Whitening Toner:
Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Glutathione (GSH), also named Reduced Glutathione, is a tripeptide composed of glutamate, cysteine, and glycine. It can be found in almost every cell of human body. Nowadays, the industrial production of Glutathione is mainly obtained by enzymatic synthesis. In the method, Glutathione has a high purity and good water-solubility. As an active tripeptide with important physiological functions, Glutathione is the most important non-protein sulfhydryl compound in organisms. It has biological activities such as detoxification, anti-oxidation, free radical scavenging, skin-whitening and spot-fading. Therefore, it is widely used in cosmetics, medicine, health care products and other industries. It can be soluble in water greatly and easy to be added into all kinds of skin-whitening cosmetics. Plamed Glutathione is divided into cosmetics grade and medical grade.
| Product Name | CAS Number | INCI Name | |
| Glutathione | 70-18-8 | Glutathione | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| 307.32g/mol | C10H17N3O6S |  | |
| Product ID | Specificcation | Minimal Package | Minimal Order Quantity |
| PMB1603 | 98% | 1KG | 1KG |
There are four main methods of preparing Glutathione: enzymatic synthesis, solvent extraction, chemical synthesis and fermentation. Plamed produces Glutathione by enzymatic synthesis. And the product is of high purity and less pollution to environment. It has a good performance-price ratio.
| Method | Raw material | Operation | Purity | Pollution |
| Enzymatic synthesis | Use L-glutamic acid, L-cysteine and glycine as substrate, and use the natural glutathione synthetase of organisms, then add a little ATP/ADP to synthesize Glutathione | Fast reaction speed, high sensitivity, clear process, but high cost. | High | Low |
| Solvent extraction | Use wheat germ and yeast as raw materials, and then separate and purify to produce Glutathione. | Backward technology, small production scale, low output, low cost. | Higher than that of enzymatic synthesis. | Low |
| Chemical synthesis | Use glutamic acid, cysteine and glycine as raw materials to synthesize Glutathione | Many reaction steps, long reaction time, complex operation and high cost. | Low | Severe |
| Fermentation | Use cheap carbohydrates as raw materials, then convert the materials into glutathione by the metabolism of substances in specific microorganisms | Mild reaction conditions, fast production speed, low cost. | Not high | Low |
| Reduced Glutathione (GSH) | Glutathione Disulfide (GSSG) | |
| State | Active state | Inactive state |
| Percentage of glutathione | More than 95% | 1% or so |
| Function | Free radical scavenging, anti-aging, skin-whitening | / |
| Application | Whitening and antioxidant cosmetics | / |
| Relation | Reduced Glutathione can convert into GSSG. GSSG’s physiological activity is very low and has little effect, because it accounts for a small proportion. So Glutathione is usually called Reduced Glutathione, and it plays a main role. | |
| Product Name | Specification | Color |
| Glutathione | 98% HPLC | White powder |
| Items | Specifications |
| Assay | ≥98% HPLC |
| Appearance | White or off-white powder |
| Related substances | GSSG≤1.5% |
| Chlorides | ≤200ppm |
| Sulfates | ≤200ppm |
| Ammonium | ≤200ppm |
| Physical Characteristics | |
| Loss on drying | ≤0.5% |
| Residue on ignition | ≤0.1% |
| Specific rotation | -15.5°～-17.5° |
| Heavy Metals | |
| Heavy metals | ≤10ppm |
| Iron | ≤10ppm |
Glutathione can chelate internal and external toxins such as heavy metals. It can prevent skin pigmentation. Also it can inhibit the formation of new melanin and reduce its oxidation. Glutathione alleviates skin problems such as chloasma. It has a great function of lightening skin and removing freckles. Meanwhile, Glutathione is small molecular peptide. So it can easily penetrate cell membrane and be absorbed by the skin, when applied externally. It is an effective cosmetic ingredient for whitening skin
Glutathione’s structure contains a lively thiol group-SH. So it is easily oxidized and dehydrogenated. The free radicals can be reduced directly into acidic substances by combining the thiol group with free radicals in the body. Thereby it accelerates the elimination of the free radicals; and fight against free radical damage to the skin. At the same time, Glutathione is a kind of radiation protective agent. It can enable radiation to produce highly active free radicals in living organisms through direct and indirect action. And then Glutathione can clear away these free radicals to achieve its anti-oxidant effect.
