Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Paeoniflorin has great development prospect in market of cosmetic raw material, because of its various biological activities. Paeoniflorin is characterized by scavenging free radicals and resisting oxidative damage. It inhibits NF-kB cells and improves immune property of skin cells. It greatly exerts anti-inflammatory effect. Thus Paeoniflorin can be used in combination with other effective ingredients to treat skin sores, acne, pimple, sunburn and so on. Paeoniflorin inhibits melanin production due to its anti-oxidation and anti-inflammatory activities. It reduces skin pigmentation; and it has a non-dose-dependent whitening effect. In addition, Paeoniflorin can prevent and improve intrinsic skin aging and UV-induced skin aging. It has an anti-wrinkle effect.
| Product Name | CAS Number | INCI | |
| Paeonia Albiflora Extract | 23180-57-6 | PAEONIA ALBIFLORA ROOT EXTRACT | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| 480.45g/mol | C23H28O11 |  | |
| Product ID | Specification | Minimal Package | Minimal Order Quality |
| PMQD0601 | 50% | 1KG | 1KG |
| Items | Specification |
| Paeoniflorin | ≥50% HPLC |
| Organoleptic | |
| Appearance | Powder |
| Color | Off-white to light yellow |
| Odor | Characteristic |
| Physical Characteristics | |
| Moisture | ≤6.00% |
| Solubility | Soluble in water |
| Particle size | 100% through 80 mesh |
| Heavy Metals | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microbiological Tests | |
| Total plate count | ≤1000cfu/g |
| Yeast & mold count | ≤100cfu/g |
| Pseudomonas aeruginosa | Not detected |
| Staphylococcus aureus | Not detected |
| Heat-resistant escherichia coli | Not detected |
Paeoniflorin exerts an anti-inflammatory effect by inhibiting production of TNF-α and IL-1β and promoting expression of IL-10. The study result indicates that Paeoniflorin antagonizes chemokine formation induced by TNF-α and leukocyte migration. Therefore, Paeoniflorin shows a broad spectrum of anti-inflammatory property.
Paeoniflorin can enhance vitality and performance of skin cells. It promotes collagen fibers’ synthesis. Thereby Paeoniflorin contributes to increasing of toughness and elasticity of skin tissue; also it reduces production of lipid peroxides. Accordingly, Paeoniflorin significantly prevents intrinsic skin aging as well as DNA damage and skin wrinkling caused by UV. And compared with vitamin E, Paeoniflorin can better increase cell growth rate. Therefore, cosmetics containing Paeoniflorin are very effective anti-aging products.
| Cell | Treatment (M) | Cell growth rate | Cell mortality rate | Cell aging rate |
| keratinocytes | Blank | – | – | – |
| Paeoniflorin 0.0005M | 55.3% | 12.3% | 24.7% | |
| Vitamin E 0.0004M | 23.3% | 10.5% | 20.1% | |
| Fibroblast | Blank | – | – | – |
| Paeoniflorin 0.0005M | 18.4% | 11.5% | 17.2% | |
| Vitamin E 0.0004M | 9.96% | 15.4% | 22.8% |
| Test item | Concentration | Result |
| Elimination to hydroxyl radicals | 60.3μg/mL | Elimination rate：46.7% |
| Inhibition to cell apoptosis induced by hydrogen peroxide | 10μmol/L | Inhibition rate：40% |
| Inhibition to IL-2 production | 2.5g/kg | Inhibition rate：34.4% |
| Inhibition to IL-6 production | 2.5g/kg | Inhibition rate：24.8% |
| Inhibition to IL-10 production | 2.5g/kg | Inhibition rate：80.2% |
| Inhibition to MMP-9 activity | 0.01mmol/L | Inhibition rate：30.0% |
| Inhibition to NF-kB cell activity | 100μg/mL | Inhibition rate：53.2% |
Paeoniflorin is applied in cosmetics for treatment of acne and anti-inflammation including serum, cleanser, cream, emulsion, toner and so on.
