Package: 10g bottle packaging, with a sterile aluminum foil seal inside the bottle mouth.
Storage: Store in cool and dry place at temperature 2 to 8℃, keep away from strong light.
Use it as soon as possible after unpacking.
Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Acetyl Hexapeptide-8, also known as hexapeptide, is a bioactive peptide that mimics the mechanism of botulinum toxin and belongs to the class of neurotransmitter-inhibiting peptides. The current preparation of cosmetic-grade Acetyl Hexapeptide-8 primarily relies on chemical synthesis. Plamed uses the industry standard Solid Phase Peptide Synthesis (SPPS) method to produce this raw material, enabling stable manufacturing of cosmetic-grade ingredients with ≥99.0% purity. The product features a single configuration, controllable impurities, and strong batch consistency, combining high efficacy with cost-effectiveness. Core bioactivity of Acetyl Hexapeptide-8: competitively inhibits the binding of presynaptic membrane SNAP-25 protein to synaptic vesicle proteins, blocking acetylcholine neurotransmission to reduce excessive muscle contraction. Simultaneously it can promote fibroblast proliferation, enhancing collagen and elastin synthesis capacity. Thus, it offers skincare benefits including reducing dynamic wrinkles, improving static wrinkles, firming and anti-aging effects, and soothing the skin. Cosmetics formulating this ingredient can improve facial expression lines, periorbital fine lines, and skin laxity, restore smoothness and firmness. It is widely used in anti-aging, firming, and wrinkle-reducing cosmetics.
| Product Name | CAS Number | INCI Name | |
| Acetyl Hexapeptide-8 | 616204-22-9 | ACETYL HEXAPEPTIDE-8 | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| C34H60N14O12S | 888.99g/mol |  |
|
| Product ID | Specification | Minimal Package | MOQ |
| PMKZ2701 | Purity≥99.0% | 10g | 10g |
Acetyl Hexapeptide-8 is prepared through chemical synthesis, which primarily encompasses two methods: solid-phase peptide synthesis (SPPS) and liquid-phase peptide synthesis (LPPS). Plamed employs solid-phase peptide synthesis (SPPS) technology to provide customers with raw materials characterized by high purity, consistent batch stability, and suitability for large-scale production.
| Source of chemical synthesis | ||
| Methods | Solid-phase peptide synthesis | Liquid-phase peptide synthesis method |
| Flow chart | Raw materials—synthesis—purification—drying—package | The final product is obtained through a pure liquid-phase reaction environment, involving multi-step amino acid coupling, deprotection, stepwise extraction and purification, and freeze-drying refinement. |
| Advantages | High purity (≥99.0%), free of animal-derived components, good batch consistency, and easy for quality control | Low cost of raw material, and the good flexibility of small-batch customized, making it suitable for the synthesis of short peptides and small molecule fragments. |
| Disadvantages | The synthesis cost is relatively high and the technical requirements are strict. | The synthesis process is cumbersome, purity control is difficult, and the cost of large-scale mass production is high. |
| TEST ITEMS | SPECIFICATION |
| Purity | ≥99.0% HPLC |
| Peptide content | ≥85.0% HPLC |
| Acetic acid content | ≤5.0% |
| Organoleptic | |
| Appearance | Powder |
| Color | White to off-white |
| Odor | Characteristic |
| Physical Characteristics | |
| Water content | ≤5.0% |
| Solubility | ≥100 mg/mL (H2O) |
| Heavy Metal | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microorganism Test | |
| Total plate count | ≤1000cfu/g |
| Yeast & mold count | ≤100cfu/g |
Acetyl Hexapeptide-8, as a botulinum toxin-like active peptide, competitively binds to the SNAP-25 protein on the presynaptic membrane. Then it blocks the fusion of synaptic vesicles with the cell membrane, inhibiting the release of acetylcholine. Consequently, it reduces excessive contraction of facial muscles, thereby diminishing dynamic expression lines such as forehead wrinkles, crow’s feet, and glabellar lines at their source. Plamed’s test has proved that at a concentration of 0.002%, Acetyl Hexapeptide-8 exhibits significant inhibition of acetylcholine content, with an inhibition rate of 20.58%. It simultaneously suppresses catecholamine release, reduces muscle contraction frequency, and delays the formation of new expression lines.
Acetyl Hexapeptide-8 promotes the proliferation and differentiation of skin fibroblasts, upregulating the gene expression of Type I collagen, Type III collagen, and elastin. Research confirms this ingredient reverses UV-induced photoaging-related collagen loss in fibroblasts in a dose-dependent manner. It enhances dermal extracellular matrix synthesis, increases dermal thickness, improves skin laxity and dryness, fills static wrinkle depressions, and restores skin firmness and elasticity.
Acetyl Hexapeptide-8 inhibits the release of inflammatory factors IL-6 and TNF-α, reducing skin inflammatory responses and alleviating redness and sensitivity caused by external irritants. Studies indicate that in LPS-induced macrophage inflammation models, Acetyl Hexapeptide-8 achieved maximum inhibition rates of 42.3% and 38.7% for inflammatory factors at concentrations of 0.01–0.1 mmol/L. It also promotes keratinocyte proliferation, accelerates stratum corneum barrier repair, and enhances skin moisture retention and resilience. As a small-molecule peptide, it exhibits excellent skin compatibility. The high-purity product, manufactured via SPPS technology, is free from irritating impurities, making it suitable for anti-aging needs in sensitive skin.
Acetyl Hexapeptide-8 exhibits exceptional transdermal absorption capabilities, delivering noticeable wrinkle-reducing and firming effects even at low concentrations. Widely formulated into anti-aging serums, wrinkle-fighting creams, firming lotions, eye serums/creams, neck creams, and masks, it stands as a core active ingredient in premium anti-aging skincare products.