Glutathione can isolate the damage of PM2.5 to the skin, when acting on the skin surface.
| Test Items | Concentration | Result |
| Elimination of free radical DPPH | 0.1% | Elimination rate：65% |
| Removal rate of superoxide radical | 1.0% | Elimination rate：23.1% |
| Inhibition of lipid peroxidation | 0.1% | Inhibition rate：40% |
| Inhibition of protein damage under UVA | 1mmol/l | Inhibition rate：79.7% |
| Inhibition of hyaluronic acid decrease | 1% | Inhibition rate：57.4% |
| Inhibition of the activity of B-16 melanocytes | 0.1mg/ml | Inhibition rate：57.1% |
| Inhibition of tyrosinase activity | 0.1mg/ml | Inhibition rate：83.5% |
Glutathione is mainly used in whitening skin care products, such as serum, facial mask, emulsion, toner, essence, cream, etc.
| Product | Reference Dosage |
| Glutathione 98% | 0.1-0.5% |
Attention:
Glutathione application cases in major cosmetic brands in the world:
| Country | Brand | Product |
| Korea | Cindella | Cindeltox white cream |
| Secret key | Snow White Cream | |
| Dr. Althea | Power Whitening Glutathione Cream | |
| Claires | Guerisson 9 Complex, Essence | |
| G9skin | White In Milk Whipping Foam, cream , eye cream，sun, serum | |
| Wishtrend | Hours-Long Moisturizing Gauze Sheet Mask | |
| Papa Recipe | Bombee Whitening Honey Mask Pack | |
| Klavuu | Marine Collagen Micro Cleansing Water | |
| USA | Relumins | Glutathione toner, essence, body whitening cream |
| Kirkman | Reduced L-Glutathione Lotion | |
| Swanson | L-Glutathione Cream with Setria | |
| BeShiny | Glutathione Skin Whitening Brightening Serum | |
| Thailand | Mistine | Intensive Whitening Facial Cream, utathione Intensive Whitening Serum |
| Shouvy | Whitening Body Lotion, ening Bleaching Soap | |
| Cathy Doll Karmart | L-glutathione Magic sunscreen | |
| France | ATrue | Watery Calming Cream |
Whitening Toner:
| Ingredient | Content (Mass) | Ingredient | Content (Mass) |
| Glutathione | 54 | Aloe Vera Extract | 54 |
| Papaya extract | 50 | Sesame oil | 54 |
| Paeoniflorin | 50 | Shea butter | 54 |
| Tetrahydrocurcumin | 50 | Vitamin C | 56 |
| Black bean estroge | 50 | Blackberrglily Rhizome Extract | 54 |
| Lubrajel oil | 50 | Ophiopogonis japonicus P.E | 50 |
| D- panthenol | 50 | 1,2- octylene glycol | 54 |
| Guar gum | 52 | Nigella damascena extract | 54 |
| Cocoa butter | 54 | Sorbitan octanoate | 50 |
| Codium tomentosum extract | 50 | Water | 2000 |
Anti-spot Lotion:
| Ingredient | Content（%） | Ingredient | Content（%） |
| Glutathione | 0.5 | Phosphoric acid cetyl ester diethanolamine | 2.0 |
| EGMS | 12.0 | Catechol | 2.0 |
| Isopropyl palmitate | 12.0 | Ascorbyl palmitate | 0.2 |
| 2- 16/18 glycol | 2.0 | Acetic acid | 0.2 |
| Vaseline | 2.5 | Methoxycinnamate | 1.0 |
| Lanonol | 3.0 | Butyl methoxydibenzoyl methane | 1.0 |
| Propylparaben | 0.1 | 2-methyl5-chloroisothiazolone | 0.05 |
| BHA | 0.2 | Imidazolidinyl urea | 0.1 |
| BHT | 0.3 | Parsol 1789 | 1.0 |
| Cysteine | 0.5 | Fragrance | 0.6 |
| Refined water | Add to 100 | ||
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents
