Resveratrol – Natural Antioxidant from Polygonum Cuspidatum
Natural resveratrol powder in 98% and 10% water-soluble grades — no synthetic resveratrol added, whiter colour, higher activity, better overall cost.
Resveratrol
Resveratrol is a natural antioxidant active derived from Polygonum cuspidatum (Japanese knotweed). It helps protect against oxidative stress, combat visible signs of skin aging, and improve dull-looking skin, making it suitable for anti-aging, brightening, and protective skincare formulations.
Plamed offers naturally sourced Resveratrol without synthetic resveratrol, in two specifications: 98% high-purity Resveratrol and 10% water-soluble Resveratrol. Through process optimization, Plamed delivers enhanced activity, improved color appearance, and greater overall cost efficiency.
Resveratrol: A Natural Antioxidant Active from Polygonum Cuspidatum
Resveratrol is a natural plant polyphenol and a well-studied antioxidant active ingredient. Plamed supplies high quality resveratrol extract powder with resveratrol ingredients meeting INCI RESVERATROL; the resveratrol active ingredient is standardized at 98% or 10% water-soluble. It is widely found in nature — natural sources of resveratrol include hellebore, Polygonum cuspidatum, grape, peanut and pineapple. Plamed resveratrol is extracted from the root of Polygonum cuspidatum, a natural cosmetic raw material listed as INCI RESVERATROL.
Items | Details |
Product Name | Resveratrol |
CAS Number | 501-36-0 |
INCI Name | RESVERATROL |
Molecular Formula | C14H12O3 |
Molecular Weight | 228.24 g/mol |
Molecular Structure | trans-stilbene skeleton |
Product ID / Specification | PMB0501 98% / PMB0502 10% water-soluble |
Minimal Package / MOQ | 1 kg / 1 kg |
Structure of Resveratrol
The structure of resveratrol is a trans-stilbene skeleton: two phenolic rings joined by an ethylene bridge, carrying three hydroxyl groups (3, 5, 4′-trihydroxystilbene, C14H12O3, 228.24 g/mol). The polyphenolic architecture drives its free-radical-scavenging behaviour, and an octanol/water partition coefficient (log Pow) of 2.8 (MSDS) places it among the lipophilic polyphenols — the reason Plamed also offers a 10% water-soluble grade for clear water-based formulas.
Resveratrol Source: Polygonum Cuspidatum
Polygonum cuspidatum resveratrol — resveratrol from Polygonum cuspidatum root — is the marker active of this plant. The resveratrol source is the dried root of Polygonum cuspidatum, botanically also described as Reynoutria japonica Houtt. (Japanese knotweed), a perennial herbaceous plant native to east Asia and now widely distributed throughout China, mainly in the northwest, north and south. The dried root is a traditional Chinese medicine containing emodin and resveratrol among its active constituents, which is why Polygonum cuspidatum extract is widely used beyond cosmetics.
Resveratrol Manufacturing Route
The 98% grade is produced through a fourteen-step purification route: root pretreatment (fermentation), ethyl acetate extraction, concentration, ethanol impurity removal, centrifugation, compression, drying, ethanol dissolution, decoloring by alumina and carbon, crystallization in 95% ethanol, a second centrifugation and final drying.
Why Plamed Resveratrol
· Natural source, no synthetic addition. Our natural 98% grade contains no synthetic blending; the natural extract shows higher activity.
· Process upgraded many times, giving Plamed resveratrol a cost advantage at comparable purity.
· Whiter colour — the whiter powder is more suitable for cosmetic formulas (see the HPLC chromatogram in Specifications).
Stable resveratrol supply is backed by the group's sourcing system, and the powder is available for sale worldwide from 1 kg.
Natural vs Water-Soluble vs Synthetic Resveratrol
Dimension | Natural Resveratrol 98% (PMB0501) | Water-Soluble Resveratrol 10% (PMB0502) | Synthetic resveratrol |
Source | Polygonum cuspidatum root, natural extraction | Natural resveratrol on water-soluble carrier | Chemical synthesis |
Assay | ≥98% (HPLC) | ≥10.00% | Typically ≥99% |
Colour | White to off-white | White fine powder | — |
Typical use | Concentrated actives, serums, emulsions | Clear water-based formulas, toners, essences | Cost-driven supply |
Documentation | 10-file set incl. TDS/COA/MSDS/MOA/NMPA dossier | TDS/COA/Composition Statement on file | — |
If a brief asks simply for "resveratrol", the 98% natural powder is the standard route; the 10% water-soluble grade solves dosing in clear water phases where the pure powder is hard to dissolve.