It synergistically enhances the efficacy of ingredients like sodium hyaluronate, collagen, and Hydroxypropyl Tetrahydropyrantriol, delivering comprehensive anti-aging benefits.
| Product | Reference Dosage |
| Acetyl Hexapeptide-8 (99% purity) | 0.005-0.1% |
Notes:
Acetyl Hexapeptide-8 application cases in major cosmetic brands in the world:
| Country | Brand | Product |
| China | PROYA | Advanced Firming Nourishing Essence |
| CHANDO | Time Frozen Aging Resistance Activating Essence Cream | |
| Canada | The Ordinary | Multi-Peptide High-Concentration Anti-Aging Repair Essence |
| USA | Skin Ceuticals | Tripeptide-R Neck Repair |
| Estée Lauder | Advanced Night Repair Eye Supercharged Gel-Creme Synchronized Multi-Recovery
Perfectionist Pro Rapid Firming + Lift Treatment Cream |
|
| France | L’Oréal Paris | Age Perfect Nectar Royal Collagen Moisturizing Cream |
Package: 10g bottle packaging, with a sterile aluminum foil seal inside the bottle mouth.
Storage: Store in cool and dry place at temperature 2 to 8℃, keep away from strong light.
Use it as soon as possible after unpacking.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional Acetyl Hexapeptide-8 manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Acetyl Hexapeptide-8 and good Acetyl Hexapeptide-8 price will help customers make good terminal products and help customers win a lasting and broad market.
A: To meet strict global standards and diverse market needs, our cosmetic ingredients are certified under major international systems:
ISO 9001:2015 (Quality Management System): Guarantees that our manufacturing processes—from raw material sourcing to final production—adhere to strict quality control standards. Ensures consistent batch-to-batch stability, which is essential for our clients in the Europe and US markets looking for premium, compliant, and reliable supply chains.
Halal Certification: Fully certified Halal, ensuring compliance with strict ingredient traceability and the absence of prohibited substances or cross-contamination.
Allows our partners to seamlessly enter and expand in the Southeast Asian (e.g., Indonesia, Malaysia) and Middle Eastern markets, meeting local regulatory mandates.
We are committed to providing fully traceable, high-quality, and compliant ingredients to support your brand’s global growth. If you need copies of our certificates or specific technical documentation (such as COA, MSDS, or compliance statements), please feel free to contact our team.
A: Yes, absolutely. Regulatory compliance and safety are our top priorities. All of our premium active ingredients have standard, internationally recognized INCI names and are fully compliant with the stringent regulations of these major markets:
European Union: Fully compliant with the EU Cosmetic Regulation (EC) No 1223/2009, including safety assessments, and banned/restricted substance lists.
United States: Formulated and manufactured in strict accordance with FDA guidelines and the latest MoCRA (Modernization of Cosmetics Regulation Act) requirements, ensuring smooth product registration and listing.
South Korea: Compliant with the regulations set by the MFDS (Ministry of Food and Drug Safety), meeting their strict standards for functional cosmetic ingredients and efficacy documentation.
Whether you are a distributor or a brand owner in Europe, the Americas, or Southeast Asia, you can seamlessly integrate our ingredients into your formulations. We provide comprehensive regulatory support dossiers (COA, TDS, MSDS, and Composition Statements) to facilitate your local product promotion.
A: Yes, we provide comprehensive efficacy dossiers for all our flagship ingredients (such as PMSoothe® Kava97, PCR® Supermolecule Escin, and PMRefresh® Willow). Our data packages include:
In-vitro (cell-based) test reports to demonstrate cellular-level activihttphttp://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/ty and pathways.
In-vivo (human clinical) trial data to prove real-world visible results.
Safety assessments and clear Mechanism of Action (MOA) diagrams.
These rigorous, science-backed materials are designed to help our distributors easily convince formulation chemists and premium brand owners.
A: Absolutely. We support our partners’ R&D efforts through a two-step support system:
Free Samples: We provide complimentary samples for laboratory evaluation and pilot trials.
Technical & Formulation Support: To accelerate your application process, we will also provide formulation guides for you.
Our dedicated technical support team is also available to help your customers resolve challenges related to formulation stability, compatibility, and optimal dosage.
A: We empower our global distributors with a comprehensive suite of “Turn-key” Marketing Kits to minimize your promotional costs and time-to-market. Our support includes:
Technial Documentation: Product brochures, white papers, and TDS, MSDS, and COA.
Visual Materials: Ingredient videos and ready-to-use social media posters.
Market Intelligence: Detailed competitive analysis reports and trend insights.
Co-Marketing: We also attend at major international cosmetics exhibitions to boost local brand awareness.
A: Yes, we strictly adhere to a win-win, distributor-first channel policy:
Any direct inquiries, sample requests, or business leads received through our website or international trade shows from an authorized region will be precisely forwarded to our local exclusive or authorized distributor.
We protect your market efforts and actively help you convert local brand clients into long-term order.
A: We offer highly flexible logistical terms to support your business:
Minimum Order Quantity (MOQ): For most of our active ingredients, the MOQ is as low as 1 kg, allowing high flexibility for your inventory management.
Lead Time: Our standard lead time is highly competitive. Products are typically dispatched within 3 to 5 working days upon receipt of payment, subject to specific product availability and shipping logistics.
A: We maintain an open, strategic, and highly supportive attitude toward building exclusive global partnerships. We evaluate potential distributors based on:
Local distribution channels and market expertise.
Annual purchase volume projections.
Market expansion and promotional plans.
If you are interested in growing with us, please click the [Apply Now] to contact our business manager, and we will answer everything you would like to know.
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