Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.

Ethyl Ascorbic Acid is a premium active ingredient series developed by Plamed Green Science Group. Derived from natural botanical sources, the products are standardized for highly purified actives and designed to target specific skincare concerns through advanced formulation science.

Ethyl Ascorbic Acid can block melanin formation by inhibiting tyrosinase activity. It has effect of whitening skin. Additionally, Ethyl Ascorbic Acid has strong antibacterial and anti-inflammatory effect. It can resist inflammation caused by sunlight. Meanwhile, it can improve the dullness of skin and repair skin cells. It promotes collagen production, and has antioxidant and anti-aging effect. Ethyl Ascorbic Acid has been widely used in whitening and anti-aging cosmetics.
| Product Name | CAS Number | INCI Name | |
| Ethyl Ascorbic Acid | 86404-04-8 | 3-O-ETHYL ASCORBIC ACID | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| 204.18g/mol | C8H12O6 | ![]() | |
| Product ID | Specificcation | Minimal Package | Minimal Order Quantity |
| PMB2201 | 99% | 1KG | 1KG |
Ethyl Ascorbic Acid is synthesized from vitamin C. The following are two common synthetic methods:
| One-step synthesis | Three-steps synthesis | |
| Procedure | Ethyl Ascorbic Acid is obtained by directly hydrolyzing 3-hydroxyl group using vitamin C and ethyl methanesulfonate or diethyl sulfate as raw materials. | A series of reactions are carried out using vitamin C and acetone as raw materials and anhydrous copper sulfate as a catalyst to obtain Ethyl Ascorbic Acid. |
| Advantage | Less steps, simple operation. | Raw material is easy to get. Low cost, stable yield, high purity and easy to be industrialized. |
| Disadvantage | Hydroxyl group is replaced by many positions; and the product is difficult to be separated. It needs to be purified by column chromatography and is not suitable for industrial production. | / |
| Product Name | Specification |
| Ethyl Ascorbic Acid | 99% |
| Items | Specification |
| Appearance | White crystalline powder |
| Assay | ≥99% |
| Physical Characteristics | |
| pH value (3% water solution) | 3.5–5.5 |
| Free of VC | ≤10ppm |
| Loss on drying | ≤0.5% |
| Ignition residue | ≤0.2% |
| Heavy Metals | |
| Heavy Metals | ≤10 ppm |
| As | ≤2ppm |
Vitamin C has four hydroxyl groups in its structure. It cannot be directly absorbed by skin; and it is easily oxidized to cause discoloration. As a whitening agent, it is limited in use of cosmetics. Vitamin C ethyl ether is prepared by 3-hydroxyl hydrocarbylation:
It is a vitamin C derivative that does not change color; and it does not affect its biological activity.
Compared with other vitamin C derivatives, Ethyl Ascorbic Acid has advantages in solubility and pH stability, as shown in the following tables:
Comparison of vitamin C content and solubility
| Name | Molecular weight | Vitamin C content (%) | Solubility |
| Ethyl Ascorbic Acid | 204.18g/mol | 86.3 | Water-soluble |
| Ascorbic Acid 2-Glucoside | 338.27g/mol | 52.0 | Water-soluble |
| Magnesium Ascorbyl Phosphate | 303.5g/mol | 49.3 | Water-soluble |
| Sodium Ascorbyl Phosphate | 358.08g/mol | 46.55 | Water-soluble |
As can be seen from the above table, Ethyl Ascorbic Acid has the highest vitamin C content, and has the smallest molecular weight. It is more favorable to be absorbed by skin.
Comparison of pH stability
| Name | pH |
| Ethyl Ascorbic Acid | 4.0-6.0 |
| Ascorbic Acid 2-Glucoside | 6.0-7.0 |
| Magnesium Ascorbyl Phosphate | 7.0-9.0 |
| Sodium Ascorbyl Phosphate | 8.0-10.0 |
Ethyl Ascorbic Acid is a relatively acidic substance compared to other vitamin C derivatives. It is more suitable for human skin property.
Ethyl Ascorbic Acid is easily decomposed by enzymes after being absorbed by skin. Thereby it plays the role of vitamin C in skin care:
Ethyl Ascorbic Acid is effective against free radicals. It can resist damage caused by UVA and UVB. Ethyl Ascorbic Acid prevents skin cells from aging and damage. It can help body to reduce the harmful free radicals produced by metabolism, and effectively fight free radicals.
Ethyl Ascorbic Acid directly can reduce melanin to colorless reduced melanin. Then it exerts effect of whitening skin and lightening spots. It is also capable of reducing o-quinone by its own antioxidant activity; and it inhibits catalase activity to achieve the effect of inhibiting melanin formation.

