Name: Magnolol
Brand: Plamed Green Science
SKU: –

Overview

Magnolol is a polyphenol compound. It exists with its isomers Honokiol in dry root of the Chinese herb magnolia officinalis. They are mainly found in magnolia plant, with a content of about 5%. It has anti-inflammatory and anti-ulcer properties. So it can be used to prevent skin problems such as acne and pimple. At the same time, Magnolol has significant antibacterial effect; it can improve cellular immunity. Thus it can be used for anti-caries in oral hygiene products, also inhibiting tooth decay. Magnolol can also be used as a preservative in cosmetics. As a skin whitening agent, Magnolol can capture free radicals and inhibit tyrosinase activity. It has a broad application prospect in anti-acne and anti-inflammation, skin whitening cosmetics, personal care and oral health products.

Product Name	CAS Number	INCI Name
Magnolol	528-43-8	MAGNOLOL
Molecular Formula	Molecular Weight	Molecular Structure
C18H18O2	266.32g/mol
Product ID	Specificcation	Minimal Package	Minimal Order Quantity
PMQD0202	98%	1KG	1KG

Source

Magnolia officinalis (Latin name: Magnolia officinalis Rehd. Et Wils.) is a deciduous plant of genus Magnolia of Magnoliaceae. The content of Magnolol in magnolia’s different parts varies greatly; the total content of Magnolol in magnolia leaves is 2.30%, while the total content in root of magnolia is 8.22%. However, magnolia grows slowly and has a long growth cycle. It generally takes 10 to 15 years. In addition, magnolia is now listed as a national secondary wild protection plant. Therefore, extracting Magnolol from plant magnolia has a considerable destruction to natural resources. Nowadays, synthesis method is efficient and can protect magnolia resources.

	Plant extraction	Chemical synthesis
History	In 1930s, a Japanese scholar first isolated Magnolol from magnolia officinalis.	It is first synthesized by Swedish scientists H.Erdtman and J.Runebeng through the coupling reaction using 4-allylphenol as raw material.
Advantage	Natural source; high purity.	The reaction treatment is simple and efficient; low cost; magnolia resources protection.
Disadvantage	Serious damage to natural resources.	Too much residual organic solvents; discharge of chemical waste liquid; serious chemical pollution.
Improved method	Magnolia leaf also contains Magnolol, but the content is low, only 0.29-0.36%. However, magnolia leaves are abundant, and the fallen leaves are of equal quality with magnolia bark every autumn. Therefore, extracting Magnolol from leaves not only protects magnolia resources, but also is economical.	Endogenous fungi fermentation to produce Magnolol.

Manufacturer Specifications

Product Name	Specification
Magnolol	98% HPLC

Items	Specification
Assay	≥98.00%
Color	White fine powder
Odor	Characteristic
Taste	Characteristic
Extract Solvent	Water & ethanol
Part used	Bark
Physical Characteristics
Particle Size		98% through 80 mesh
Moisture		≤1.00%
Ash content		≤1.00%
Bulk density		50-60g/100ml
Solvent Residue		Eur. Pharm
Heavy Metals
Heavy metals		≤10ppm
Arsenic		≤2ppm
Plumbum		≤2ppm
Microbiological Tests
Total Plate count		≤1000cfu/g
Yeast & mold		≤100cfu/g
Escherichia coli		Negative
Staphylococcus		Negative
Salmonella		Negative

Manufacturer Flow Chart

Benefits

Acne treatment and anti-inflammation

Inhibition test result of propionibacterium acnes shows that Magnolol has a stronger inhibitory effect on propionibacterium acnes than metronidazole. Magnolol can inhibit production of inflammatory enzymes, and suppress activation of NF-κB and MAPKs. It exhibits anti-inflammation property. Studies have found that Magnolol can significantly affect function of leukocyte; and it has a strong inhibitory effect on the biosynthesis of inflammatory mediators LTB4 and 5-HETE. Because of its anti-inflammatory activity, Magnolol can be used in acne treatment products to prevent skin inflammation.