Resveratrol Specifications
98% Natural Resveratrol（PMB0501）
The 98% resveratrol powder form (PMB0501) is released lot by lot against the specification below.
Items | Specification |
Assay | ≥98% (HPLC) |
Appearance | Powder |
Color | White or off-white |
Odor | Characteristic |
Moisture | ≤0.5% |
Total heavy metals | ≤10 ppm |
Pb | ≤2 ppm |
As | ≤2 ppm |
Hg | ≤0.1 ppm |
Cd | ≤1 ppm |
Total plate count | ≤1000 cfu/g |
Yeast & mold count | ≤100 cfu/g |
Escherichia coli | Not detected |
Salmonella | Not detected |
99% Resveratrol
Items | Specification |
Botanical Source | Polygonum cuspidatum |
Assay | Resveratrol ≥99% |
Appearance | White fine powder |
Odor | Characteristic |
Taste | Characteristic |
Part used | Root |
Extraction solvent | Ethanol |
Particle size | 98% through 80 mesh |
Moisture | ≤1.0% |
Ash content | ≤0.5% |
Total heavy metals | ≤10 ppm |
As | ≤2 ppm |
Pb | ≤3 ppm |
Hg | ≤0.1 ppm |
Cd | ≤1 ppm |
Total plate count | ≤1000 cfu/g |
Total yeast & mold | ≤100 cfu/g |
E. coli | Negative |
Salmonella | Negative |
Staphylococcus | Negative |
10% Water-Soluble Resveratrol（PMB0502）
Items | Specification |
Assay | ≥10.00% |
Color | White fine powder |
Odor | Characteristic |
Taste | Characteristic |
Extract Solvent | Ethyl acetate / ethanol & water |
Particle Size | 98% through 80 mesh |
Moisture | ≤5.0% |
Ash content | ≤5.0% |
Heavy metals | ≤10 ppm |
Arsenic | ≤2 ppm |
Plumbum | ≤3 ppm |
Mercury | ≤0.1 ppm |
Cadmium | ≤1 ppm |
Total Plate count | ≤1000 cfu/g |
Yeast & mold | ≤100 cfu/g |
Escherichia coli | Negative |
Staphylococcus | Negative |
Salmonella | Negative |
Three rows matter most for formulators. Assay (≥98%) defines the concentrated grade for low-inclusion dosing. Moisture (≤0.5%) protects a polyphenol that degrades under humidity and alkaline conditions. Colour (white to off-white) is the visual outcome of the decoloring-plus-crystallization route — the whiter-powder edge behind the Characteristic positioning.
Resveratrol Benefits for Skin: Antioxidant, Anti-Aging and Whitening Support
Antioxidant protection. The resveratrol antioxidant profile starts from the core resveratrol mechanism of action: free-radical management: as a polyphenol it eliminates and inhibits the production of free radicals and resists lipid per-oxidation, and in-vitro studies place its antioxidant effect above vitamin C and vitamin E at comparable test conditions. It also regulates the activity of antioxidant-related enzymes. For skincare this supports antioxidant day-care and anti-pollution formulas.
Anti-aging support. In an animal study on skin aging, resveratrol scavenged free radicals, reduced H2O2 content in skin tissue and increased ATP-enzyme activity — countering skin aging driven by lipid peroxidation from free radicals and their metabolites, and helping maintain skin elasticity and thickness. To a certain degree, this supports anti-aging day-care and care for crepey skin: the extract is best positioned as a supporting active in crepey-skin repair treatment with resveratrol formulas rather than a stand-alone treatment.
Whitening and brightening support. Resveratrol can inhibit cell proliferation, significantly inhibits tyrosinase activity, and reduces melanin content — in B16 melanocyte tests the inhibition rate reached 53.17% at 0.02%, higher than arbutin and vitamin C at the tested concentrations (see Efficacy Tests). It also shows strong UV absorbency with a maximum at 366 nm, reducing radiation damage from ultraviolet light. Resveratrol for skin whitening therefore rests on in-vitro evidence: to a certain degree, the extract has the potential to support skin whitening and resveratrol skin whitening positioning — supporting skin lightening and brightening-even-tone formulas targeting the look of dark spots.