| Application product | Recommended Dosage |
| Anti-wrinkle and anti-inflammation skin care products | 0.001-10% |
Paeoniflorin application cases in major cosmetic brands in the world
| Country | Brand | Product |
| Japan | IPSA | The Time Reset Aqua |
| Dr. Ci: Labo | Aqua-Collagen-Gel Super Sensitive O2 Herbal Gel Oxygen Charge | |
| Cle De Peau Beaute | The Serum Refreshing Cleansing Foam l | |
| Korea | SULWHASOO | Overnight Vitalizing Mask Essential Balancing Water Ex First Care Activating Serum Ex Evenfair Perfrcting Cushion No.1 Clarifying Mask |
| Whoo | Bichup Ja Saeng Essence Cheongidan Hwa Hyun Lotion | |
| AHC | Hydra B5 Lotion Premium Hydra B5 Sleeping Pack | |
| ReEn | Yungo the First Cleansing Treatment | |
| ACWELL | Aqua Clinity Cream | |
| China | Herborist | Whitening & Revitalizing Mask Whitening Toner T’ai Chi Detoxifying & Nutrient Clay |
| Inoherb | Rhodiola Fine Whitening & Anti-Oxidation Cleansing Foam | |
| You Yan | Balance Toner | |
| Carslan | BB Cushion |
Skin-care cream
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| A | Paeoniflorin | 4 | Pearl hydrolysate | 10 |
| Grape seed oil | 1.5 | β-glucan | 8 | |
| Bee pollen | 0.2 | Leucine | 2 | |
| Lysine | 2 | Aloe extract | 8 | |
| B | Span-60 | 2 | Tween-60 | 1 |
| Imidazolidinyl urea | 0.1 | |||
| C | Refined cottonseed oil | 7 | ||
| D | Fragrance | 0.4 | ||
| E | Octadecanol | 2 | Sorbitol Solution(70) | 3 |
| Deionized water | Add to 100 |
Cleanser
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| A | Paeoniflorin | 6 | Aloe extract | 10 |
| Pearl hydrolysate | 11 | Grape seed oil | 2 | |
| Β-glucan | 10 | Bee pollen | 1 | |
| Leucine | 2 | Lysine | 2 | |
| B | Octadecanol | 2 | Squalane | 3 |
| Self-emulsifying monoglycerin stearate | 1 | |||
| C | C9-10 Decyl glucoside | 20 | Deionized water | Add to 100 |
Skin-care lotion
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| A | Paeoniflorin | 5 | Aloe extract | 10 |
| Pearl hydrolysate | 12 | Grape seed oil | 2 | |
| Β-glucan | 8 | Bee pollen | 0.2 | |
| Leucine | 2 | Lysine | 2 | |
| Citric acid | 1 | |||
| B | Fragrance | 0.2 | Cetanol | 3 |
| C | Lanolin | 4 | Glycerin monostearate | 3 |
| Glycerin | 2.5 | Isopropyl myristate | 2 | |
| Triethanolamine | 1 | Stearic acid | 2 | |
| Methylparaben | 0.2 | Deionized water | Add to 100 |
Toner
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| A | Paeoniflorin | 5 | Aloe extract | 12 |
| Pearl hydrolysate | 12 | Grape seed oil | 2 | |
| Β-glucan | 5 | Bee pollen | 0.2 | |
| Leucine | 1 | Lysine | 1 | |
| Citric acid | 1 | |||
| B | Stearic acid | 3 | Emulsifier | 3 |
| Deionized water | Add to 100 |
Cream
| Ingredient | Content (%) | Ingredient | Content (%) |
| Paeoniflorin | 0.5 | Stearic acid | 1.0 |
| Cetanol | 2.0 | PEG-20 | 1.0 |
| Sorbitan monostearate | 1.0 | Mineral oil | 10.0 |
| Tricaprylin | 5.0 | Triethanolamine | 0.5 |
| Carbomer | 0.2 | Glycerin | 5.0 |
| Propylene glycol | 3.0 | Preservative | Appropriate |
| Fragrance | Appropriate | Purified water | Add to 100 |
Essence
| Ingredient | Content (%) | Ingredient | Content (%) |
| Paeoniflorin | 1 | Propylene glycol | 10.0 |
| Glycerin | 10.0 | Sodium hyaluronate solution (1%) | 5.0 |
| Ethanol | 5.0 | Castor oil | 1.0 |
| Methyl 4-hydroxybenzoate | 0.1 | 0.3 | |
| Triethanolamine | 0.4 | Fragrance | Appropriate |
| Purified water | Add to 100 |
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