Ethyl Ascorbic Acid promotes the synthesis and repair of collagen. It is effective against carbonation and saccharification. Thus it significantly resists inflammation on skin surface.
Ethyl Ascorbic Acid has the activity of repairing collagen (including repairing the composition and synthesis of collagen). It can promote formation of skin cells and synthesis of collagen according to the ratio of skin cells and collagen consumption. Therefore, it makes skin shiny and elastic.

Ethyl Ascorbic Acid is widely used in whitening and anti-aging skin care products, such as lotion, cream, toner, mask, essence, etc. The recommended dosage in cosmetics is 0.5-3%.
| Application | Reference Dosage |
| Whitening | 2% |
Note:
Ethyl Ascorbic Acid application cases in major cosmetic brands in the world:
| Country | Brand | Product |
| USA | KIEHL‘S | Corrective Dark Spot Solution Corrective White Clarity Activating Toner |
| L’Oreal | Turn-Around Anti-Spot Essence | |
| GIORGIO ARMANI | Crema Nera Extrema Reviving Cream | |
| Australia | Clorisland | Pure Bright Radiant Essence Toner |
| China | OSM | Pearl Brightening Lotion Pearl White Smoothing Lotion |
| Genuine Namir | Snow Rose Crystal Whitening Essence | |
| Beauty Plus | VC Whitening Lotion | |
| For Beloved One | Melasleep Whitening Ethyl Ascorbic Acid Toner | |
| Korea | SULWHASOO | Time-treasure Renovating Cream Ex |
| France | Garnier | Light Complete White Speed Super Essence |
| BIOTHERM | White D-Tox CC Base Evenness SPF50+ PA++ | |
| LANCOME | Absolute Precious Cells White Aura Serum Blanc Expert Beautiful Skin Tone Brightening Cream | |
| Japan | SHISEIDO | Anessa Perfect Uv Sunscreen A+ Cr Melanoreduce Cr Shiseido White Lucent Luminizing Infuser |
| FANCL | Whitening Essence Whitening Mask | |
| Dr.Ci.Labo | O2 Herbal Gel Oxygen Charge | |
| CLE DE PEAU | Beaute Brightening Serum Supreme L | |
| Thailand | Beauty Buffet | Whitening Body Lotion Co-Enzyme Q10 |

| Ingredient | Content (%) | Ingredient | Content (%) |
| Ethyl Ascorbic Acid | 0.5 | Hyaluronic Acid Oligomer | 0.2 |
| Butylene Glycol | 3 | Synthetic Egg White Powder | 2 |
| Aloe Extract | 0.8 | Scutellaria Baicalensis Extract | 5 |
| Propylene Glycol | 0.5 | Raspberry Ketone Glucoside | 0.3 |
| Glycerin | 2 | Macromolecular Hyaluronic Acid | 0.3 |
| Ginseng Extract | 3 | Liquorice Extract | 3 |
| Kojic Acid | 0.8 | Nano Titanium Dioxide | 1.5 |
| Water | Add to 100 |
Preparation method:
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| Oil phase | Tocopherol Acetate | 0.2 | Methyl Glucose Sesquistearate | 1.5 |
| Kiwi Fruit Seed Oil | 3 | Flaxseed Oil | 3 | |
| Geraniu Essential Oil | 0.2 | Bay Laurel Essential Oil | 0.2 | |
| Cinnamon Essential Oil | 0.2 | |||
| Water phase | Ethyl Ascorbic Acid | 0.2 | Troxerutin | 0.2 |
| Butanediol | 10 | Carbomer | 0.15 | |
| Water | Add to 100 | |||
| Arginine | 0.15 | Solomonseal Rhizome P.E | 0.5 | |
| Benincasae Semen P.E. | 0.5 |
Preparation method:
| Phase | Ingredient | Content (%) | Ingredient | Content (%) |
| A Phase | Sodium Hyaluronate | 0.03 | 1,3-Butanediol | 4 |
| Propylene Glycol | 3 | Glycerin | 3 | |
| Deionized Water | Add to 100 | |||
| B Phase | Ethyl Ascorbic Acid | 2 | ||
| Fragrance | q. s. | Preservative | q. s. |
Preparation method:
The phase A is heated to 85°C. Stir until completely dissolve, and cool down to below 45°C. Then add phase B. After dissolving completely, stop stirring. And then obtain the essence.
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.