Skin comfort (in-vitro studies). Resveratrol inhibits the production of TxB2, a metabolite of arachidonic acid, and in-vitro studies show inhibition of NF-κB cell activity and activation of PPAR — mechanistic evidence behind soothing-positioning formulas. Separate in-vitro studies report inhibitory effects on Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus; these are laboratory results, not product claims.
Resveratrol In-Vitro Study Data
Test Item | Concentration | Result |
Elimination of free radical DPPH | EC50 | (39.5±2.8) μg/mL |
Inhibition of B-16 melanocytes | 0.02% | Inhibition rate: 53.17% |
Inhibition of tyrosinase activity | IC50 | 2.0 μg/mL |
Promotion of collagen production (cell culture) | 1.25 μmol/L | Promotion rate: 121 (blank 100) |
Promotion of fibroblasts proliferation (cell culture) | 5 μmol/L | Promotion rate: 141 (blank 100) |
Promotion of epidermal keratinocytes proliferation (cell culture) | 10 μmol/L | Promotion rate: 126 (blank 100) |
Determination of SPF (sun protection effect) | 1.5% | SPF value: 30 (blank 7) — in-vitro determination |
Inhibition of lipoxygenase-1 activity | IC50 | 1.02 μg/mL |
Inhibition of NF-κB cell activity | 5 μmol/L | Inhibition rate: 33.9% |
Activation promotion of Peroxisome Proliferator Activated Receptor (PPAR) | 50 μmol/L | Promotion rate: 139 (blank 100) |
Resveratrol Application in Skin Care Products
Resveratrol in skin care is widely used in anti-aging, antioxidant, brightening, sun-care-support and soothing lines. Resveratrol uses for skin span serum, emulsion, cream and toner formats: dosing resveratrol for skin care in oil-emulsion phases takes the 98% powder, while dosing resveratrol powder for skin in clear water phases uses the 10% water-soluble grade. Among the best resveratrol skin products concepts, skin functional resveratrol positioning means resveratrol benefits skin care formulas by pairing with vitamins and antioxidants — resveratrol benefits in skin care and the resveratrol skin care benefits documented in vitro justify typical inclusions of 0.5–2%. Typical use levels follow the reference formula below.
Formulation notes:
Resveratrol is often used in combination with vitamins such as vitamin C, vitamin E and vitamin A derivatives.
Resveratrol is unstable under alkaline conditions (pH > 10) and will turn pink or red.
Resveratrol can be used in combination with AHA to reduce the irritation of AHA on skin.
Reference Formula: Anti-Wrinkle Emulsion
Ingredient | Content (%) | Ingredient | Content (%) |
Resveratrol | 2.0 | Triethanolamine | 0.15 |
Glycolic acid | 8.0 | 1,3-butanediol | 3.0 |
Mineral oil | 4.0 | Xanthan gum | 0.3 |
1,3-Dimethyl-2-imidazolidinone | 1.0 | Fragrance | Appropriate |
Cetyl alcohol polyoxyethylene (10) ether | 4.0 | Butylparaben | 0.01 |
Cetanol | 4.0 | Refined water | Add to 100 |
Resveratrol Safety & Storage
Regulatory status. Resveratrol (CAS 501-36-0) is a globally known cosmetic antioxidant active; regulatory statements (Allergen, Animal-Free, GMO Statement, Country of Origin) are on file and can be sent with the documentation set. The NMPA raw-material safety dossier (Attachment 14 / submission code) is also on file for China registration support.
Packing and Storage.
Package: 1–10 kg aluminium-foil bags; 10–25 kg fibre drums with double plastic bags inside.
Storage: stored in a cool, dry place away from direct sunlight and oxidizing agents.
Resveratrol Documentation & Ordering
Plamed is a natural resveratrol manufacturer and resveratrol supplier based in China, offering resveratrol powder in 98%, 99% and 10% water-soluble grades from 1 kg. For resveratrol wholesale, resveratrol powder wholesale and wholesale resveratrol powder cooperation — including buy resveratrol powder wholesale requests and china powdered resveratrol wholesale supply — contact Plamed for the quote, samples and the full documentation set. Whether you are comparing resveratrol powder manufacturers, china resveratrol manufacturers, china resveratrol powder manufacturers, pure resveratrol powder manufacturers or resveratrol powder suppliers, or simply want to buy resveratrol and buy resveratrol powder for a new formula, the sample and COA of the matching grade ship with your inquiry.
