has experimentally concluded that Ethyl Ascorbic Acid is safe for use in cosmetics;
  • In 2010, the Department of Health announced that ethyl ascorbic acid is a whitening ingredient that can be added to cosmetics. The dosage limit is 1-2%.

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

Q1: What quality certifications do your cosmetic ingredients hold?

A: To meet strict global standards and diverse market needs, our cosmetic ingredients are certified under major international systems:

ISO 9001:2015 (Quality Management System): Guarantees that our manufacturing processes—from raw material sourcing to final production—adhere to strict quality control standards. Ensures consistent batch-to-batch stability, which is essential for our clients in the Europe and US markets looking for premium, compliant, and reliable supply chains.

Halal Certification: Fully certified Halal, ensuring compliance with strict ingredient traceability and the absence of prohibited substances or cross-contamination.

Allows our partners to seamlessly enter and expand in the Southeast Asian (e.g., Indonesia, Malaysia) and Middle Eastern markets, meeting local regulatory mandates.

We are committed to providing fully traceable, high-quality, and compliant ingredients to support your brand’s global growth. If you need copies of our certificates or specific technical documentation (such as COA, MSDS, or compliance statements), please feel free to contact our team.

Q2: Are your active ingredients compliant with regulations in the EU, US, and South Korea?

A: Yes, absolutely. Regulatory compliance and safety are our top priorities. All of our premium active ingredients have standard, internationally recognized INCI names and are fully compliant with the stringent regulations of these major markets:

European Union: Fully compliant with the EU Cosmetic Regulation (EC) No 1223/2009, including safety assessments, and banned/restricted substance lists.

United States: Formulated and manufactured in strict accordance with FDA guidelines and the latest MoCRA (Modernization of Cosmetics Regulation Act) requirements, ensuring smooth product registration and listing.

South Korea: Compliant with the regulations set by the MFDS (Ministry of Food and Drug Safety), meeting their strict standards for functional cosmetic ingredients and efficacy documentation.

Whether you are a distributor or a brand owner in Europe, the Americas, or Southeast Asia, you can seamlessly integrate our ingredients into your formulations. We provide comprehensive regulatory support dossiers (COA, TDS, MSDS, and Composition Statements) to facilitate your local product promotion.

Q3: Do you provide clinical data to support the efficacy of your ingredients?

A: Yes, we provide comprehensive efficacy dossiers for all our flagship ingredients (such as PMSoothe® Kava97, PCR® Supermolecule Escin, and PMRefresh® Willow). Our data packages include:

In-vitro (cell-based) test reports to demonstrate cellular-level activihttphttp://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/ty and pathways.

In-vivo (human clinical) trial data to prove real-world visible results.

Safety assessments and clear Mechanism of Action (MOA) diagrams.

These rigorous, science-backed materials are designed to help our distributors easily convince formulation chemists and premium brand owners.

Q4: Can we request free samples for lab testing? Do you provide formulation support?

A: Absolutely. We support our partners’ R&D efforts through a two-step support system:

Free Samples: We provide complimentary samples for laboratory evaluation and pilot trials.

Technical & Formulation Support: To accelerate your application process, we will also provide formulation guides for you.

Our dedicated technical support team is also available to help your customers resolve challenges related to formulation stability, compatibility, and optimal dosage.

Q5: What marketing and sales support do you offer to international distributors?

A: We empower our global distributors with a comprehensive suite of “Turn-key” Marketing Kits to minimize your promotional costs and time-to-market. Our support includes:

Technial Documentation: Product brochures, white papers, and TDS, MSDS, and COA.

Visual Materials: Ingredient videos and ready-to-use social media posters.

Market Intelligence: Detailed competitive analysis reports and trend insights.

Co-Marketing: We also attend at major international cosmetics exhibitions to boost local brand awareness.

Q6: Do you pass customer leads or regional inquiries to your distributors?

A: Yes, we strictly adhere to a win-win, distributor-first channel policy:

Any direct inquiries, sample requests, or business leads received through our website or international trade shows from an authorized region will be precisely forwarded to our local exclusive or authorized distributor.

We protect your market efforts and actively help you convert local brand clients into long-term order.

Q7: What is the Minimum Order Quantity (MOQ) and lead time for international shipping?

A: We offer highly flexible logistical terms to support your business:

Minimum Order Quantity (MOQ): For most of our active ingredients, the MOQ is as low as 1 kg, allowing high flexibility for your inventory management.

Lead Time: Our standard lead time is highly competitive. Products are typically dispatched within 3 to 5 working days upon receipt of payment, subject to specific product availability and shipping logistics.

Q9: How to be Plamed’s exclusive distributor?

A: We maintain an open, strategic, and highly supportive attitude toward building exclusive global partnerships. We evaluate potential distributors based on:

Local distribution channels and market expertise.

Annual purchase volume projections.

Market expansion and promotional plans.

If you are interested in growing with us, please click the [Apply Now] to contact our business manager, and we will answer everything you would like to know.

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