Anti-bacterial

Study indicates that Magnolol can significantly inhibit the growth and production of cariogenic bacteria including streptococcus mutans, streptococcus sanguis, lactobacillus; and its inhibition effect strengthens with the increase of concentration. So Magnolol can be used for periodontitis treatment in oral care products. In addition, Magnolol can also be used as a natural antiseptic in cosmetic cream. A domestic experiment is conducted to add Magnolol as a preservative to facial cream; and appearance, aroma and pH of the cream are normal, which indicates that Magnolol has good compatibility.

Whitening

It has been proved by some scholars that inhibitory rate of 0.01% Magnolol on tyrosinase is 64.2%. Magnolol is a whitening agent that can capture free radicals and inhibit tyrosinase activity. Using L-tyrosine or L-dopa as substrate and kolic acid as positive control, it is found that Magnolol has good effect of inhibiting tyrosinase. It proves that Magnolol has certain whitening effect and can be added into cosmetics as skin whitening agent.

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Pharmacological Studies

Test Item	Concentration	Result
Elimination of hydroxyl radicals	0.2mmol/L	Elimination rate: 81.2%
Inhibition of unsaturated fatty acid peroxidation	0.2mmol/L	Elimination rate: 87.8%
Inhibition of tyrosinase activity	0.01%	Inhibition rate: 64.2%
Activation of peroxidase PPAR	100μmol/L	Promotion rate: 206（blank 100）
Inhibition of NF-kB cell activity	20μmol/L	Inhibition rate: 61.3%
Inhibition of IL-1 production induced by LPS	3.123mg/mL	Inhibition rate: 54.9%
Inhibition of IL-6 production induced by LPS	3.123mg/mL	Inhibition rate: 56.3%

Application

Magnolol, due to its anti-bacterial property, can be used as cosmetics preservative, and can be added into toothpaste and mouth wash for treatment of periodontitis (the recommended dosage in dental product is 0.4%).
Magnolol, because of its anti-inflammatory activity, can be applied in cream, emulsion, essence and mask to prevent pimple, acne.
As a skin-whitening agent, Magnolol also can used in whitening mask, cream and cleanser.

Magnolol application cases in major cosmetic brands in the world:

Country	Brand	Product
China	MULANTE	Peptide Luxury Protection Cream
	Skin Designer	Hydrating Silk Mask
	DR.WU	Pore Clarifying Toner with BHA
	EEASSU	Active Peptide Enriched Toner
Switzerland	L’ADMIRER	(Beauty Plus Defensil Concentrate
USA	NARS	Soft Matte
USA	ORIGINS	Refreshing Eye Cream
France	MedSPA	MedSPA Botox-Like Swiss Syn-Ake Lifting Serum
France	Isabelle Lancray	Isabelle Lancray Gommage Visage Doux-Gel Exfoliant Moussant
Korea	ASF	ASF ANTI-SEBUM After Skin AC Lotion
German	Eucerin	Volume-Filler Day Care Dry Skin
Japan	IMPRESS	White Cream Returnergy White Returnergy A
Japan	KANEBO	Blanchir Superior Whitening W Conclusion E

Reference Formula

Bath soap

Ingredient	Content(%)	Ingredient	Content(%)
Magnolol	0.8	Lauric acid	2.5
KOH	3.6	Myristic acid	7.5
Fragrance	0.6	Pigment	0.001
Oleic acid	2.5	Lauryl diethanolamide	5
Glycerin	20	Palmitic acid	2.5
Aqua	Add to 100

Lotion for external use

Ingredient	Content(%)	Ingredient	Content(%)
Magnolol	1.0	Ethanol	10.0
1,3-Butanediol	4.0	Water	Add to 100

Whitening toner

Ingredient	Content(%)	Ingredient	Content(%)
Magnolol	1.0	Ethanol	10.0
1,3-Butanediol	10.0	Water	Add to 100

Safety & Storage

Magnolol Safety

Cosmetic, Toiletry &Fragrance Association (CTFA) has specified Magnolol as a cosmetics ingredient.
Magnolol is listed on The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014. No reports show its insecurity.

Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

Magnolol