Available Document of Resveratrol
Technical Data Sheet (TDS - Natural 98% )
Technical Data Sheet (TDS - Synthetic 99% )
Technical Data Sheet (TDS - Water-Soluble 10% )
Certificate of Analysis (COA - 98%, 99%, 10% Water-Soluble Grades)
Material Safety Data Sheet (MSDS)
Composition Statement / Compositional Breakdown (Natural 98% & Water-Soluble 10%)
Manufacturing Process Flowchart
Method of Analysis (MOA / HPLC Test Method & Chromatograms)
Regulatory Statements (Allergen, Animal-Free, GMO Statement, Country of Origin)
NMPA Raw Material Safety Dossier (Attachment 14 / Submission Code)
Product Brochure & Technical Introduction
For samples, lead time and the full document set, contact Plamed Green Science Group here.
Resveratrol: Frequently Asked Questions
Q1. What are the natural sources of resveratrol?
Natural sources of resveratrol include hellebore, Polygonum cuspidatum, grape, peanut and pineapple. Plamed resveratrol is extracted from the root of Polygonum cuspidatum (Japanese knotweed), a natural cosmetic raw material — no synthetic resveratrol is added.
Q2. What is the structure of resveratrol?
The structure of resveratrol is a trans-stilbene skeleton: two phenolic rings joined by an ethylene bridge with three hydroxyl groups (3,5,4′-trihydroxystilbene, C14H12O3, 228.24 g/mol, CAS 501-36-0).
Q3. What is the resveratrol mechanism of action?
The main resveratrol mechanism of action is free-radical management: it eliminates and inhibits free-radical production, resists lipid per-oxidation and regulates antioxidant-enzyme activity. In-vitro studies also show tyrosinase inhibition (IC50 2.0 μg/mL), NF-κB inhibition and PPAR activation.
Q4. What are the resveratrol skin benefits?
The benefits of resveratrol for skin centre on antioxidant protection, anti-aging support and brightening-even-tone support. Documented resveratrol effects on skin include free-radical scavenging, reduced H2O2 content and higher ATP-enzyme activity in skin tissue, plus tyrosinase and B16-melanocyte inhibition in vitro; resveratrol on skin cells further shows collagen-related promotion in culture. This is why resveratrol skin care products — from a resveratrol serum for skin brightening step to day creams — build on resveratrol for skin benefits such as care for visible skin aging. In short, resveratrol for the skin is an antioxidant-support active for anti-aging, brightening and soothing lines. See the Benefits and Efficacy Tests tabs for the underlying data.
Q5. What is water-soluble resveratrol?
Water soluble resveratrol (PMB0502) is a 10% grade that dissolves clearly in water phases, solving the dosing limits of the lipophilic pure powder (log Pow 2.8). It is designed for clear toners, essences and water-based serums.
Q6. Can resveratrol be used for skin whitening?
Resveratrol for skin lightening and skin whitening rests on in-vitro data: in B16 melanocyte and tyrosinase tests, resveratrol showed 53.17% inhibition of melanin content at 0.02% and an IC50 of 2.0 μg/mL on tyrosinase activity. These results suggest that, to a certain degree, it has the potential to support whitening goals in brightening formulas.
Q7. Is resveratrol suitable for crepey skin repair treatment?
Resveratrol skin aging evidence comes from animal studies: reduced H2O2 content and increased ATP-enzyme activity in skin tissue, countering free-radical-driven peroxidation. This supports its use as a supporting active in crepey skin repair treatment with resveratrol formulas — best combined with vitamins and used at the reference dosage; it is not a stand-alone medical treatment.
Q8. Where to buy resveratrol?
If you are looking for where to buy pure resveratrol, you can buy resveratrol and buy resveratrol powder directly from Plamed: MOQ 1 kg, with 98%, 99% and 10% water-soluble grades available. Send an inquiry for resveratrol for sale, wholesale cooperation and the matching COA/TDS.
Q9. How is resveratrol spelled — what about resverol, revesterol, resverotrol or resvertarol?
The correct spelling is resveratrol. Common misspellings include resverol, revesterol, resverotrol and resvertarol — all refer to the same natural polyphenol (CAS 501-36-0) described on this page.
Q10. What is the resveratrol powder form and packaging?
The powder form is a white to off-white fine powder (98% through 80 mesh on the 99%/10% grades), packed in 1–10 kg aluminium-foil bags and 10–25 kg fibre drums, stored cool and dry away from sunlight and oxidizing agents.